scholarly journals Diagnostic Value and Pathological Correlation of Narrow Band Imaging Classification in Laryngeal Lesions

2020 ◽  
pp. 014556132092532 ◽  
Author(s):  
Chuanyao Lin ◽  
Sisi Zhang ◽  
Ling Lu ◽  
Maohua Wang ◽  
Xiaoyun Qian
Keyword(s):  
Predictive Value ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Diagnostic Value ◽  
Pathological Correlation ◽  
Laryngeal Lesions ◽  
Loop Pattern ◽  
Malignant Lesions ◽  
High Consistency ◽  
Sensitivity Specificity

Objectives: To explore the diagnostic value and pathological correlation of narrow band imaging (NBI) classification in laryngeal lesions. Methods: A total of 112 patients (123 lesions) with laryngeal lesions from July 2018 to May 2019 were selected in this study. All patients were examined by NBI and white light imaging endoscopy. The NBI endoscopy was applied to classify the observed lesion sites according to intraepithelial papillary capillary loop pattern. The gold standard of diagnosis was pathological results. To evaluate the consistency of NBI classification and pathological results. Results: The sensitivity, specificity, positive predictive value, and negative predictive value of the diagnosis for benign, precancerous, and malignant lesions under the NBI endoscopy were 90.91%, 81.19%, 74.07%, 85.42%; 41.67%, 92.93%, 58.82%, 86.79%; and 93.51%, 65.22%, 91.14%, 68.18%, respectively. There was a high consistency between NBI classification and pathological results (κ = 0.679, P < .001). Conclusions: The NBI classification can improve the accuracy of the diagnosis of laryngeal lesions. It is important for early diagnosis and treatment of vocal cord leukoplakia and laryngeal cancer.

Clinical experience of narrow band imaging (NBI) usage in diagnosis of laryngeal lesions

2019 ◽  
Vol 73 (6) ◽  
pp. 18-23 ◽  
Author(s):  
Barbara Popek ◽  
Katarzyna Bojanowska-Poźniak ◽  
Bartłomiej Tomasik ◽  
Wojciech Fendler ◽  
Joanna Jeruzal-Świątecka ◽  
...  
Keyword(s):  
White Light ◽  
Narrow Band ◽  
Histopathological Examination ◽  
Narrow Band Imaging ◽  
Daily Practice ◽  
Diagnostic Value ◽  
Severe Dysplasia ◽  
White Light Endoscopy ◽  
Laryngeal Lesions ◽  
Sensitivity Specificity

Introduction: One of the most recent methods used in imaging of the larynx is narrow band imaging (NBI). NBI enables us to detect specific patterns of pathological angiogenesis suggestive of premalignant or neoplastic lesions. The aim of the study was to compare imaging of laryngeal lesions in white light endoscopy (WLE) and NBI in relation to histopathological examination. Material and methods: 333 patients with laryngeal lesions underwent endoscopic evaluation in WLE and NBI. Sensitivity, specificity, positive and negative predictive value (PPV, NPV) for WLE and NBI were calculated. The diagnostic value for WLE and NBI was evaluated for two assumptions (positive result is:1. severe dysplasia and cancer 2. only cancer) Results: Sensitivity, specificity, PPV, NPV of first assumption were respectively for white light compared to NBI: 95.4% vs 98.5%; 84.2% vs 98.5%; 79.6% vs 97.7% and 96.6% vs 99.0%. The values of second assumption were: 97.4% vs 100%; 79.3% vs 93.5%; 72.6% vs. 89.4% and 98.2% vs. 100.0%. Higher sensitivity was observed for the second assumption, while higher specifity was recorded for the first assumption. Specificity was significantly higher for NBI than for WLE (p<0.001). Conclusions: NBI enables us to detect and differentiate laryngeal lesions, which are invisible in WLE. Endoscopic examination, especially in NBI-mode, is non-invasive, repeatable and remains a useful tool in the daily practice and diagnosis of patients with pathological lesions in the larynx.

scholarly journals The Impact of Narrow-band Imaging on the Pre- and Intra- operative Assessments of Neoplastic and Preneoplastic Laryngeal Lesions. A Systematic Review

2020 ◽  
Author(s):  
Carmelo Saraniti ◽  
Enzo Chianetta ◽  
Giuseppe Greco ◽  
Norhafiza Mat Lazim ◽  
Barbara Verro
Keyword(s):  
White Light ◽  
Diagnostic Tool ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Resection Margins ◽  
Predictive Values ◽  
White Light Endoscopy ◽  
Laryngeal Lesions ◽  
Sensitivity Specificity ◽  
The Impact

