scholarly journals Prolonged inhibition of hepatocellular carcinoma cell proliferation by combinatorial expression of defined transcription factors

2018 ◽  
Vol 109 (11) ◽  
pp. 3543-3553 ◽  
Author(s):  
Yasuo Takashima ◽  
Kenichi Horisawa ◽  
Miyako Udono ◽  
Yasuyuki Ohkawa ◽  
Atsushi Suzuki
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Proliferation ◽  
Transcription Factors ◽  
Carcinoma Cell ◽  
Hepatocellular Carcinoma Cell ◽  
Combinatorial Expression

Novel small molecular inhibitor of Pit-Oct-Unc transcription factor 1 suppresses hepatocellular carcinoma cell proliferation

Life Sciences ◽  
2021 ◽  
pp. 119521
Author(s):  
Yue Wang ◽  
Shuo Liu ◽  
Qin Chen ◽  
Yixin Ren ◽  
Zhongxiang Li ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Proliferation ◽  
Transcription Factor ◽  
Carcinoma Cell ◽  
Hepatocellular Carcinoma Cell ◽  
Transcription Factor 1

EGFL7 promotes hepatocellular carcinoma cell proliferation and inhibits cell apoptosis through increasing CKS2 expression by activating Wnt/β‐catenin signaling

2018 ◽  
Vol 119 (12) ◽  
pp. 10327-10337 ◽  
Author(s):  
Zhi Li ◽  
Tong‐Qing Xue ◽  
Chao Yang ◽  
Yun‐Liang Wang ◽  
Xiao‐Li Zhu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Proliferation ◽  
Cell Apoptosis ◽  
Carcinoma Cell ◽  
Hepatocellular Carcinoma Cell

ARID1A represses hepatocellular carcinoma cell proliferation and migration through lncRNA MVIH

2017 ◽  
Vol 491 (1) ◽  
pp. 178-182 ◽  
Author(s):  
Sheng Cheng ◽  
Lan Wang ◽  
Chuan-Huai Deng ◽  
Shi-Chun Du ◽  
Ze-Guang Han
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Proliferation ◽  
Carcinoma Cell ◽  
Cell Proliferation And Migration ◽  
Hepatocellular Carcinoma Cell ◽  
And Migration ◽  
Proliferation And Migration

scholarly journals MiR-223 modulates hepatocellular carcinoma cell proliferation through promoting apoptosis via the Rab1-mediated mTOR activation

2017 ◽  
Vol 483 (1) ◽  
pp. 630-637 ◽  
Author(s):  
Zheng Dong ◽  
Ruizhao Qi ◽  
Xiaodong Guo ◽  
Xin Zhao ◽  
Yinyin Li ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Proliferation ◽  
Carcinoma Cell ◽  
Hepatocellular Carcinoma Cell

Specificity and potency of curcumin derivative 64PH in inhibiting HepG2 human hepatocellular carcinoma cell proliferation

2017 ◽  
Vol 2 (1) ◽  
pp. 1 ◽  
Author(s):  
Junwang Xu ◽  
Weiyi Feng ◽  
Xueqian Li ◽  
Qiaowei Zheng ◽  
Yingchen Zhuo ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Proliferation ◽  
Carcinoma Cell ◽  
Human Hepatocellular Carcinoma ◽  
Human Hepatocellular Carcinoma Cell ◽  
Hepatocellular Carcinoma Cell ◽  
Curcumin Derivative

scholarly journals Dihydroartemisinin Inhibits Proliferation and Induces Apoptosis of Human Hepatocellular Carcinoma Cell by Upregulating Tumor Necrosis Factor via JNK/NF-κB Pathways

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Long Wu ◽  
Yanlei Cheng ◽  
Junjian Deng ◽  
Weiping Tao ◽  
Junjie Ye
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Proliferation ◽  
Differentially Expressed Genes ◽  
Carcinoma Cell ◽  
Expression Profiles ◽  
Human Hepatocellular Carcinoma ◽  
Differentially Expressed ◽  
Venn Diagram ◽  
Dependent Manner ◽  
Hepatocellular Carcinoma Cell

Background. Dihydroartemisinin (DHA) is a predominant compound in Artemisia annua L., and it has been shown to inhibit tumorigenesis. Methods. In this study, the antitumor potential of DHA was investigated in the MHCC97-L hepatocellular carcinoma cell line. Cells were treated at various concentrations of DHA, and then the cell cycle, viability, and DNA synthesis were measured to evaluate cell proliferation. Furthermore, the expression of genes and proteins related to proliferation and apoptosis was measured to determine the effects of DHA. Finally, the mechanism was investigated using RNA-sequencing to identify differentially expressed genes and signaling pathways, and JNK/NF-κB pathways were evaluated with Western blotting. Results. Cells were treated with a concentration range of DHA from 1 to 100 μM, and cell proliferation was suppressed in a dose-dependent manner. In addition, the genes and proteins involved in typical cellular functions of MHCC97-L cells were significantly inhibited. DHA treatment downregulated the angiogenic gene ANGPTL2 and the cell proliferation genes CCND1, E2F1, PCNA, and BCL2. DHA treatment significantly upregulated the apoptotic genes CASP3, CASP8, CASP9, and TNF. Global gene expression profiles identified 2064 differentially expressed genes (DEGs). Among them, 744 were upregulated and 1320 were downregulated. Furthermore, MAPK, NF-kappa B, and TNF pathways were enriched based on the DEGs, and the consensus DEG was identified as TNF using a Venn diagram of those pathways. DHA promoted phosphorylation of JNK, inhibited nuclear p65, and then significantly induced TNF-α synthesis. Conclusion. DHA inhibited cell proliferation and induced apoptosis in human hepatocellular carcinoma cells by upregulating TNF expression via JNK/NF-κB pathways.

Sign in / Sign up

Export Citation Format

Share Document