scholarly journals Brain metabolite biomarkers at term-equivalent age for early prediction of motor development at 2 years corrected age in very preterm infants

2018 ◽  
Vol 60 ◽  
pp. 20-21
Keyword(s):  
Preterm Infants ◽  
Motor Development ◽  
Early Prediction ◽  
Very Preterm Infants ◽  
Equivalent Age ◽  
Very Preterm ◽  
Brain Metabolite

scholarly journals Novel Diffuse White Matter Abnormality Biomarker at Term-Equivalent Age Enhances Prediction of Long-term Motor Development in Children Born Very Preterm

2020 ◽  
Author(s):  
Nehal A Parikh ◽  
Karen Harpster ◽  
Lili He ◽  
Venkata Sita Priyanka Illapani ◽  
Fatima Chughtai Khalid ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Gestational Age ◽  
Motor Development ◽  
Prognostic Biomarker ◽  
White Matter Abnormality ◽  
Very Preterm Infants ◽  
Equivalent Age ◽  
Very Preterm ◽  
Diffuse White Matter

Our objective was to evaluate the independent prognostic value of a novel MRI biomarker − objectively diagnosed diffuse white matter abnormality volume (DWMA; diffuse excessive high signal intensity) − for prediction of motor outcomes in very preterm infants. We prospectively enrolled a geographically-based cohort of very preterm infants without severe brain injury and born before 32 weeks gestational age. Structural brain MRI was obtained at term-equivalent age and DWMA volume was objectively quantified using a published validated algorithm. These results were compared with visually classified DWMA. We used multivariable linear regression to assess the value of DWMA volume, independent of known predictors, to predict motor development as assessed using the Bayley Scales of Infant & Toddler Development, Third Edition at 3 years of age. The mean (SD) gestational age of the cohort was 28.3 (2.4) weeks. In multivariable analyses, controlling for gestational age, sex, and abnormality on structural MRI, DWMA volume was an independent prognostic biomarker of Bayley Motor scores (β= −12.59 [95% CI: −18.70, −6.48] R2=0.41). Conversely, visually classified DWMA was not predictive of motor development. In conclusion, objectively quantified DWMA is an independent prognostic biomarker of long-term motor development in very preterm infants and warrants further study.

scholarly journals Novel diffuse white matter abnormality biomarker at term-equivalent age enhances prediction of long-term motor development in very preterm children

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Nehal A. Parikh ◽  
Karen Harpster ◽  
Lili He ◽  
Venkata Sita Priyanka Illapani ◽  
Fatima Chughtai Khalid ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Gestational Age ◽  
Motor Development ◽  
Prognostic Biomarker ◽  
White Matter Abnormality ◽  
Very Preterm Infants ◽  
Equivalent Age ◽  
Very Preterm ◽  
Diffuse White Matter

Abstract Our objective was to evaluate the independent prognostic value of a novel MRI biomarker—objectively diagnosed diffuse white matter abnormality volume (DWMA; diffuse excessive high signal intensity)—for prediction of motor outcomes in very preterm infants. We prospectively enrolled a geographically-based cohort of very preterm infants without severe brain injury and born before 32 weeks gestational age. Structural brain MRI was obtained at term-equivalent age and DWMA volume was objectively quantified using a published validated algorithm. These results were compared with visually classified DWMA. We used multivariable linear regression to assess the value of DWMA volume, independent of known predictors, to predict motor development as assessed using the Bayley Scales of Infant & Toddler Development, Third Edition at 3 years of age. The mean (SD) gestational age of the cohort was 28.3 (2.4) weeks. In multivariable analyses, controlling for gestational age, sex, and abnormality on structural MRI, DWMA volume was an independent prognostic biomarker of Bayley Motor scores ($$\beta $$ β = −12.59 [95% CI −18.70, −6.48] R2 = 0.41). Conversely, visually classified DWMA was not predictive of motor development. In conclusion, objectively quantified DWMA is an independent prognostic biomarker of long-term motor development in very preterm infants and warrants further study.

Early Electroencephalography Suppression and Postnatal Morbidities Correlate with Cerebral Volume at Term-Equivalent Age in Very Preterm Infants

Neonatology ◽  
2017 ◽  
Vol 113 (1) ◽  
pp. 15-20
Author(s):  
Sverre Wikström ◽  
Holger Hövel ◽  
Ingrid Hansen Pupp ◽  
Vineta Fellman ◽  
Petra S. Hüppi ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Very Preterm Infants ◽  
Equivalent Age ◽  
Very Preterm

scholarly journals Extremely Preterm Infants Have a Higher Fat Mass Percentage in Comparison to Very Preterm Infants at Term-Equivalent Age

2020 ◽  
Vol 8 ◽  
Author(s):  
Marlies Bruckner ◽  
Zahra Khan ◽  
Christoph Binder ◽  
Nicholas Morris ◽  
Bernadette Windisch ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Fat Mass ◽  
Mass Percentage ◽  
Very Preterm Infants ◽  
Equivalent Age ◽  
Very Preterm ◽  
Extremely Preterm ◽  
Extremely Preterm Infants

scholarly journals Routine Magnetic Resonance Imaging at Term-Equivalent Age Detects Brain Injury in 25% of a Contemporary Cohort of Very Preterm Infants

