<b>Objective </b>To estimate
risk of fracture in men and women with recent diagnosis of type 2 diabetes
compared to individuals without diabetes.
<p><b>Research Design and Methods<strong> </strong></b>In this cohort
study we used routinely-collected UK primary care data from The Health
Improvement Network. In adults (>35 years) diagnosed with type 2 diabetes between
2004-2013 fractures sustained until 2019 were identified and compared to fractures
sustained in individuals without diabetes. Multivariable models estimated time
to first fracture following diagnosis of diabetes. Annual prevalence rates included at least one fracture in a given year. <strong></strong></p>
<p><strong>Results </strong>Among
174,244 individuals with incident type 2 diabetes and 747,290 without diabetes,
there was no increased risk of fracture among males with diabetes (adjusted
hazards ratio (aHR) 0.97 (95%CI 0.94, 1.00)) and a small reduced risk among
females (aHR 0.94, (95%CI 0.92, 0.96)). In those aged
85 years and over those in the diabetes cohort were at significantly lower risk
of incident fracture (Males: aHR 0.85, 95%CI
0.71, 1.00; Females: aHR 0.85, 95%CI 0.78, 0.94). For those in the most
deprived areas, aHRs were 0.90 (95%CI 0.83, 0.98) for males and 0.91 (95%CI
0.85, 0.97) for females. Annual fracture prevalence rates, by sex, were similar
for those with and without type 2 diabetes.</p>
<p><strong>Conclusion We
found </strong>no evidence to suggest a higher risk
of fracture following diagnosis of type 2 diabetes. After a diagnosis of type 2
diabetes individuals should be encouraged to make positive lifestyle changes,
including undertaking weight-bearing physical activities that improve bone
health.</p>
Cardiovascular Risk Factor Burden in People With Incident Type 2 Diabetes in the U.S. Receiving Antidiabetic and Cardioprotective Therapies
