Potential role of
            anti‐
            interleukin‐17 in
            COVID
            ‐19 treatment

With 7.6 million deaths globally, cancer according to the World Health Organisation is still one of the leading causes of death worldwide. Interleukin 17 (IL-17) is a cytokine produced by Th17 cells, a T helper cell subset developed from an activated CD4+ T-cell. Whilst the importance of IL-17 in human autoimmune disease, inflammation, and pathogen defence reactions has already been established, its potential role in cancer progression still needs to be updated. Interestingly studies have demonstrated that IL-17 plays an intricate role in the pathophysiology of cancer, from tumorigenesis, proliferation, angiogenesis, and metastasis, to adapting the tumour in its ability to confer upon itself both immune, and chemotherapy resistance. This review will look into IL-17 and summarise the current information and data on its role in the pathophysiology of cancer as well as its potential application in the overall management of the disease.

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Acinetobacter baumanniiInfection and IL-17 Mediated Immunity

Mediators of Inflammation ◽

10.1155/2016/9834020 ◽

2016 ◽

Vol 2016 ◽

pp. 1-5 ◽

Cited By ~ 5

Author(s):

Zihe Yan ◽

Junjun Yang ◽

Renjing Hu ◽

Xichi Hu ◽

Kong Chen

Keyword(s):

Immune Response ◽

Acinetobacter Baumannii ◽

Military Personnel ◽

Potential Role ◽

Multidrug Resistant ◽

Interleukin 17 ◽

Hospital Acquired Infections ◽

Host Pathogen Interaction ◽

Hospital Acquired

Acinetobacter baumanniiis a significant cause of severe hospital-acquired infections with a recent rise in multidrug-resistant infections involving traumatic wounds of military personnel. The interleukin-17 (IL-17) pathway is essential for neutrophil recruitment in response to a variety of pathogens, while the control ofA. baumanniiinfection is known to be dependent on neutrophils. This suggests that IL-17 may play an important role inA. baumanniiinfection; however, this has yet to be studied. Here, we summarize the recent advances in understanding the host-pathogen interaction ofA. baumanniiand propose a potential role of the IL-17 pathway in generating a protective immune response.

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Overexpression of Interleukin-23 and Interleukin-17 in the Lesion of Pemphigus Vulgaris: A Preliminary Study

Mediators of Inflammation ◽

10.1155/2014/463928 ◽

2014 ◽

Vol 2014 ◽

pp. 1-5 ◽

Cited By ~ 15

Author(s):

Jixin Xue ◽

Wenting Su ◽

Zhiwei Chen ◽

Youhui Ke ◽

Xiaojing Du ◽

...

Keyword(s):

Potential Role ◽

Pemphigus Vulgaris ◽

Pemphigus Foliaceus ◽

Interleukin 17 ◽

Healthy Individuals ◽

Pathogenetic Role ◽

Biopsy Specimens ◽

Preliminary Study ◽

Interleukin 23

IL-23/IL-17 axis has been identified as major factor involved in the pathogenesis of several autoimmune diseases; yet its pathogenetic role in pemphigus vulgaris (PV) remains controversial. The aim of this research was to investigate the potential role of IL-23/IL-17 axis in the immunopathogenesis of PV, and correlation between IL-23+ cells and IL-17+ cells was also evaluated. For this purpose, ten patients with PV, three patients with pemphigus foliaceus (PF), and six healthy individuals were allocated to this research. The lesional skin biopsy specimens were obtained before treatment. Then immunofluorescence staining was performed to analyze the expression of IL-23 and IL-17 in the PV/PF patients and the healthy individuals. The results showed that the numbers of IL-23+ and IL-17+ cells were significantly higher in PV lesions, compared to PF lesions and normal control skins, respectively (allP<0.05). Moreover, the correlation between IL-23+ cells and IL-17+ cells was significant (r=0.7546;P<0.05). Taken together, our results provided evidence that the IL-23/IL-17 axis may play a crucial role in the immunopathogenesis of PV and may serve as novel therapeutic target for PV.

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The potential role of interleukin-17 in the immunopathology of periodontal disease

Journal Of Clinical Periodontology ◽

10.1111/j.1600-051x.2005.00676.x ◽

2005 ◽

Vol 32 (4) ◽

pp. 369-374 ◽

Cited By ~ 119

Author(s):

Keiso Takahashi ◽

Takashi Azuma ◽

Hitoshi Motohira ◽

D. F. Kinane ◽

Shin Kitetsu

Keyword(s):

Periodontal Disease ◽

Potential Role ◽

Interleukin 17

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POPDC proteins and cardiac function

Biochemical Society Transactions ◽

10.1042/bst20190249 ◽

2019 ◽

Vol 47 (5) ◽

pp. 1393-1404 ◽

Cited By ~ 4

Author(s):

Thomas Brand

Keyword(s):

Potential Role ◽

Striated Muscle ◽

Short Review ◽

Effector Proteins ◽

Muscle Disease ◽

Disease Genes ◽

Protein Protein Interaction ◽

Interaction Partners ◽

And Function

Abstract The Popeye domain-containing gene family encodes a novel class of cAMP effector proteins in striated muscle tissue. In this short review, we first introduce the protein family and discuss their structure and function with an emphasis on their role in cyclic AMP signalling. Another focus of this review is the recently discovered role of POPDC genes as striated muscle disease genes, which have been associated with cardiac arrhythmia and muscular dystrophy. The pathological phenotypes observed in patients will be compared with phenotypes present in null and knockin mutations in zebrafish and mouse. A number of protein–protein interaction partners have been discovered and the potential role of POPDC proteins to control the subcellular localization and function of these interacting proteins will be discussed. Finally, we outline several areas, where research is urgently needed.

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