Hypoxic inactivation of glycogen synthase kinase-3β promotes gastric tumor growth and angiogenesis by facilitating hypoxia-inducible factor-1 signaling

Apmis ◽  
2016 ◽  
Vol 124 (9) ◽  
pp. 748-756 ◽  
Author(s):  
Young San Ko ◽  
Sung Jin Cho ◽  
Jinju Park ◽  
Yiseul Choi ◽  
Jae-Seon Lee ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Glycogen Synthase ◽  
Hypoxia Inducible Factor ◽  
Gastric Tumor ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3Β ◽  
Hypoxia Inducible Factor 1

scholarly journals mTORC1 Hyperactivity Inhibits Serum Deprivation-Induced Apoptosis via Increased Hexokinase II and GLUT1 Expression, Sustained Mcl-1 Expression, and Glycogen Synthase Kinase 3β Inhibition

2009 ◽  
Vol 29 (18) ◽  
pp. 5136-5147 ◽  
Author(s):  
Prashanth T. Bhaskar ◽  
Veronique Nogueira ◽  
Krushna C. Patra ◽  
Sang-Min Jeon ◽  
Youngkyu Park ◽  
...  
Keyword(s):  
Glycogen Synthase ◽  
Hypoxia Inducible Factor ◽  
Feedback Mechanism ◽  
Serum Deprivation ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3Β ◽  
Hexokinase Ii ◽  
Negative Feedback Mechanism ◽  
Glut1 Expression ◽  
Induced Apoptosis

ABSTRACT The current concept is that Tsc-deficient cells are sensitized to apoptosis due to the inhibition of Akt activity by the negative feedback mechanism induced by the hyperactive mTORC1. Unexpectedly, however, we found that Tsc1/2-deficient cells exhibit increased resistance to serum deprivation-induced apoptosis. mTORC1 hyperactivity contributes to the apoptotic resistance of serum-deprived Tsc1/2-deficient cells in part by increasing the growth factor-independent expression of hexokinase II (HKII) and GLUT1. mTORC1-mediated increase in hypoxia-inducible factor 1α (HIF1α) abundance, which occurs in the absence of serum in normoxic Tsc2-deficient cells, contributes to these changes. Increased HIF1α abundance in these cells is attributed to both an increased level and the sustained translation of HIF1α mRNA. Sustained glycogen synthase kinase 3β inhibition and Mcl-1 expression also contribute to the apoptotic resistance of Tsc2-deficient cells to serum deprivation. The inhibition of mTORC1 activity by either rapamycin or Raptor knockdown cannot resensitize these cells to serum deprivation-induced apoptosis because of elevated Akt activity that is an indirect consequence of mTORC1 inhibition. However, the increased HIF1α abundance and the maintenance of Mcl-1 protein expression in serum-deprived Tsc2 −/ − cells are dependent largely on the hyperactive eIF4E in these cells. Consistently, the reduction of eIF4E levels abrogates the resistance of Tsc2 −/ − cells to serum deprivation-induced apoptosis.

β-Thujaplicin inhibits basal-like mammary tumor growth by regulating glycogen synthase kinase-3β/β-catenin signaling

2019 ◽  
Vol 10 (5) ◽  
pp. 2691-2700 ◽  
Author(s):  
Jing Chen ◽  
Jiwon Ko ◽  
Jin Tae Kim ◽  
Jae Seok Cho ◽  
Shuai Qiu ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Chronic Diseases ◽  
Mammary Tumor ◽  
Glycogen Synthase ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3Β ◽  
Mammary Tumor Growth

β-Thujaplicin, a natural monoterpenoid, has been demonstrated to exert health beneficial activities in chronic diseases.

scholarly journals Glycogen synthase kinase 3β inhibitors induce apoptosis in ovarian cancer cells and inhibit in-vivo tumor growth

2011 ◽  
pp. 1 ◽  
Author(s):  
Tyvette S. Hilliard ◽  
Irina N. Gaisina ◽  
Amanda G. Muehlbauer ◽  
Arsen M. Gaisin ◽  
Franck Gallier ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Tumor Growth ◽  
Cancer Cells ◽  
Glycogen Synthase ◽  
Glycogen Synthase Kinase ◽  
Ovarian Cancer Cells ◽  
Glycogen Synthase Kinase 3Β

Abstract LB-290: Glycogen synthase kinase-3β inhibits tumor growth and angiogenesis of gastric cancer

2011 ◽  
Author(s):  
Young San Ko ◽  
Sung Jin Cho ◽  
Jiyeon Yoon ◽  
Mee Soo Chang ◽  
Byung Lan Lee
Keyword(s):  
Gastric Cancer ◽  
Tumor Growth ◽  
Glycogen Synthase ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3Β

Is Going for Cure in CML Targeting Aberrant Glycogen Synthase Kinase 3β?

2017 ◽  
Vol 18 (4) ◽  
pp. 396-404
Author(s):  
Concetta Saponaro ◽  
Michele Maffia ◽  
Nicola Renzo ◽  
Addolorata Coluccia
Keyword(s):  
Glycogen Synthase ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3Β

scholarly journals Contrasting Effects of Inhibitors Li+ and Be2+ on Catalytic Cycle of Glycogen Synthase Kinase-3β

2021 ◽  
Author(s):  
David J. Reilley ◽  
Zaher Arraf ◽  
Anastassia N. Alexandrova
Keyword(s):  
Glycogen Synthase ◽  
Catalytic Cycle ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3Β
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