Curcumin Ameliorates Kidney Function and Oxidative Stress in Experimental Chronic Kidney Disease

Background: Autoclaving rodent diets is common in laboratory animals, but autoclaving increases the formation of dietary advanced glycation end-products (AGE). We studied the effect of autoclaved (AC) diet alone or in combination with a diet high in bioavailable phosphorus on biochemistries of chronic kidney disease-mineral and bone disorder (CKD-MBD), intestinal gene expression, and oxidative stress. Methods: Male CKD rats (Cy/+) and normal littermates were fed 1 of 3 diets: AC 0.7% phosphorus grain-based diet for 28 weeks (AC); AC diet for 17 weeks followed by non-autoclaved (Non-AC) 0.7% phosphorus casein diet until 28 weeks (AC + Casein); or Non-AC diet for 16 weeks followed by a Non-AC purified diet until 30 weeks (Non-AC + Casein). Results: AC diets contained ~3× higher AGEs and levels varied depending on the location within the autoclave. Rats fed the AC and AC + Casein diets had higher total AGEs and oxidative stress, irrespective of kidney function. Kidney function was more severely compromised in CKD rats fed AC or AC + Casein compared to Non-AC + Casein. There was a disease-by-diet interaction for plasma phosphorus, parathyroid hormone, and c-terminal fibroblast growth factor-23, driven by high values in the CKD rats fed the AC + Casein diet. Compared to Non-AC + Casein, AC and AC + Casein-fed groups had increased expression of receptor of AGEs and intestinal NADPH oxidase dual oxidase-2, independent of kidney function. Conclusions: Autoclaving rodent diets impacts the progression of CKD and CKD-MBD, highlighting the critical importance of standardizing diets in experiments.

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Association of Sarcopenia and Gut Microbiota Composition in Older Patients with Advanced Chronic Kidney Disease, Investigation of the Interactions with Uremic Toxins, Inflammation and Oxidative Stress

Toxins ◽

10.3390/toxins13070472 ◽

2021 ◽

Vol 13 (7) ◽

pp. 472

Author(s):

Elisabetta Margiotta ◽

Lara Caldiroli ◽

Maria Luisa Callegari ◽

Francesco Miragoli ◽

Francesca Zanoni ◽

...

Keyword(s):

Oxidative Stress ◽

Chronic Kidney Disease ◽

Kidney Disease ◽

Gut Microbiota ◽

Inflammatory Cytokines ◽

Interleukin 10 ◽

Uremic Toxins ◽

Interleukin 12 ◽

European Working ◽

And Oxidative Stress

Background: Sarcopenia is a prevalent condition in chronic kidney disease (CKD). We determined gut microbiota (gMB) composition in CKD patients with or without sarcopenia. Furthermore, we investigated whether in these patients, there was any association between gMB, uremic toxins, inflammation and oxidative stress. Methods: We analyzed gMB composition, uremic toxins (indoxyl sulphate and p-cresyl sulphate), inflammatory cytokines (interleukin 10, tumor necrosis factor α, interleukin 6, interleukin 17, interleukin 12 p70, monocyte chemoattractant protein-1 and fetuin-A) and oxidative stress (malondialdehyde) of 64 elderly CKD patients (10 < eGFR < 45 mL/min/1.73 m2, not on dialysis) categorized as sarcopenic and not-sarcopenic. Sarcopenia was defined according to European Working Group on Sarcopenia in Older People 2 criteria. Results: Sarcopenic patients had a greater abundance of the Micrococcaceae and Verrucomicrobiaceae families and of Megasphaera, Rothia, Veillonella, Akkermansia and Coprobacillus genera. They had a lower abundance of the Gemellaceae and Veillonellaceae families and of Acidaminococcus and Gemella genera. GMB was associated with uremic toxins, inflammatory cytokines and MDA. However, uremic toxins, inflammatory cytokines and MDA were not different in sarcopenic compared with not-sarcopenic individuals, except for interleukin 10, which was higher in not-sarcopenic patients. Conclusions: In older CKD patients, gMB was different in sarcopenic than in not-sarcopenic ones. Several bacterial families and genera were associated with uremic toxins and inflammatory cytokines, although none of these latter substantially different in sarcopenic versus not-sarcopenic patients.

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Skeletal Muscle Regeneration and Oxidative Stress Are Altered in Chronic Kidney Disease

PLoS ONE ◽

10.1371/journal.pone.0159411 ◽

2016 ◽

Vol 11 (8) ◽

pp. e0159411 ◽

Cited By ~ 23

Author(s):

Keith G. Avin ◽

Neal X. Chen ◽

Jason M. Organ ◽

Chad Zarse ◽

Kalisha O’Neill ◽

...

