scholarly journals Susceptibility to 6-MP toxicity conferred by aNUDT15variant in Japanese children with acute lymphoblastic leukaemia

2015 ◽  
Vol 171 (1) ◽  
pp. 109-115 ◽  
Author(s):  
Yoichi Tanaka ◽  
Motohiro Kato ◽  
Daisuke Hasegawa ◽  
Kevin Y. Urayama ◽  
Hisaya Nakadate ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Japanese Children

Genetic polymorphisms of thiopurine S-methyltransferase and 6-mercaptopurine toxicity in Japanese children with acute lymphoblastic leukaemia

2001 ◽  
Vol 11 (3) ◽  
pp. 269-273 ◽  
Author(s):  
Maki Ando ◽  
Yuichi Ando ◽  
Yoshinori Hasegawa ◽  
Yoshitaka Sekido ◽  
Kaoru Shimokata ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukaemia ◽  
Genetic Polymorphisms ◽  
Lymphoblastic Leukaemia ◽  
Japanese Children

Screening for the P2RY8-CRLF2 fusion gene in childhood acute lymphoblastic leukaemia

2011 ◽  
Vol 223 (03) ◽  
Author(s):  
M Morak ◽  
R Joas ◽  
S Fischer ◽  
A Attarbaschi ◽  
G Mann ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Fusion Gene ◽  
Childhood Acute Lymphoblastic Leukaemia

Cerebral sinovenous thrombosis during asparaginase treatment

2003 ◽  
Vol 23 (03) ◽  
pp. 109-112
Author(s):  
A. Hirt ◽  
C. Zwicky ◽  
W.A. Wuillemin ◽  
K. Leibundgut
Keyword(s):  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Induction Treatment ◽  
Pathogenic Mechanisms ◽  
Cerebral Sinovenous Thrombosis ◽  
Haemorrhagic Infarction ◽  
Sinovenous Thrombosis

SummaryA boy (age: 71/12 years) with acute lymphoblastic leukaemia developed thrombosis of the sinus sagitalis superior with secondary haemorrhagic infarction while on induction treatment with vincristine, prednisone, and asparaginase. Based on this report, the potential pathogenic mechanisms are discussed with respect to congenital prothrombotic defects as well as to the role of antileukaemic treatment. Current hypotheses on mechanisms for thromboembolism in children and proposed prophylactic strategies are briefly summarized.

Sign in / Sign up

Export Citation Format

Share Document