scholarly journals Farnesyltransferase inhibitor FTI-277 inhibits PD-L1 expression on septic spleen lymphocytes and promotes spleen lymphocyte activation

2017 ◽  
Vol 190 (1) ◽  
pp. 8-18 ◽  
Author(s):  
W. Li ◽  
J. Tu ◽  
X. Liu ◽  
W. Yang
Keyword(s):  
Lymphocyte Activation ◽  
Spleen Lymphocyte ◽  
Farnesyltransferase Inhibitor ◽  
Spleen Lymphocytes

scholarly journals Relationship between the fatty acid composition of rat lymphocytes and immune functions

2000 ◽  
Vol 83 (3) ◽  
pp. 327-333 ◽  
Author(s):  
Marguerite Moussa ◽  
Jean Tkaczuk ◽  
Jeannie Ragab ◽  
Jésus Garcia ◽  
Michel Abbal ◽  
...  
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Interleukin 2 ◽  
Lymphocyte Activation ◽  
Proliferation Index ◽  
The Mean ◽  
Spleen Lymphocytes ◽  
Fat Diets ◽  
Cell Proliferation Index

The effects of dietary lipids on the fatty acid composition, activation and proliferation of lymphocytes were investigated. Weanling male Wistar rats were fed for 8 weeks on one of two low-fat diets which contained 50 g lipid/kg, or one of two high-fat diets containing 200 g lipid/kg, from either coconut oil or soyabean oil. The fatty acid composition of phospholipids from splenocyte membranes was affected by dietary lipid manipulation, and these differences influenced lymphocyte functions. Increased levels of linoleic acid in spleen lymphocytes correlated negatively with interleukin-2 receptor α-chain expression determined either by measuring the mean fluorescence or by the proportion of cells staining positive for CD25, and with the cell proliferation index. However, we found a positive correlation between interleukin-2 receptor α-chain expression determined by measuring the mean fluorescence and the cell proliferation index with the oleic acid concentration of spleen lymphocytes. Since phospholipid hydrolysis occurs early in lymphocyte activation, immunosuppressive effects induced by polyunsaturated fatty acids, described in the literature, could be due to an increase of linoleic acid or a decrease of oleic acid affecting many components of plasma-membrane-associated events involved in lymphocyte activation.

Binding of chemical derivatives of Phaseolus vulgaris phytohemagglutinin to pig spleen lymphocytes

1980 ◽  
Vol 58 (5) ◽  
pp. 399-404 ◽  
Author(s):  
Gilles Dupuis ◽  
Sylvie Clairoux-Moreau
Keyword(s):  
Phaseolus Vulgaris ◽  
Binding Sites ◽  
Lectin Binding ◽  
Lymphocyte Activation ◽  
Binding Studies ◽  
Chemical Derivatives ◽  
Nitro Derivatives ◽  
Spleen Lymphocytes ◽  
Derivatives Of ◽  
Apparent Association

The mitogenic activity of Phaseolus vulgaris phytohemagglutinin (PHA) and its acetyl, citraconyl, glycinyl, homoarginyl, N-bromosuccinimide, and nitro derivatives has been assayed using pig spleen lymphocytes. Nitrated and N-bromosuccinimide-treated PHA were not mitogenic. Whereas the mitogenicity of acetyl PHA was impaired, the other derivatives were as active as untreated lectin. Binding studies of [125I]PHA and derivatives to purified pig spleen lymphocytes were performed at 37 °C. Results show that the lymphocytes bound various amounts of lectin derivatives. Maximum amounts were observed in the case of mitogenic lectins. Data were analyzed by Scatchard plots and two kinds of binding sites were found for PHA and the mitogenic derivatives. High affinity and low affinity binding sites have been characterized in terms of (apparent) association constant and (apparent) number of sites. Binding of PHA or its chemical derivatives to a small fraction (4.6–9.0%) of all available lectin binding sites was sufficient for maximal lymphocyte stimulation. Nonmitogenic PHA derivatives (nitro or N-bromosuccinimide) bound, with low affinity, to one kind of binding site. The relevancy of these findings to lymphocyte activation is discussed.

The Effect of Partial Splenectomy on Platelet Production in Mice

1981 ◽  
Vol 46 (03) ◽  
pp. 602-603 ◽  
Author(s):  
H Bessler ◽  
I Notti ◽  
M Djaldetti
Keyword(s):  
Peripheral Blood ◽  
Blood Platelets ◽  
Operative Procedures ◽  
Partial Splenectomy ◽  
Splenic Lymphocytes ◽  
Platelet Production ◽  
Platelet Number ◽  
Spleen Lymphocytes

SummaryThe effect of total and partial splenectomy on the number and production of circulating platelets was studied in mice. Five days after total and partial splenectomy the number of the peripheral blood platelets increased by 87% and 60%, respectively and the incorporation of 75selenium methionine (75Se-Met) into platelets was enhanced indicating that the thrombocytosis was due to increased platelet production. The results obtained by the two operative procedures were compared.Since previous work from our laboratory has shown that a factor produced by splenic lymphocytes affects the platelet number in mice, it is suggested that the differences in the number of circulating platelets observed in animals after total and partial splenectomy may reflect a difference in the number of spleen lymphocytes removed.

Enhancement of Lymphocyte Activation by Inflammatory Exudate Cells

1974 ◽  
Vol 36 (4) ◽  
pp. 481-487
Author(s):  
Masaru YOSHINAGA ◽  
Shuji NAKAMURA ◽  
Yasunori HIGUCHI
Keyword(s):  
Lymphocyte Activation ◽  
Inflammatory Exudate

UVC-induced damage in mouse spleen lymphocytes and anti-radiation effect of exogenous nucleotides

2014 ◽  
Author(s):  
Cuilin Cheng ◽  
Zhenyu Wang ◽  
Haitian Zhao ◽  
Aiju Hou ◽  
Rongchun Wang ◽  
...  
Keyword(s):  
Radiation Effect ◽  
Mouse Spleen ◽  
Spleen Lymphocytes

Lymphocyte Activation, Iron Uptake and Release by Human Mononuclear Leukocytes in Tiie Presence of Desferrioxamine

1986 ◽  
Vol 2 (1) ◽  
pp. 165-178
Author(s):  
Peter G. Taylor ◽  
AndrÉS Soyano ◽  
Egidio Romano ◽  
Miguel Layrisse
Keyword(s):  
Iron Uptake ◽  
Lymphocyte Activation ◽  
Mononuclear Leukocytes ◽  
Human Mononuclear Leukocytes ◽  
Uptake And Release

Prediction of invasion sclera uveal melanoma using molecular markers lymphocyte activation

2013 ◽  
Vol 44 (4) ◽  
pp. 30-34
Author(s):  
L. Velichko ◽  
◽  
V. Vit ◽  
A. Malecki ◽  
E. Dragomiretskaya ◽  
...  
Keyword(s):  
Molecular Markers ◽  
Uveal Melanoma ◽  
Lymphocyte Activation
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