Long-term outcomes of locally or radically resected T1 colorectal cancer

Background and Aims: Endoscopic resection (ER) for submucosal invasive colorectal cancer (T1 CRC) can be grouped as curative ER (C-ER) and non-curative ER (NC-ER). Little is known about the long-term outcomes of patients in these two groups. Therefore, we have evaluated the long-term outcomes in endoscopically resected T1 CRC patients in C-ER and NC-ER groups. Methods: We conducted a retrospective study on 220 patients with T1 CRC treated with ER from January 2007 to December 2017. First, we investigated the long-term outcomes (5-year overall survival [OS] and recurrence-free survival [RFS]) in the C-ER group (n = 49). In the NC-ER group (n = 171), we compared long-term outcomes between patients who underwent additional surgical resection (ASR) (n = 117) and those who did not (surveillance-only, n = 54). Results: T1 CRC patients in the C-ER and NC-ER groups had a median follow-up of 44 (interquartile range 32–69) months. There was no risk of tumor recurrence and cancer-related deaths in patients with C-ER. In the NC-ER group, the 5-year OS rates were 75.3% and 92.6% in the surveillance-only and ASR subgroups, respectively. The hazard ratio (HR) for ASR in NC-ER vs. surveillance-only in NC-ER was statistically insignificant. However, RFS rates were significantly different between the ASR (97.2%) and surveillance-only (84.0%) subgroups. Multivariate analysis indicated a submucosal invasion depth (SID) of >2500 µm and margin positivity to be associated with recurrence. Conclusions: The surveillance-only approach can be considered as an alternative surgical option for T1 CRCs in selected patients undergoing NC-ER.

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Mo1677 LONG-TERM OUTCOMES OF ENDOSCOPIC RESECTION VERSUS SURGERY FOR T1 COLORECTAL CANCER: A SYSTEMATIC REVIEW AND META-ANALYSIS

Gastrointestinal Endoscopy ◽

10.1016/j.gie.2020.03.2871 ◽

2020 ◽

Vol 91 (6) ◽

pp. AB447

Author(s):

Jen-Hao Yeh ◽

Chih-Wen Lin ◽

Cheng-Hao Tseng ◽

Ching-Tai Lee ◽

Tsung-Chin Wu ◽

...

Keyword(s):

Colorectal Cancer ◽

Systematic Review ◽

Endoscopic Resection ◽

Meta Analysis ◽

Long Term Outcomes ◽

T1 Colorectal Cancer

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Exam 1: Long-term Outcomes of Primary Endoscopic Resection vs Surgery for T1 Colorectal Cancer: A Systematic Review and Meta-analysis

Clinical Gastroenterology and Hepatology ◽

10.1016/j.cgh.2020.09.024 ◽

2020 ◽

Vol 18 (12) ◽

pp. e148-e150

Keyword(s):

Colorectal Cancer ◽

Systematic Review ◽

Endoscopic Resection ◽

Meta Analysis ◽

Long Term Outcomes ◽

T1 Colorectal Cancer

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Short- and long-term outcomes of a self-expandable metallic stent versus a transanal decompression tube for pathological stage II and III left-sided obstructive colorectal cancer: a retrospective observational study

Surgery Today ◽

10.1007/s00595-021-02341-2 ◽

2021 ◽

Author(s):

Kentaro Sato ◽

Ken Imaizumi ◽

Hiroyuki Kasajima ◽

Michihiro Kurushima ◽

Minoru Umehara ◽

...

Keyword(s):

Colorectal Cancer ◽

Observational Study ◽

Metallic Stent ◽

Pathological Stage ◽

Long Term Outcomes ◽

Expandable Metallic Stent ◽

Transanal Decompression Tube ◽

Short And Long Term ◽

Decompression Tube

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Blood cell markers that can predict the long-term outcomes of patients with colorectal cancer

PLoS ONE ◽

10.1371/journal.pone.0220579 ◽

2019 ◽

Vol 14 (8) ◽

pp. e0220579 ◽

Cited By ~ 1

Author(s):

Hironori Mizuno ◽

Norihiro Yuasa ◽

Eiji Takeuchi ◽

Hideo Miyake ◽

Hidemasa Nagai ◽

...

Keyword(s):

Colorectal Cancer ◽

Blood Cell ◽

Long Term Outcomes ◽

Cell Markers

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Tu1689 - Long-Term Outcomes of Colorectal Cancer Patients with and without Malignant Large-Bowel Obstruction

Gastroenterology ◽

10.1016/s0016-5085(18)34425-1 ◽

2018 ◽

Vol 154 (6) ◽

pp. S-1352

Author(s):

Riku Yamamoto ◽

Shinya Munakata ◽

Tomoyuki Kushida ◽

Hajime Orita ◽

Mutsumi Sakurada ◽

...

Keyword(s):

Colorectal Cancer ◽

Cancer Patients ◽

Bowel Obstruction ◽

Large Bowel ◽

Large Bowel Obstruction ◽

Long Term Outcomes ◽

Colorectal Cancer Patients

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Comparison of Long-term outcomes between Lynch sydrome and sporadic colorectal cancer: a propensity score matching analysis

10.21203/rs.3.rs-130271/v1 ◽

2020 ◽

Author(s):

Yun Xu ◽

Cong Li ◽

Charlie Zhi-Lin Zheng ◽

Yu-Qin Zhang ◽

Tian-An Guo ◽

...

Keyword(s):

Colorectal Cancer ◽

Propensity Score ◽

Propensity Score Matching ◽

Control Group ◽

Sporadic Colorectal Cancer ◽

Long Term Outcomes ◽

Term Survival ◽

Long Term Survival ◽

Tumor Stages

Abstract Background Lynch syndrome (LS) is the most common hereditary colorectal cancer (CRC) syndrome. Comparison of prognosis between LS and sporadic CRC (SCRC) were rare,with conflicting results. This study aimed to compare the long-term outcomes between patients with LS and SCRC. Methods Between June 2008 and September 2018, a total of 47 patients were diagnosed with LS by genetic testing at Fudan University Shanghai Cancer Center. A 1:2 propensity score matching was performed to obtain homogeneous cohorts from SCRC group. Thereafter, 94 SCRC patients were enrolled as control group. The long-term survival rates between the two groups were compared, and the prognostic factors were also analyzed. Results The 5-year OS rate of LS group was 97.6%, which was significantly higher than of 82.6% for SCRC group (p = 0.029). The 5-year PFS rate showed no significant differences between the two groups (78.0% for LS group vs. 70.6% for SCRC patients; p = 0.262). The 5-year TFS rates in LS group was 62.1% for LS patients, which were significantly lower than of 70.6% for SCRC group (p = 0.039). By multivariate analysis, we found that tumor progression of primary CRC and TNM staging were independent risk factors for OS. Conclusion LS patients have better long-term survival prognosis than SCRC patients. Strict regular follow-up monitoring, detection at earlier tumor stages, and effective treatment are key to ensuring better long-term prognosis.

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