scholarly journals Chronic nicotine improves short-term memory selectively in a G72 mouse model of schizophrenia

2014 ◽  
Vol 171 (7) ◽  
pp. 1758-1771 ◽  
Author(s):  
B Hambsch ◽  
H Keyworth ◽  
J Lind ◽  
D M Otte ◽  
I Racz ◽  
...  
Keyword(s):  
Mouse Model ◽  
Short Term Memory ◽  
Short Term ◽  
Term Memory ◽  
Chronic Nicotine

scholarly journals Epigallocatechin-3-gallate improves cardiac hypertrophy and short-term memory deficits in a Williams-Beuren syndrome mouse model

PLoS ONE ◽  
2018 ◽  
Vol 13 (3) ◽  
pp. e0194476 ◽  
Author(s):  
Paula Ortiz-Romero ◽  
Cristina Borralleras ◽  
Mònica Bosch-Morató ◽  
Biuse Guivernau ◽  
Guillermo Albericio ◽  
...  
Keyword(s):  
Mouse Model ◽  
Cardiac Hypertrophy ◽  
Short Term Memory ◽  
Memory Deficits ◽  
Short Term ◽  
Term Memory

scholarly journals A β-secretase modulator decreases Tau pathology and preserves short-term memory in a mouse model of neurofibrillary degeneration

2021 ◽  
Author(s):  
Marie Tautou ◽  
Sabiha Eddarkaoui ◽  
Florian Descamps ◽  
Paul-Emmanuel Larchanche ◽  
Melanie Dumoulin ◽  
...  
Keyword(s):  
Nitrogen Atom ◽  
Mouse Model ◽  
Short Term Memory ◽  
Tau Pathology ◽  
Short Term ◽  
Term Memory ◽  
Transgenic Model ◽  
Structure Activity ◽  
Inflammatory Processes

A structure-activity relationship has enabled us to identify two molecules, MAGS02-14 and PEL24-199, sharing a β-secretase modulatory effect but having or not a lysosomotropic activity, respectively. More importantly, MAGS02-14 and PEL24-199 only differ from each other by a single nitrogen atom. However, which of the lysosomotropic and/or β-secretase modulating activities is necessary for the pharmacological effect in vivo remains ill-defined. To address this question, the THY-Tau22 transgenic model of NFD was treated for 6 weeks in a curative paradigm and short-term memory, Tau burden, and inflammatory processes were studied. PEL24-199, possessing only the β-secretase modulatory activity, was shown to restore the short-term memory and to reduce NFD. This effect was associated with reduced phosphorylation of Tau, increased phosphatase expression, and a decrease of astrogliosis. Our results, therefore, suggest that the lysosomotropic activity may be dispensable for the effect on both Aβ and Tau pathologies.

Mouse model for deficiency of methionine synthase reductase exhibits short-term memory impairment and disturbances in brain choline metabolism

2014 ◽  
Vol 461 (2) ◽  
pp. 205-212 ◽  
Author(s):  
Nafisa M. Jadavji ◽  
Renata H. Bahous ◽  
Liyuan Deng ◽  
Olga Malysheva ◽  
Marilyn Grand’maison ◽  
...  
Keyword(s):  
Mouse Model ◽  
Memory Impairment ◽  
Short Term Memory ◽  
Methionine Synthase ◽  
Dna Hypomethylation ◽  
Short Term ◽  
Term Memory ◽  
Methionine Synthase Reductase ◽  
Choline Metabolism ◽  
Mild Hyperhomocysteinaemia

Mice with mild hyperhomocysteinaemia due to methionine synthase reductase deficiency have impairments in short-term memory. DNA hypomethylation and compensatory disturbances in choline metabolism in the hippocampus lead to decreased levels of acetylcholine, a critical neurotransmitter in learning and memory.

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