Introduction. Mathematical formulas, such as homeostatic model assessment
indexes, proved to be useful for the estimation of insulin resistance.
Nevertheless, numerous published results point to a considerable
variability of their reference values. The aim of this study was to use
homeostatic model assessment indexes and evaluate levels of insulin
resistance in nondiabetic patients. Material and Methods. The study
included 486 individuals (mean age 36.84 ? 12.86; 17% of males and 83% of
females). Blood sampling was performed in order to determine glucose and
insulin plasma levels, at the 0th and 120th minute of the oral glucose
tolerance test. The indexes were calculated by the use of homeostatic model
assessment 2 calculator, homeostatic model assessment of insulin resistance,
homeostatic model assessment of insulin sensitivity, and homeostatic model
assessment of ?-cells function. The results were statistically analyzed
using a Data Analysis programme. Results. In the examined population, the
average glycemic values of the oral glucose tolerance test were within the
euglycemic scope (Gluc 0 = 4.76 ? 0.45 mmol/L; Gluc 120 = 5.24 ? 1.17
mmol/L), while the average values of calculated homeostatic model
assessment indexes were: insulin resistance - 1.41 ? 0.82; ?-cells function
- 131.54 ? 49.41%, and insulin sensitivity - 91.94 ? 47.32%. According to
study cut-off values, homeostatic model assessment of insulin resistance
was less than 2. We found 84 (17.28%) individuals with increased insulin
resistance. Also, we set the lowest reference value for homeostatic model
assessment of insulin sensitivity at less than 50%. With the probability
of 66.67% (x? ? 1SD), basal insulin level under 11.9 mIU/L can be considered
to correspond to physiologic level of insulin resistance. Conclusion. The
follow-up of increased insulin resistance and altered secretion of
pancreatic ?-cells, at early stages of glucose regulation disturbances, may
be useful in assessing dynamics and level of glucose regulation disturbances
and their appropriate treatment. <br><br><font color="red"><b> This article has been corrected. Link to the correction <u><a href="http://dx.doi.org/10.2298/MPNS1708202E">10.2298/MPNS1708202E</a><u></b></font>