Keyword(s):

Oxidative Stress ◽

Skeletal Muscle ◽

Chronic Kidney Disease ◽

Kidney Disease ◽

Muscle Regeneration ◽

Skeletal Muscle Regeneration ◽

And Oxidative Stress

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SP436EFFECT OF LEVOCARNITINE ON LIPID METABOLISM AND OXIDATIVE STRESS IN PATIENTS WITH CHRONIC KIDNEY DISEASE

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfv193.44 ◽

2015 ◽

Vol 30 (suppl_3) ◽

pp. iii522-iii522

Author(s):

Mariana Koziy ◽

Liliya Martynyuk

Keyword(s):

Oxidative Stress ◽

Chronic Kidney Disease ◽

Lipid Metabolism ◽

Kidney Disease ◽

And Oxidative Stress

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Alteration and association between serum ACE2/ angiotensin(1-7)/Mas axis and oxidative stress in chronic kidney disease

Medicine ◽

10.1097/md.0000000000021492 ◽

2020 ◽

Vol 99 (31) ◽

pp. e21492 ◽

Cited By ~ 1

Author(s):

Chengqian Shi ◽

Keda Lu ◽

Hong Xia ◽

Peipei Zhang ◽

Bingbing Zhang

Keyword(s):

Oxidative Stress ◽

Chronic Kidney Disease ◽

Kidney Disease ◽

And Oxidative Stress

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Misdistribution of iron and oxidative stress in chronic kidney disease

Free Radical Biology and Medicine ◽

10.1016/j.freeradbiomed.2018.06.025 ◽

2019 ◽

Vol 133 ◽

pp. 248-253 ◽

Cited By ~ 20

Author(s):

Takeshi Nakanishi ◽

Takahiro Kuragano ◽

Masayoshi Nanami ◽

Yasuyuki Nagasawa ◽

Yukiko Hasuike

Keyword(s):

Oxidative Stress ◽

Chronic Kidney Disease ◽

Kidney Disease ◽

And Oxidative Stress

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The Axis AGE-RAGE-Soluble RAGE and Oxidative Stress in Chronic Kidney Disease

Advances in Experimental Medicine and Biology - Oxidative Stress and Inflammation in Non-communicable Diseases - Molecular Mechanisms and Perspectives in Therapeutics ◽

10.1007/978-3-319-07320-0_14 ◽

2014 ◽

pp. 191-208 ◽

Cited By ~ 25

Author(s):

Alejandro Gugliucci ◽

Teresita Menini

Keyword(s):

Oxidative Stress ◽

Chronic Kidney Disease ◽

Kidney Disease ◽

Soluble Rage ◽

And Oxidative Stress

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Dietary Antioxidant Supplements and Uric Acid in Chronic Kidney Disease: A Review

Nutrients ◽

10.3390/nu11081911 ◽

2019 ◽

Vol 11 (8) ◽

pp. 1911 ◽

Cited By ~ 18

Author(s):

Stefanos Roumeliotis ◽

Athanasios Roumeliotis ◽

Evangelia Dounousi ◽

Theodoros Eleftheriadis ◽

Vassilios Liakopoulos

Keyword(s):

Oxidative Stress ◽

Chronic Kidney Disease ◽

Uric Acid ◽

Kidney Disease ◽

Serum Levels ◽

Maintenance Hemodialysis ◽

Antioxidant Supplements ◽

Stage Renal Disease ◽

End Stage ◽

And Oxidative Stress

Increased serum levels of uric acid have been associated with the onset and development of chronic kidney disease (CKD), cardiovascular disease, and mortality, through several molecular pathogenetic mechanisms, such as inflammation and oxidative stress. Oxidative stress is present even in the early stages of CKD, progresses parallelly with the deterioration of kidney function, and is even more exacerbated in end-stage renal disease patients undergoing maintenance hemodialysis. Although acting in the plasma as an antioxidant, once uric acid enters the intracellular environment; it behaves as a powerful pro-oxidant. Exogenous intake of antioxidants has been repeatedly shown to prevent inflammation, atherosclerosis and oxidative stress in CKD patients. Moreover, certain antioxidants have been proposed to exert uric acid-lowering properties. This review aims to present the available data regarding the effects of antioxidant supplements on both oxidative stress and uric acid serum levels, in a population particularly susceptible to oxidative damage such as CKD patients.

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