Introduction Narrow-band imaging is an endoscopic diagnostic tool that, focusing on superficial vascular changes, is useful to detect suspicious laryngeal lesions, enabling their complete excision with safe and tailored resection margins. Objectives To analyze the applications and benefits of narrow-band imaging in detecting premalignant and malignant laryngeal lesions through a comparison with white-light endoscopy. Data Synthesis A literature search was performed in the PubMed, Scopus and Web of Science databases using strict keywords. Then, two authors independently analyzed the articles, read the titles and abstracts, and read completely only the relevant studies according to certain eligibility criteria. In total, 14 articles have been included in the present review; the sensitivity, specificity, positive and negative predictive values, and accuracy of pre- and/or intraoperative narrow-band imaging were analyzed. The analysis showed that narrow-band imaging is better than white-light endoscopy in terms of sensitivity, specificity, positive and negative predictive values, and accuracy regarding the ability to identify cancer and/or precancerous laryngeal lesions. Moreover, the intraoperative performance of narrow-band imaging resulted more effective than the in-office performance. Conclusion Narrow-band imaging is an effective diagnostic tool to detect premalignant and malignant laryngeal lesions and to define proper resection margins. Moreover, narrow-band imaging is useful in cases of leukoplakia that may cover a possible malignant lesion and that cannot be easily assessed with white-light endoscopy. Finally, a shared, simple and practical classification of laryngeal lesions, such as that of the European Laryngological Society, is required to identify a shared lesion management strategy. Key Points

scholarly journals Manual versus Automatic Classification of Laryngeal Lesions based on Vascular Patterns in CE+NBI Images

2020 ◽  
Vol 6 (3) ◽  
pp. 70-73
Author(s):  
Nazila Esmaeili ◽  
Alfredo Illanes ◽  
Axel Boese ◽  
Nikolaos Davaris ◽  
Christoph Arens ◽  
...  
Keyword(s):  
Vocal Fold ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Automatic Classification ◽  
Vascular Pattern ◽  
Objective Interpretation ◽  
Laryngeal Lesions ◽  
Malignant Lesions ◽  
Manual Classification

AbstractLongitudinal and perpendicular changes in the blood vessels of the vocal fold have been related to the advancement from benign to malignant laryngeal cancer stages. The combination of Contact Endoscopy (CE) and Narrow Band Imaging (NBI) provides intraoperative realtime visualization of vascular pattern in Larynx. The evaluation of these vascular patterns in CE+NBI images is a subjective process leading to differentiation difficulty and subjectivity between benign and malignant lesions. The main objective of this work is to compare multi-observer classification versus automatic classification of laryngeal lesions. Six clinicians visually classified CE+NBI images into benign and malignant lesions. For the automatic classification of CE+NBI images, we used an algorithm based on characterizing the level of the vessel’s disorder. The results of the manual classification showed that there is no objective interpretation, leading to difficulties to visually distinguish between benign and malignant lesions. The results of the automatic classification of CE+NBI images on the other hand showed the capability of the algorithm to solve these issues. Based on the observed results we believe that, the automatic approach could be a valuable tool to assist clinicians to classifying laryngeal lesions.

scholarly journals The “Pink Pattern” Visualized in Magnifying Endoscopy with Narrow-Band Imaging is a New Feature of Early Gastric Differentiated Cancer——A Bridge Between Endoscopic Image and Histopathological Change

2021 ◽  
Author(s):  
Shengsen Chen ◽  
Jiangping Yu ◽  
Rongwei Ruan ◽  
Yali Tao ◽  
Zhao Cui ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Epithelial Cells ◽  
Predictive Value ◽  
Color Change ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Magnifying Endoscopy ◽  
Cosine Similarity ◽  
Diagnostic Efficiency ◽  
Sensitivity Specificity

Abstract Background A pink color change found occasionally by us under the magnifying endoscopy with narrow-band imaging (ME-NBI) may be a special feature of early gastric cancer (EGC), and it was named as “pink pattern”. The purposes of this study were to reveal the relationship between the “pink pattern” and the cytopathological changes of gastric cancer cells, and explore whether the pink pattern was useful for the diagnosis of EGC. Methods The color features of ME-NBI images and pathological images on gastric cancerous mucosal surface were extracted and quantized, and then the cosine similarity was calculated to evaluate the correlation between the pink pattern and the nucleus-to-plasm ratio of cancerous epithelial cells. Two diagnostic tests were performed by 12 endoscopists using stored ME-NBI images of 185 gastric lesions to investigate the diagnostic efficiency of “pink pattern” for EGC. The diagnostic values such as area under curve (AUC), accuracy, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) between test 1 and test 2 were compared. Results The cosine similarity in 20 lesions between the color values of ME-NBI images and pathological images was at least 0.744. The median AUC, accuracy, sensitivity, specificity, PPV and NPV of test 2 were significantly improved compared with that of test 1 in all endoscopists, junior and experienced groups. Conclusions The “pink pattern” visualized in ME-NBI images is highly correlated with the nucleus-to-plasma ratio change of gastric epithelial cells, and it can be considered as a useful marker for the diagnosis of the differentiated EGC.

