scholarly journals Lack of negative impact of Philadelphia chromosome in older patients with acute lymphoblastic leukaemia in the thyrosine kinase inhibitor era: comparison of two prospective parallel protocols

2012 ◽  
Vol 159 (4) ◽  
pp. 485-488 ◽  
Author(s):  
Josep-María Ribera ◽  
Olga García ◽  
Pascual Fernández-Abellán ◽  
Esperanza Lavilla ◽  
María-Teresa Bernal ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Older Patients ◽  
Kinase Inhibitor ◽  
Negative Impact ◽  
Philadelphia Chromosome

Emerging BCR/ABL1 Mutations Under Treatment with Tyrosine Kinase Inhibitors in Paediatric Acute Lymphoblastic Leukaemia

2015 ◽  
Vol 134 (2) ◽  
pp. 71-75 ◽  
Author(s):  
Agueda Molinos-Quintana ◽  
Virginia Aquino ◽  
Isabel Montero ◽  
Concepción Pérez-de Soto ◽  
Raúl García-Lozano ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Kinase Inhibitors ◽  
Kinase Inhibitor ◽  
Clonal Selection ◽  
Philadelphia Chromosome ◽  
Kinase Domain ◽  
Mutational Status ◽  
Tyrosine Kinase Inhibitor Therapy

We report on the emergence and clinical relevance of an unusual BCR-ABL1 kinase domain mutational status in a 2-year-old female with p210-BCR-ABL Philadelphia chromosome-positive acute lymphoblastic leukaemia. We detected three BCR-ABL1 clones determined by the presence of the E255V, D276G and F317L mutations. We point out the usefulness of searching for mutated populations that survive tyrosine-kinase inhibitor therapy and the role of their clonal selection over time in relation to therapeutic intervention.

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