scholarly journals Taspine is a natural product that suppresses P2X4 receptor activity via phosphoinositide 3‐kinase inhibition

2021 ◽  
Author(s):  
Izzuddin Bin Nadzirin ◽  
Anna Fortuny‐Gomez ◽  
Neville Ngum ◽  
David Richards ◽  
Seema Ali ◽  
...  
Keyword(s):  
Natural Product ◽  
Receptor Activity ◽  
Kinase Inhibition ◽  
P2x4 Receptor ◽  
Phosphoinositide 3 Kinase

scholarly journals A platelet biomarker for assessing phosphoinositide 3-kinase inhibition during cancer chemotherapy

2007 ◽  
Vol 6 (9) ◽  
pp. 2600-2607 ◽  
Author(s):  
Rita K. Bowers ◽  
Philip Marder ◽  
Lisa J. Green ◽  
Candice L. Horn ◽  
Andrew L. Faber ◽  
...  
Keyword(s):  
Cancer Chemotherapy ◽  
Kinase Inhibition ◽  
Phosphoinositide 3 Kinase

scholarly journals Pityriasis rubra pilaris-like erythroderma secondary to phosphoinositide 3-kinase inhibition

2018 ◽  
Vol 43 (8) ◽  
pp. 890-894 ◽  
Author(s):  
A. K. Dewan ◽  
L. Sowerby ◽  
S. Jadeja ◽  
C. Lian ◽  
P. Wen ◽  
...  
Keyword(s):  
Kinase Inhibition ◽  
Pityriasis Rubra Pilaris ◽  
Phosphoinositide 3 Kinase

Phosphoinositide-3-Kinase Inhibition Enhances Radiosensitization of Cervical Cancer In Vivo

2011 ◽  
Vol 21 (1) ◽  
pp. 100-105 ◽  
Author(s):  
Yi Liu ◽  
Baoxia Cui ◽  
Yunbo Qiao ◽  
Yan Zhang ◽  
Yongju Tian ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Cells ◽  
Kinase Inhibition ◽  
Clonogenic Assays ◽  
Akt Phosphorylation ◽  
Pi3k Activity ◽  
Pi3k Inhibition ◽  
Tumor Regrowth ◽  
Phosphoinositide 3 Kinase

Background:Phosphoinositide-3-kinase (PI3K)/Akt pathway is downregulated in several human cancers, and PI3K inhibition can sensitize these cancer cells to radiation. However, no research on cervical cancer in vivo has been reported. The present study further investigated whether PI3K inhibition could sensitize cervical cancer to radiation in vivo.Methods:HeLa cells with sustained PI3K activity and Akt phosphorylation were injected subcutaneously into BALB/C nude mice to establish tumor cell xenograft, which were randomly assigned to control, PI3K inhibitor LY294002 alone, radiation alone, or combined LY294002 and radiation group. Akt phosphorylation was detected by Western blotting to evaluate the blocking efficiency on PI3K activity. The radiosensitization of PI3K inhibition was measured by clonogenic assays, apoptosis analysis, and tumor regrowth assays.Results:The combination of LY294002 and radiation resulted in significant and synergistic suppression of cervical cancer cells in a dose-dependent manner in clonogenic assays (P< 0.05), higher ratio of apoptosis cells, and more remarkable reduction of Akt phosphorylation. Tumor regrowth delay curve showed the lowest increase of tumor volume in the combined group (37 days in average) (P= 0.003). Besides, LY294002 (100 mg/kg) alone decreased cell survival and produced xenograft regrowth delay.Conclusions:Phosphoinositide-3-kinase inhibition by LY294002 can synergistically enhance radiation efficacy via dephosphorylation of Akt in cervical cancer, and PI3K inhibition alone can also suppress tumor regrowth. This may provide novel therapeutic opportunities to enhance the effect of radiotherapy against cervical cancer.

Phosphoinositide-3-kinase inhibition with theophylline reverses steroid insensitivity in acute alcoholic hepatitis

2011 ◽  
Vol 77 (1) ◽  
pp. 157 ◽  
Author(s):  
Yavuz Beyazit ◽  
Abdurrahim Sayilir ◽  
Murat Kekilli ◽  
Mevlut Kurt ◽  
Orhan Gorgulu
Keyword(s):  
Alcoholic Hepatitis ◽  
Kinase Inhibition ◽  
Acute Alcoholic Hepatitis ◽  
Phosphoinositide 3 Kinase

scholarly journals Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets but reverses platelet aggregation

1995 ◽  
Vol 270 (19) ◽  
pp. 11358-11366 ◽  
Author(s):  
TJ Kovacsovics ◽  
C Bachelot ◽  
A Toker ◽  
CJ Vlahos ◽  
B Duckworth ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Actin Assembly ◽  
Kinase Inhibition ◽  
Phosphoinositide 3 Kinase

scholarly journals Isoform-selective phosphoinositide 3-kinase inhibition ameliorates a broad range of fragile X syndrome-associated deficits in a mouse model

2018 ◽  
Vol 44 (2) ◽  
pp. 324-333 ◽  
Author(s):  
Christina Gross ◽  
Anwesha Banerjee ◽  
Durgesh Tiwari ◽  
Francesco Longo ◽  
Angela R. White ◽  
...  
Keyword(s):  
Mouse Model ◽  
Fragile X Syndrome ◽  
Fragile X ◽  
Kinase Inhibition ◽  
Phosphoinositide 3 Kinase
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