scholarly journals “Pink Pattern” Visualized in Magnifying Endoscopy With Narrow-Band Imaging Is a Novel Feature of Early Differentiated Gastric Cancer: A Bridge Between Endoscopic Images and Histopathological Changes

2021 ◽  
Vol 8 ◽  
Author(s):  
Shengsen Chen ◽  
Jiangping Yu ◽  
Rongwei Ruan ◽  
Yandong Li ◽  
Yali Tao ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Epithelial Cells ◽  
Predictive Value ◽  
Color Change ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Magnifying Endoscopy ◽  
Cosine Similarity ◽  
Gastric Cancer Cells ◽  
Sensitivity Specificity

Background: A pink color change occasionally found by us under magnifying endoscopy with narrow-band imaging (ME-NBI) may be a special feature of early gastric cancer (EGC), and was designated the “pink pattern”. The purposes of this study were to determine the relationship between the pink pattern and the cytopathological changes in gastric cancer cells and whether the pink pattern is useful for the diagnosis of EGC.Methods: The color features of ME-NBI images and pathological images of cancerous gastric mucosal surfaces were extracted and quantified. The cosine similarity was calculated to evaluate the correlation between the pink pattern and the nucleus-to-cytoplasm ratio of cancerous epithelial cells. Two diagnostic tests were performed by 12 endoscopists using stored ME-NBI images of 185 gastric lesions to investigate the diagnostic efficacy of the pink pattern for EGC. The diagnostic values, such as the area under the curve (AUC), the accuracy, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV), of test 1 and test 2 were compared.Results: The cosine similarity between the color values of ME-NBI images and pathological images of 20 lesions was at least 0.744. The median AUC, accuracy, sensitivity, specificity, PPV, and NPV of test 2 were significantly better than those of test 1 for all endoscopists and for the junior and experienced groups.Conclusions: The pink pattern observed in ME-NBI images correlated strongly with the change in the nucleus-to-cytoplasm ratio of gastric epithelial cells, and could be considered a useful marker for the diagnosis of differentiated EGC.

scholarly journals Ultra-magnifying narrow-band imaging for endoscopic diagnosis of gastric intestinal metaplasia: a pilot image analysis study

2021 ◽  
Vol 09 (04) ◽  
pp. E522-E529
Author(s):  
Hiroyoshi Iwagami ◽  
Noriya Uedo ◽  
Hon-Chi Yip ◽  
Satoki Shichijo ◽  
Takashi Kanesaka ◽  
...  
Keyword(s):  
Intestinal Metaplasia ◽  
Cellular Structure ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Diagnostic Value ◽  
Gastric Intestinal Metaplasia ◽  
Crypt Epithelium ◽  
Diagnostic Values ◽  
Sensitivity Specificity ◽  
A Prospective Study

Abstract Background and study aims Narrow-band imaging (NBI) with or without magnification has recently been used for diagnosis of gastric intestinal metaplasia (GIM). Endocytoscopy is a newly developed endoscopic technique that enables ultra-high (500 ×) magnification of the digestive tract mucosa. This study aimed to analyze the ultra-magnifying NBI characteristics of GIM. Patients and methods This was a retrospective observational study conducted in a cancer referral center. Patients who underwent ultra-magnifying NBI of the gastric mucosa using endocytoscopy were eligible. A soft black cap was used for non-contact observation. We compared the characteristic findings of GIM by ultra-magnifying NBI of metaplastic and non-metaplastic mucosae. A reference standard for GIM in this study was conventional magnifying NBI findings of GIM. Results We obtained 28 images of metaplastic mucosa and 32 of non-metaplastic mucosa from 38 patients. Ultra-magnifying NBI revealed the cobblestone-like cellular structure in the marginal crypt epithelium of metaplastic and non-metaplastic mucosa. Diagnostic values (sensitivity, specificity, accuracy and kappa value [95 % confidence interval]) for the heterogeneous cellular structure and rough contour of the marginal crypt epithelium were 82 % (68 %–96 %), 94 % (85 %–100 %), 88 % (80 %–96 %), and 0.70, and 86 % (73 %–99 %), 94 % (85 %–100 %), 90 % (82 %–98 %), and 0.71, respectively. Conclusions The characteristic ultrastructural features of GIM were identified by ultra-magnifying NBI, warranting validation of diagnostic value in a prospective study.

