Blood cell markers that can predict the long-term outcomes of patients with colorectal cancer

Abstract Background Lynch syndrome (LS) is the most common hereditary colorectal cancer (CRC) syndrome. Comparison of prognosis between LS and sporadic CRC (SCRC) were rare,with conflicting results. This study aimed to compare the long-term outcomes between patients with LS and SCRC. Methods Between June 2008 and September 2018, a total of 47 patients were diagnosed with LS by genetic testing at Fudan University Shanghai Cancer Center. A 1:2 propensity score matching was performed to obtain homogeneous cohorts from SCRC group. Thereafter, 94 SCRC patients were enrolled as control group. The long-term survival rates between the two groups were compared, and the prognostic factors were also analyzed. Results The 5-year OS rate of LS group was 97.6%, which was significantly higher than of 82.6% for SCRC group (p = 0.029). The 5-year PFS rate showed no significant differences between the two groups (78.0% for LS group vs. 70.6% for SCRC patients; p = 0.262). The 5-year TFS rates in LS group was 62.1% for LS patients, which were significantly lower than of 70.6% for SCRC group (p = 0.039). By multivariate analysis, we found that tumor progression of primary CRC and TNM staging were independent risk factors for OS. Conclusion LS patients have better long-term survival prognosis than SCRC patients. Strict regular follow-up monitoring, detection at earlier tumor stages, and effective treatment are key to ensuring better long-term prognosis.

Download Full-text

More Favorable Short and Long-Term Outcomes for Screen-Detected Colorectal Cancer Patients

Frontiers in Oncology ◽

10.3389/fonc.2021.620644 ◽

2021 ◽

Vol 11 ◽

Author(s):

Gaya Spolverato ◽

Giulia Capelli ◽

Jessica Battagello ◽

Andrea Barina ◽

Susi Nordio ◽

...

Keyword(s):

Colorectal Cancer ◽

Disease Free Survival ◽

Target Population ◽

Proximal Colon ◽

Long Term Outcomes ◽

Curative Intent ◽

Diagnostic Modality ◽

Screening Programs ◽

Short And Long Term

BackgroundScreening significantly reduces mortality from colorectal cancer (CRC). Screen detected (SD) tumors associate with better prognosis, even at later stage, compared to non-screen detected (NSD) tumors. We aimed to evaluate the association between diagnostic modality (SD vs. NSD) and short- and long-term outcomes of patients undergoing surgery for CRC.Materials and MethodsThis retrospective cohort study involved patients aged 50–69 years, residing in Veneto, Italy, who underwent curative-intent surgery for CRC between 2006 and 2018. The clinical multi-institutional dataset was linked with the screening dataset in order to define diagnostic modality (SD vs. NSD). Short- and long-term outcomes were compared between the two groups.ResultsOf 1,360 patients included, 464 were SD (34.1%) and 896 NSD (65.9%). Patients with a SD CRC were more likely to have less comorbidities (p = 0.013), lower ASA score (p = 0.001), tumors located in the proximal colon (p = 0.0018) and earlier stage at diagnosis (p < 0.0001). NSD patients were found to have more aggressive disease at diagnosis, higher complication rate and higher readmission rate due to surgical complications (all p < 0.05). NSD patients had a significantly lower Disease Free Survival and Overall Survival (all p < 0.0001), even after adjusting by demographic, clinic-pathological, tumor, and treatment characteristics.ConclusionsSD tumors were associated with better long-term outcomes, even after multiple adjustments. Our results confirm the advantages for the target population to participate in the screening programs and comply with their therapeutic pathways.

