scholarly journals Long-Term Outcomes of T1 Colorectal Cancer after Endoscopic Resection

2020 ◽  
Vol 9 (8) ◽  
pp. 2451
Author(s):  
Eun Young Park ◽  
Dong Hoon Baek ◽  
Moon Won Lee ◽  
Gwang Ha Kim ◽  
Do Youn Park ◽  
...  

Background and Aims: Endoscopic resection (ER) for submucosal invasive colorectal cancer (T1 CRC) can be grouped as curative ER (C-ER) and non-curative ER (NC-ER). Little is known about the long-term outcomes of patients in these two groups. Therefore, we have evaluated the long-term outcomes in endoscopically resected T1 CRC patients in C-ER and NC-ER groups. Methods: We conducted a retrospective study on 220 patients with T1 CRC treated with ER from January 2007 to December 2017. First, we investigated the long-term outcomes (5-year overall survival [OS] and recurrence-free survival [RFS]) in the C-ER group (n = 49). In the NC-ER group (n = 171), we compared long-term outcomes between patients who underwent additional surgical resection (ASR) (n = 117) and those who did not (surveillance-only, n = 54). Results: T1 CRC patients in the C-ER and NC-ER groups had a median follow-up of 44 (interquartile range 32–69) months. There was no risk of tumor recurrence and cancer-related deaths in patients with C-ER. In the NC-ER group, the 5-year OS rates were 75.3% and 92.6% in the surveillance-only and ASR subgroups, respectively. The hazard ratio (HR) for ASR in NC-ER vs. surveillance-only in NC-ER was statistically insignificant. However, RFS rates were significantly different between the ASR (97.2%) and surveillance-only (84.0%) subgroups. Multivariate analysis indicated a submucosal invasion depth (SID) of >2500 µm and margin positivity to be associated with recurrence. Conclusions: The surveillance-only approach can be considered as an alternative surgical option for T1 CRCs in selected patients undergoing NC-ER.

2020 ◽  
Vol 18 (12) ◽  
pp. 2813-2823.e5 ◽  
Author(s):  
Jen-Hao Yeh ◽  
Cheng-Hao Tseng ◽  
Ru-Yi Huang ◽  
Chih-Wen Lin ◽  
Ching-Tai Lee ◽  
...  

2017 ◽  
Vol 85 (5) ◽  
pp. AB91-AB92
Author(s):  
Yara Backes ◽  
Wouter de Vos tot Nederveen Cappel ◽  
Jeroen van Bergeijk ◽  
Frank ter Borg ◽  
Matthijs P. Schwartz ◽  
...  

2020 ◽  
Vol 91 (6) ◽  
pp. AB447
Author(s):  
Jen-Hao Yeh ◽  
Chih-Wen Lin ◽  
Cheng-Hao Tseng ◽  
Ching-Tai Lee ◽  
Tsung-Chin Wu ◽  
...  

2021 ◽  
Vol 93 (6) ◽  
pp. AB86
Author(s):  
Hirohito Tanaka ◽  
Shiko Kuribayashi ◽  
Masanori Sekiguchi ◽  
Atsuo Iwamoto ◽  
Yoko Hachisu ◽  
...  

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
U Canpolat ◽  
D Kocyigit ◽  
M U Yalcin ◽  
C Coteli ◽  
Y Z Sener ◽  
...  

Abstract Background Currently available second-generation cryoballoon (CB2) is accepted as an effective and safe tool for pulmonary vein isolation (PVI). Although much more data exists about 1-year outcomes of CB2 ablation, data on long-term outcomes are scarce. Objective: We aimed to assess the long-term outcomes of PVI using CB2 in a large-scale symptomatic AF population at our tertiary referral center. Methods In this non-randomized prospective observational study, a total of 486 patients with paroxysmal (71%) or persistent (29%) AF who underwent index PVI using CB2 at our hospital between January 2013 and June 2017 were enrolled. Atrial tachyarrhythmia (ATa) free survival was defined as absence of AF, atrial flutter or atrial tachycardia recurrence >30 s following 3-months blanking period. Predictors of recurrence were evaluated by univariate and multivariate Cox proportional hazards regression models. Results Acute procedural success rate was 99.8% (1898/1902 PVs). Mean procedural and fluoroscopy time were 64.9±9.2 and 12.1±2.6, respectively. At median 39 (IQR: 26–56) months follow-up, ATa free survival was 78.6% after a single procedure (280/345 [81.2%] for paroxysmal AF vs 102/141 [72.3%] for persistent AF, p=0.019) and 84.4% after a mean 1.48±0.42 ablations.Cox regression analysis showed that left atrium diameter, duration of AF history and early ATa recurrence were found as the independent predictors of late recurrence. PNP was observed in 17 (3.5%) patients. Figure 1 Conclusions Second-generation CB based PVI is effective to maintain sinus rhythm in a significant proportion of paroxysmal and early persistent AF patients with an acceptable complication rates at long-term follow-up.


Endoscopy ◽  
2013 ◽  
Vol 45 (09) ◽  
pp. 718-724 ◽  
Author(s):  
Yusuke Yoda ◽  
Hiroaki Ikematsu ◽  
Takahisa Matsuda ◽  
Yuichiro Yamaguchi ◽  
Kinichi Hotta ◽  
...  

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