scholarly journals Evaluation of Microvascular Patterns Alone Using Endocytoscopy with Narrow-Band Imaging for Diagnosing Gastric Cancer

Digestion ◽  
2021 ◽  
pp. 1-10
Author(s):  
Yusuke Horiuchi ◽  
Toshiaki Hirasawa ◽  
Naoki Ishizuka ◽  
Junki Tokura ◽  
Mitsuaki Ishioka ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Predictive Value ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Diagnostic System ◽  
Validation Group ◽  
Specific Training ◽  
Sensitivity Specificity ◽  
Development And Validation ◽  
Development Group

<b><i>Introduction:</i></b> Although endocytoscopy (EC) with narrow-band imaging (NBI) is effective in diagnosing gastric cancer, no diagnostic system has been validated. We explored a specific diagnostic system for gastric cancer using EC with NBI. <b><i>Methods:</i></b> Equal numbers of images from cancerous and noncancerous areas (114 images each) were assessed by endoscopists with (development group: 33) and without (validation group: 28) specific training in magnifying endoscopy with NBI. Microvascular and microsurface patterns (MS) in each image were evaluated. Lesions were diagnosed as cancerous when patterns were deemed “irregular.” The accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of a diagnosis according to patterns on EC with NBI (microvascular pattern [MV] alone, MS alone, and both) were evaluated and compared between groups to determine the diagnostic performance. <b><i>Results:</i></b> In the development and validation groups, diagnoses based on the MV alone had significantly higher accuracy (91.7% vs. 76.3%, <i>p</i> &#x3c; 0.0001 and 92.5% vs. 67.5%, <i>p</i> &#x3c; 0.0001, respectively) and sensitivity (88.6% vs. 68.3%, <i>p</i> &#x3c; 0.0001 and 89.5% vs. 38.6%, <i>p</i> &#x3c; 0.0001, respectively) than those based on the MS alone. In both groups, there were no significant differences in diagnostic accuracy between using the MV alone and both patterns. <b><i>Discussion/Conclusion:</i></b> Evaluation of the MV alone is a simple and accurate diagnostic method for gastric cancer. This system could find widespread applications in clinical practice.

scholarly journals Diagnostic Value of Narrow Band Imaging in Visualization of Pathological Lesions in Larynx and Hypopharynx

2021 ◽  
Vol 64 (1) ◽  
pp. 22-28
Author(s):  
Jana Šatanková ◽  
Lucia Staníková ◽  
Anna Švejdová ◽  
Michal Černý ◽  
Jan Laco ◽  
...  
Keyword(s):  
White Light ◽  
Predictive Value ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Precancerous Lesions ◽  
Histopathological Analysis ◽  
White Light Endoscopy ◽  
Group A ◽  
Malignant Lesions ◽  
Group B

Introduction: Narrow Band Imaging (NBI) is an endoscopic optical imaging enhancement technology that improves the contrast of mucosal surface texture and enhances visualization of mucosal and submucosal vasculature. Due to its properties, it can visualize suspected malignant or precancerous lesions earlier than conventional white light endoscopy. The aim of this study was to analyze the benefit of NBI in visualization of precancerous and malignant lesions in preoperative and intraoperative diagnostics and correlation with histopathologic results. Methods: A total of 589 patients with suspicious laryngeal or hypopharyngeal lesion were investigated using conventional white light endoscopy (WLE) and NBI endoscopy with high-definition TV (HDTV NBI) from 10/2013 to 12/2019. Patients were divided into two groups based on pre-operative NBI examination (group A, 345 patients) and intraoperative NBI examination (group B, 244 patients). All suspicious lesions were graded to 5 types of Ni classification and correlated with histopathologic results. The SPSS version 8.0.4 statistical software package was used for statistical analysis. In diagnosing premalignant and malignant lesions sensitivity, specificity, positive predictive value, and negative predictive value were calculated. Results: The agreement between NBI endoscopy and histopathological analysis in group A was statistically significant (Қ = 0.76, p < 0.001), with a sensitivity of 86.2% (95% IS: 65.4–95.2) and specificity of 90.9% (95% IS: 70.6–94.1). Moreover, in group B was proven almost perfect agreement between NBI and histopathological analysis (Қ = 0.8461, p < 0.001), with a sensitivity of 84.0% (95% IS: 60.2–92.4) and specificity of 96.0% (95% IS: 87.0–99.2). Conclusions: Based on our results, NBI using the Ni classification has great potential in improving diagnosis of precancerous and malignant lesions and correlates strongly with histopathologic results. It serves as a useful adjunct to white light endoscopy in the diagnosis of laryngeal and hypopharyngeal lesions, especially using HDTV NBI.

