S2k guideline: HPV-associated lesions of the external genital region and the anus - anogenital warts and precancerous lesions of the vulva, the penis, and the peri- and intra-anal skin (short version)

Penile intraepithelial neoplasia (PeIN) is currently classified in human papillomavirus (HPV)- and non-HPV-related subtypes with variable HPV genotypes. PeINs are frequently associated with other intraepithelial lesions in the same specimen. The aim of this study was to detect and compare HPV genotypes in PeINs and associated lesions using high-precision laser capture microdissection-polymerase chain reaction and p16INK4a immunostaining. We evaluated resected penile specimens from 8 patients and identified 33 PeINs and 54 associated lesions. The most common subtype was warty PeIN, followed by warty-basaloid and basaloid PeIN. Associated lesions were classical condylomas (17 cases), atypical classical condylomas (2 cases), flat condylomas (9 cases), atypical flat condylomas (6 cases), flat lesions with mild atypia (12 cases), and squamous hyperplasia (8 cases). After a comparison, identical HPV genotypes were found in PeIN and associated lesions in the majority of the patients (7 of 8 patients). HPV16 was the most common genotype present in both PeIN and corresponding associated lesion (50% of the patients). Nonspecific flat lesions with mild atypia, classical condylomas, and atypical condylomas were the type of associated lesions most commonly related to HPV16. Other high-risk HPV genotypes present in PeIN and associated nonspecific flat lesion with mild atypia were HPV35 and HPV39. In this study of HPV in the microenvironment of penile precancerous lesions, we identified identical high-risk HPV genotypes in PeIN and classical, flat, or atypical condylomas and, specially, in nonspecific flat lesions with mild atypia. It is possible that some of these lesions represent hitherto unrecognized precancerous lesions.

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General overview of gastrointestinal precancerous lesions, precursor lesions and associated lesions

European Journal of Cancer Prevention ◽

10.1097/00008469-199301001-00001 ◽

1993 ◽

Vol 2 (Supplement) ◽

pp. 1

Author(s):

B C Morson

Keyword(s):

Precancerous Lesions ◽

Precursor Lesions ◽

General Overview ◽

Associated Lesions

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How endoscopic findings may conceal gastric precancerous lesions? A study in a high-frequent area

European Journal of Cancer ◽

10.1016/s0959-8049(02)80066-1 ◽

2002 ◽

Vol 38 (11) ◽

pp. S51

Author(s):

J Mikaeli

Keyword(s):

Precancerous Lesions ◽

Endoscopic Findings

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Gliedmaßenapraxie bei Patienten mit Multipler Sklerose

Zeitschrift für Neuropsychologie ◽

10.1024/1016-264x/a000204 ◽

2017 ◽

Vol 28 (3-4) ◽

pp. 207-217

Author(s):

Kathi Maren Harscher ◽

Celina Hirth-Walther ◽

Ilka Buchmann ◽

Christian Dettmers ◽

Jennifer Randerath

Keyword(s):

Diagnostic Instrument ◽

Short Version ◽

Limb Apraxia

Zusammenfassung. Gliedmaßenapraxie ist eine Störung der motorischen Kognition, die besonders häufig nach linkshemisphärischem Schlaganfall auftritt. Diese Störung ist bei Patienten mit Multipler Sklerose (MS) noch wenig untersucht. Bisherige MS-Studien indizieren, dass die Leistung in den klassischen Pantomime- und Imitationstests beeinträchtigt sein kann. Die vorliegende Studie untersuchte die Gliedmaßenapraxie bei 26 MS-Patienten und 24 Gesunden mit dem Diagnostic Instrument for Limb Apraxia – Short Version (DILA-S), das zusätzlich zu den klassischen Imitations- und Pantomimetests auch den tatsächlichen Werkzeuggebrauch untersucht. Bei 27 % der MS-Patienten wurden apraktische Symptome in jeweils einzelnen Untertests diagnostiziert. Die Symptomausprägung war jedoch gering, sodass Gruppenvergleiche keine signifikanten Unterschiede zeigten. Insgesamt legen die Studienergebnisse nahe, dass Gliedmaßenapraxie bei MS-Patienten auftreten kann, aber vermutlich selten zu einem klinisch relevanten Symptom wird.

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Assessing Personality With Multi-Descriptor Items

European Journal of Psychological Assessment ◽

10.1027/1015-5759/a000368 ◽

2019 ◽

Vol 35 (1) ◽

pp. 117-125

Author(s):

Johannes Schult ◽

Rebecca Schneider ◽

Jörn R. Sparfeldt

Keyword(s):

University Students ◽

Construct Validity ◽

Big Five ◽

Reliability And Validity ◽

Personality Inventory ◽

The Other ◽

Short Version ◽

Big Five Inventory ◽

Personality Inventories

Abstract. The need for efficient personality inventories has led to the wide use of short instruments. The corresponding items often contain multiple, potentially conflicting descriptors within one item. In Study 1 ( N = 198 university students), the reliability and validity of the TIPI (Ten-Item Personality Inventory) was compared with the reliability and validity of a modified TIPI based on items that rephrased each two-descriptor item into two single-descriptor items. In Study 2 ( N = 268 university students), we administered the BFI-10 (Big Five Inventory short version) and a similarly modified version of the BFI-10 without two-descriptor items. In both studies, reliability and construct validity values occasionally improved for separated multi-descriptor items. The inventories with multi-descriptor items showed shortcomings in some factors of the TIPI and the BFI-10. However, the other scales worked comparably well in the original and modified inventories. The limitations of short personality inventories with multi-descriptor items are discussed.

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Following the Ants

European Journal of Psychological Assessment ◽

10.1027/1015-5759/a000299 ◽

2017 ◽

Vol 33 (6) ◽

pp. 409-421 ◽

Cited By ~ 10

Author(s):

Anne B. Janssen ◽

Martin Schultze ◽

Adrian Grötsch

Keyword(s):

Short Form ◽

Supervisor Support ◽

Proactive Personality ◽

Work Behavior ◽

Model Fit ◽

Item Selection ◽

Short Version ◽

Innovative Work Behavior ◽

Innovative Work ◽

Two Measures

Abstract. Employees’ innovative work is a facet of proactive work behavior that is of increasing interest to industrial and organizational psychologists. As proactive personality and supervisor support are key predictors of innovative work behavior, reliable, and valid employee ratings of these two constructs are crucial for organizations’ planning of personnel development measures. However, the time for assessments is often limited. The present study therefore aimed at constructing reliable short scales of two measures of proactive personality and supervisor support. For this purpose, we compared an innovative approach of item selection, namely Ant Colony Optimization (ACO; Leite, Huang, & Marcoulides, 2008 ) and classical item selection procedures. For proactive personality, the two item selection approaches provided similar results. Both five-item short forms showed a satisfactory reliability and a small, however negligible loss of criterion validity. For a two-dimensional supervisor support scale, ACO found a reliable and valid short form. Psychometric properties of the short version were in accordance with those of the parent form. A manual supervisor support short form revealed a rather poor model fit and a serious loss of validity. We discuss benefits and shortcomings of ACO compared to classical item selection approaches and recommendations for the application of ACO.

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