PLoS ONE ◽  
2017 ◽  
Vol 12 (1) ◽  
pp. e0169442 ◽  
Author(s):  
Vera Neubauer ◽  
Tanja Djurdjevic ◽  
Elke Griesmaier ◽  
Marlene Biermayr ◽  
Elke Ruth Gizewski ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Brain Injury ◽  
Magnetic Resonance ◽  
Preterm Infants ◽  
Resonance Imaging ◽  
Very Preterm Infants ◽  
Equivalent Age ◽  
Very Preterm ◽  
Routine Magnetic Resonance Imaging

scholarly journals Stereophotogrammetric head shape assessment in neonates is feasible and can identify distinct differences between term-born and very preterm infants at term equivalent age

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Petra Santander ◽  
Anja Quast ◽  
Johanna Hubbert ◽  
Laura Juenemann ◽  
Sebastian Horn ◽  
...  
Keyword(s):  
Body Weight ◽  
Preterm Infants ◽  
Total Duration ◽  
Neurodevelopmental Outcome ◽  
Small Sample ◽  
Head Shape ◽  
Term Infants ◽  
Very Preterm Infants ◽  
Equivalent Age ◽  
Very Preterm

AbstractThe development of head shape and volume may reflect neurodevelopmental outcome and therefore is of paramount importance in neonatal care. Here, we compare head morphology in 25 very preterm infants with a birth weight of below 1500 g and / or a gestational age (GA) before 32 completed weeks to 25 term infants with a GA of 37–42 weeks at term equivalent age (TEA) and identify possible risk factors for non-synostotic head shape deformities. For three-dimensional head assessments, a portable stereophotogrammetric device was used. The most common and distinct head shape deformity in preterm infants was dolichocephaly. Severity of dolichocephaly correlated with GA and body weight at TEA but not with other factors such as neonatal morbidity, sex or total duration of respiratory support. Head circumference (HC) and cranial volume (CV) were not significantly different between the preterm and term infant group. Digitally measured HC and the CV significantly correlated even in infants with head shape deformities. Our study shows that stereophotogrammetric head assessment is feasible in all preterm and term infants and provides valuable information on volumetry and comprehensive head shape characteristics. In a small sample of preterm infants, body weight at TEA was identified as a specific risk factor for the development of dolichocephaly.

scholarly journals Perinatal Risk and Protective Factors in the Development of Diffuse White Matter Abnormality on Term-Equivalent Age MRI in Infants Born Very Preterm

2020 ◽  
Author(s):  
Nehal A Parikh ◽  
Puneet Sharma ◽  
Lili He ◽  
Hailong Li ◽  
Mekibib Altaye ◽  
...  
Keyword(s):  
White Matter ◽  
Protective Factors ◽  
Preterm Infants ◽  
Brain Mri ◽  
White Matter Abnormality ◽  
Maternal Milk ◽  
Very Preterm Infants ◽  
Equivalent Age ◽  
Very Preterm ◽  
Diffuse White Matter

Importance: Diffuse white matter abnormality (DWMA) is the most common brain MRI finding in very preterm infants and is predictive of neurodevelopmental impairments. However, its etiology remains elusive and identifying perinatal risk and protective factors may allow clinicians to reduce the burden of DWMA. Objective: To identify perinatal clinical factors that are associated with the development of objectively diagnosed DWMA in very preterm infants. Design: A prospective cohort was enrolled between September 2016 and November 2019. Brain MRIs were collected at 39 to 45 weeks postmenstrual age (PMA) to evaluate DWMA volume. A pre-defined list of pertinent maternal characteristics, pregnancy/delivery data, and neonatal ICU data was collected for enrolled patients to identify antecedents of objectively diagnosed DWMA. Setting: Five level III/IV NICUs in the greater Cincinnati, Ohio area. Participants: A population-based sample of 392 very preterm infants born before 33 weeks gestational age. Exposure: Very preterm birth with associated diseases and treatments. Main Outcome and Measure: Objectively diagnosed DWMA volume on brain MRI at term-equivalent age. Results: 377 of the 392 very preterm infants (96%) had high quality MRI data. Mean (SD) gestational age was 29.3 (2.5) weeks. In multivariable linear regression analyses, pneumothorax (p=.027), severe bronchopulmonary dysplasia (BPD) (p=.009), severe retinopathy of prematurity (ROP) (p<0.001), and male sex (p=.041) were associated with increasing volume of DWMA. The following factors were associated with decreased risk of DWMA: dexamethasone for severe BPD (p=.004), duration of caffeine for severe BPD (p = 0.009), and exclusive maternal milk at NICU discharge (p=.049). Conclusions and Relevance: Severe ROP and BPD exhibited the strongest adverse association with the development of DWMA. Caffeine and dexamethasone treatments for infants with severe BPD exhibited a protective effect against development of DWMA. The beneficial association with maternal milk is also a modifiable factor that has clinical implications.

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