The clinical diagnostic value of target biopsy using narrow-band imaging endoscopy and accurate laryngeal carcinoma pathologic specimen acquisition

Abstract Aim White globe appearance (WGA), a small white lesion with a globular shape that can be clearly visualized by magnifying endoscopy with narrow-band imaging (ME-NBI), was reported to be a reliable marker of early gastric cancer (EGC). However, we found that this endoscopic presentation could also be seen in non-cancerous tissues, especially in ulcerative lesions. This study aimed to further investigate the diagnostic value of WGA in differentiating non-cancerous lesions from EGC in ulcer-type cases. Materials and Methods We retrospectively reviewed 54 cases of EGC and 155 cases of non-cancerous lesions in this study, all of which had endoscopic imaging data of ME-NBI scanning and pathological data of biopsy or resected specimens. The correlation of the prevalence of WGA and ulcerative lesions, as well as the characteristics of WGA between the 2 groups were analyzed in this study. Results WGA was more common in ulcerative lesions (27.6 %, 21/76) than in non-ulcerative lesions (3.8 %, 5/133) (p < 0.001) in our study. In the ulcerative cases, no significant difference in prevalence of WGA was observed between EGC and non-cancerous lesions (p = 0.532). Compared with WGA in EGC, WGA in non-cancerous lesions tended to show the characteristic of tree-branch-like vessels on globular shape (p < 0.001). Conclusions WGA is more likely to occur in ulcerative lesions, and the presence of WGA alone cannot distinguish EGC from non-cancerous lesions in ulcer-type cases. In WGA-positive tissue, tree-branch-like vessels of globular shape may provide a certain clinical value in diagnosis of non-cancerous lesions or EGC.

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Clinical experience of narrow band imaging (NBI) usage in diagnosis of laryngeal lesions

Otolaryngologia Polska ◽

10.5604/01.3001.0013.3401 ◽

2019 ◽

Vol 73 (6) ◽

pp. 18-23 ◽

Cited By ~ 1

Author(s):

Barbara Popek ◽

Katarzyna Bojanowska-Poźniak ◽

Bartłomiej Tomasik ◽

Wojciech Fendler ◽

Joanna Jeruzal-Świątecka ◽

...

Keyword(s):

White Light ◽

Narrow Band ◽

Histopathological Examination ◽

Narrow Band Imaging ◽

Daily Practice ◽

Diagnostic Value ◽

Severe Dysplasia ◽

White Light Endoscopy ◽

Laryngeal Lesions ◽

Sensitivity Specificity

Introduction: One of the most recent methods used in imaging of the larynx is narrow band imaging (NBI). NBI enables us to detect specific patterns of pathological angiogenesis suggestive of premalignant or neoplastic lesions. The aim of the study was to compare imaging of laryngeal lesions in white light endoscopy (WLE) and NBI in relation to histopathological examination. Material and methods: 333 patients with laryngeal lesions underwent endoscopic evaluation in WLE and NBI. Sensitivity, specificity, positive and negative predictive value (PPV, NPV) for WLE and NBI were calculated. The diagnostic value for WLE and NBI was evaluated for two assumptions (positive result is:1. severe dysplasia and cancer 2. only cancer) Results: Sensitivity, specificity, PPV, NPV of first assumption were respectively for white light compared to NBI: 95.4% vs 98.5%; 84.2% vs 98.5%; 79.6% vs 97.7% and 96.6% vs 99.0%. The values of second assumption were: 97.4% vs 100%; 79.3% vs 93.5%; 72.6% vs. 89.4% and 98.2% vs. 100.0%. Higher sensitivity was observed for the second assumption, while higher specifity was recorded for the first assumption. Specificity was significantly higher for NBI than for WLE (p<0.001). Conclusions: NBI enables us to detect and differentiate laryngeal lesions, which are invisible in WLE. Endoscopic examination, especially in NBI-mode, is non-invasive, repeatable and remains a useful tool in the daily practice and diagnosis of patients with pathological lesions in the larynx.

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The Diagnostic Value of Narrow-Band Imaging for the Detection of Nasopharyngeal Carcinoma

ORL ◽

10.1159/000342277 ◽

2012 ◽

Vol 74 (5) ◽

pp. 235-239 ◽

Cited By ~ 11

Author(s):

Haidi Yang ◽

Yiqing Zheng ◽

Qiujian Chen ◽

Hao Xiong ◽

Bin Chen ◽

...

Keyword(s):

Nasopharyngeal Carcinoma ◽

Narrow Band ◽

Narrow Band Imaging ◽

Diagnostic Value

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Diagnostic Value and Pathological Correlation of Narrow Band Imaging Classification in Laryngeal Lesions

Ear Nose & Throat Journal ◽

10.1177/0145561320925327 ◽

2020 ◽

pp. 014556132092532 ◽

Cited By ~ 1

Author(s):

Chuanyao Lin ◽

Sisi Zhang ◽

Ling Lu ◽

Maohua Wang ◽

Xiaoyun Qian

Keyword(s):

Predictive Value ◽

Narrow Band ◽

Narrow Band Imaging ◽

Diagnostic Value ◽

Pathological Correlation ◽

Laryngeal Lesions ◽

Loop Pattern ◽

Malignant Lesions ◽

High Consistency ◽

Sensitivity Specificity

Objectives: To explore the diagnostic value and pathological correlation of narrow band imaging (NBI) classification in laryngeal lesions. Methods: A total of 112 patients (123 lesions) with laryngeal lesions from July 2018 to May 2019 were selected in this study. All patients were examined by NBI and white light imaging endoscopy. The NBI endoscopy was applied to classify the observed lesion sites according to intraepithelial papillary capillary loop pattern. The gold standard of diagnosis was pathological results. To evaluate the consistency of NBI classification and pathological results. Results: The sensitivity, specificity, positive predictive value, and negative predictive value of the diagnosis for benign, precancerous, and malignant lesions under the NBI endoscopy were 90.91%, 81.19%, 74.07%, 85.42%; 41.67%, 92.93%, 58.82%, 86.79%; and 93.51%, 65.22%, 91.14%, 68.18%, respectively. There was a high consistency between NBI classification and pathological results (κ = 0.679, P < .001). Conclusions: The NBI classification can improve the accuracy of the diagnosis of laryngeal lesions. It is important for early diagnosis and treatment of vocal cord leukoplakia and laryngeal cancer.

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