Patient decision‐making in severe inflammatory bowel disease: the need for improved communication of treatment options and preferences

2019 ◽  
Vol 21 (12) ◽  
pp. 1406-1414 ◽  
Author(s):  
C. Lai ◽  
L. A. Sceats ◽  
W. Qiu ◽  
K. T. Park ◽  
A. M. Morris ◽  
...  
Keyword(s):  
Decision Making ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Treatment Options ◽  
Patient Decision Making ◽  
Patient Decision ◽  
Inflammatory Bowel

scholarly journals Inflammatory Bowel Disease and Pregnancy: Evidence, Uncertainty and Patient Decision-Making

2009 ◽  
Vol 23 (1) ◽  
pp. 49-53 ◽  
Author(s):  
Flavio M Habal ◽  
Varun Kapila
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Normal Pregnancy ◽  
Patient Decision Making ◽  
Medical Interventions ◽  
The Past ◽  
Patient Decision ◽  
Child Bearing ◽  
Inflammatory Bowel ◽  
Necrosis Factor

Inflammatory bowel disease (IBD) often affects women during their child-bearing years. Management of a pregnant IBD patient, or a patient contemplating pregnancy, poses unique challenges and can be quite daunting. Knowledge of the basic interplay among disease, normal host physiology and pregnancy is vital to managing these patients. One of the most important advances in the management of IBD over the past decade has been the finding that normal pregnancy outcomes can be achieved when a woman enters the pregnancy in remission. New insights into the safety of a wider spectrum of drugs in these patients has allowed for increased success in IBD management. The evidence supporting medical interventions including biological therapy such as antibodies to tumour necrosis factor agents is reviewed. Once the treating physician understands this complex relationship, management of the pregnant IBD patient can often become a rewarding experience.

scholarly journals Gastroenterologists’ Views of Shared Decision Making for Patients with Inflammatory Bowel Disease

2015 ◽  
Vol 60 (9) ◽  
pp. 2636-2645 ◽  
Author(s):  
Corey A. Siegel ◽  
Jennifer H. Lofland ◽  
Ahmad Naim ◽  
Jan Gollins ◽  
Danielle M. Walls ◽  
...  
Keyword(s):  
Decision Making ◽  
Inflammatory Bowel Disease ◽  
Shared Decision Making ◽  
Bowel Disease ◽  
Shared Decision ◽  
Inflammatory Bowel

scholarly journals Emerging roles of the Hedgehog signalling pathway in inflammatory bowel disease

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Zhuo Xie ◽  
Mudan Zhang ◽  
Gaoshi Zhou ◽  
Lihui Lin ◽  
Jing Han ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Molecular Mechanisms ◽  
Treatment Options ◽  
Critical Role ◽  
Signalling Pathway ◽  
Hedgehog Signalling Pathway ◽  
Inflammatory Bowel ◽  
Effective Drugs

AbstractThe Hedgehog (Hh) signalling pathway plays a critical role in the growth and patterning during embryonic development and maintenance of adult tissue homeostasis. Emerging data indicate that Hh signalling is implicated in the pathogenesis of inflammatory bowel disease (IBD). Current therapeutic treatments for IBD require optimisation, and novel effective drugs are warranted. Targeting the Hh signalling pathway may pave the way for successful IBD treatment. In this review, we introduce the molecular mechanisms underlying the Hh signalling pathway and its role in maintaining intestinal homeostasis. Then, we present interactions between the Hh signalling and other pathways involved in IBD and colitis-associated colorectal cancer (CAC), such as the Wnt and nuclear factor-kappa B (NF-κB) pathways. Furthermore, we summarise the latest research on Hh signalling associated with the occurrence and progression of IBD and CAC. Finally, we discuss the future directions for research on the role of Hh signalling in IBD pathogenesis and provide viewpoints on novel treatment options for IBD by targeting Hh signalling. An in-depth understanding of the complex role of Hh signalling in IBD pathogenesis will contribute to the development of new effective therapies for IBD patients.

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