Download Full-text

High World Heath Organization Performance Status Is Associated With Short And Long-term Outcomes After Colorectal Cancer Surgery

Diseases of the Colon & Rectum ◽

10.1097/dcr.0000000000001982 ◽

2021 ◽

Vol Publish Ahead of Print ◽

Author(s):

Rasmus Dahlin Bojesen ◽

Thea Helene Degett ◽

Susanne Oksbjerg Dalton ◽

Ismail Gögenur

Keyword(s):

Colorectal Cancer ◽

Performance Status ◽

Cancer Surgery ◽

Organization Performance ◽

Long Term Outcomes ◽

Colorectal Cancer Surgery ◽

Short And Long Term ◽

High World

Download Full-text

Long-term Outcomes of Surgery for Colorectal Cancer: A 20-Year Study

Journal of Surgical Research ◽

10.1016/j.jss.2018.09.026 ◽

2019 ◽

Vol 235 ◽

pp. 34-43 ◽

Cited By ~ 1

Author(s):

Patrick A. Walker ◽

Cameron Platell

Keyword(s):

Colorectal Cancer ◽

Long Term Outcomes

Download Full-text

A systematic review and meta-analysis comparing the short- and long-term outcomes for laparoscopic and open liver resections for liver metastases from colorectal cancer

Surgical Endoscopy ◽

10.1007/s00464-019-06774-2 ◽

2019 ◽

Vol 34 (1) ◽

pp. 349-360 ◽

Cited By ~ 9

Author(s):

Ruben Ciria ◽

Sira Ocaña ◽

Irene Gomez-Luque ◽

Federica Cipriani ◽

Mark Halls ◽

...

Keyword(s):

Colorectal Cancer ◽

Systematic Review ◽

Liver Metastases ◽

Meta Analysis ◽

Long Term Outcomes ◽

Liver Resections ◽

Short And Long Term

Download Full-text

Activity of Inflammatory Bowel Disease After Liver Transplantation for Primary Sclerosing Cholangitis Predicts Poorer Clinical Outcomes

Inflammatory Bowel Diseases ◽

10.1093/ibd/izz325 ◽

2020 ◽

Vol 26 (12) ◽

pp. 1901-1908 ◽

Cited By ~ 2

Author(s):

Matthew Peverelle ◽

Sarang Paleri ◽

Jed Hughes ◽

Peter De Cruz ◽

Paul J Gow

Keyword(s):

Colorectal Cancer ◽

Inflammatory Bowel Disease ◽

Liver Transplantation ◽

Bowel Disease ◽

Sclerosing Cholangitis ◽

High Grade ◽

Long Term Outcomes ◽

Inflammatory Bowel ◽

The Impact

Abstract Background The impact of inflammatory bowel disease (IBD) activity on long-term outcomes after liver transplantation (LT) for primary sclerosing cholangitis (PSC) is unknown. We examined the impact of post-LT IBD activity on clinically significant outcomes. Methods One hundred twelve patients undergoing LT for PSC from 2 centers were studied for a median of 7 years. Patients were divided into 3 groups according to their IBD activity after LT: no IBD, mild IBD, and moderate to severe IBD. Patients were classified as having moderate to severe IBD if they met at least 1 of 3 criteria: (i) Mayo 2 or 3 colitis or Simple Endoscopic Score–Crohn’s Disease ≥7 on endoscopy; (ii) acute flare of IBD necessitating steroid rescue therapy; or (iii) post-LT colectomy for medically refractory IBD. Results Moderate to severe IBD at any time post-transplant was associated with a higher risk of Clostridium difficile infection (27% vs 8% mild IBD vs 8% no IBD; P = 0.02), colorectal cancer/high-grade dysplasia (21% vs 3% both groups; P = 0.004), post-LT colectomy (33% vs 3% vs 0%) and rPSC (64% vs 18% vs 20%; P < 0.001). Multivariate analysis revealed that moderate to severe IBD increased the risk of both rPSC (relative risk [RR], 8.80; 95% confidence interval [CI], 2.81–27.59; P < 0.001) and colorectal cancer/high-grade dysplasia (RR, 10.45; 95% CI, 3.55–22.74; P < 0.001). Conclusions Moderate to severe IBD at any time post-LT is associated with a higher risk of rPSC and colorectal neoplasia compared with mild IBD and no IBD. Patients with no IBD and mild IBD have similar post-LT outcomes. Future prospective studies are needed to determine if more intensive treatment of moderate to severe IBD improves long-term outcomes in patients undergoing LT for PSC.

Download Full-text