scholarly journals Validation of the European Laryngological Society classification of glottic vascular changes as seen by narrow band imaging in the optical biopsy setting

2021 ◽  
Author(s):  
Francesco Missale ◽  
Stefano Taboni ◽  
Andrea Luigi Camillo Carobbio ◽  
Francesco Mazzola ◽  
Giulia Berretti ◽  
...  
Keyword(s):  
Test Performance ◽  
Predictive Value ◽  
Interobserver Agreement ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Intraepithelial Neoplasia ◽  
Optical Biopsy ◽  
Vascular Changes ◽  
Laryngeal Lesions ◽  
European Laryngological Society

Abstract Purpose In 2016, the European Laryngological Society (ELS) proposed a classification for vascular changes occurring in glottic lesions as visible by narrow band imaging (NBI), based on the dichotomic distinction between longitudinal vessels (not suspicious) and perpendicular ones (suspicious). The aim of our study was to validate this classification assessing the interobserver agreement and diagnostic test performance in detecting the final histopathology. Methods A retrospective study was carried out by reviewing clinical charts, preoperative videos, and final pathologic diagnosis of patients submitted to transoral microsurgery for laryngeal lesions in two Italian referral centers. In each institution, two physicians, independently re-assessed each case applying the ELS classification. Results The cohort was composed of 707 patients. The pathologic report showed benign lesions in 208 (29.5%) cases, papillomatosis in 34 (4.8%), squamous intraepithelial neoplasia (SIN) up to carcinoma in situ in 200 (28.2%), and squamous cell carcinoma (SCC) in 265 (37.5%). The interobserver agreement was extremely high in both institutions (k = 0.954, p < 0.001 and k = 0.880, p < 0.001). Considering the diagnostic performance for identification of at least SIN or SCC, the sensitivity was 0.804 and 0.902, the specificity 0.793 and 0.581, the positive predictive value 0.882 and 0.564, and the negative predictive value 0.678 and 0.908, respectively. Conclusion The ELS classification for NBI vascular changes of glottic lesions is a highly reliable tool whose systematic use allows a better diagnostic evaluation of suspicious laryngeal lesions, reliably distinguishing benign ones from those with a diagnosis of papillomatosis, SIN or SCC, thus paving the way towards confirmation of the optical biopsy concept.

scholarly journals Narrow Band Imaging with Magnification Can Pick Up Esophageal Squamous Cell Carcinoma More Efficiently Than Lugol Chromoendoscopy in Patients after Chemoradiotherapy

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Itsuko Asada-Hirayama ◽  
Shinya Kodashima ◽  
Mitsuhiro Fujishiro ◽  
Satoshi Ono ◽  
Keiko Niimi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Predictive Value ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Intraepithelial Neoplasia ◽  
Esophageal Neoplasia ◽  
Sensitivity Specificity

Aim. Little is known about the usefulness of narrow band imaging (NBI) for surveillance of patients after chemoradiotherapy for esophageal neoplasia. Its usefulness in detecting esophageal squamous cell carcinoma (SCC) or high-grade intraepithelial neoplasia (HGIN) in these patients was retrospectively compared to Lugol chromoendoscopy. Patients and Methods. We assessed the diagnostic ability of NBI with magnification based on the biopsy specimens obtained from iodine-unstained lesions. Seventy-two iodine-unstained lesions were biopsied and consecutively enrolled for this study. The lesions were divided into NBI positive and NBI negative. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of NBI with magnification and PPV of Lugol chromoendoscopy was calculated using histological assessment as a gold standard. Results. Forty-six endoscopic examinations using NBI with magnification followed by Lugol chromoendoscopy were performed to 28 patients. The prevalence of SCC and HGIN was 21.4%. Sensitivity, specificity, PPV, NPV, and accuracy of NBI were 100.0%, 98.5%, 85.7%, 100%, and 98.6%, respectively. On the contrary, PPV of Lugol chromoendoscopy were 8.3%. Compared to Lugol chromoendoscopy, NBI with magnification showed equal sensitivity and significantly higher PPV (). Conclusion. NBI with magnification would be able to pick up esophageal neoplasia more efficiently than Lugol chromoendoscopy in patients after chemoradiotherapy.

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