scholarly journals Cardiotoxicity in breast cancer treatment: What about left ventricular diastolic function and left atrial function?

2019 ◽  
Vol 36 (10) ◽  
pp. 1806-1813 ◽  
Author(s):  
Ana Teresa Timóteo ◽  
Luisa Moura Branco ◽  
Frederico Filipe ◽  
Ana Galrinho ◽  
Pedro Rio ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Treatment ◽  
Diastolic Function ◽  
Left Atrial ◽  
Left Ventricular Diastolic Function ◽  
Breast Cancer Treatment ◽  
Left Ventricular ◽  
Atrial Function ◽  
Left Atrial Function ◽  
Ventricular Diastolic Function

scholarly journals P594Contrast transthoracic echocardiography as a gatekeeper for patent foramen ovale closureP595Mitral annular displacement in apical four-chamber view by speckle-tracking echocardiography as a simple index for left ventricular longitudinal systolic functionP596Impact of chronic glycemic control on left ventricular myocardial function in young patients with type 1 diabetes mellitusP597Association of left atrial function echocardiographic parametres with fibrosis assesed invasively in patients with sinus rhythm and atrial fibrillation undergoing ablation for atrial fibrillationP598Mitral annular calcification decreases diastolic tissue Doppler velocity(E') in regions affected with calcificationsP5992D longitudinal LV speckle tracking strain pattern in breast cancer survivors: sports activity vs exercise as prescription modelP600Catheter related atrial fibrillation is associated with left atrial deformation in patients with paroxsymal supraventricular tachycardia: a study of two-dimensional speckle tracking echocardiographyP601Early radiotherapy-induced ecg changes and their comparison with echocardiography in breast cancer patientsP602Renal function is a major determinant of decreased sub-epicardial longitudinal strain in hypertensionP603Evaluation of left atrial function in patients with non valvular atrial fibrillation post cardioversion: speckle tracking echocardiographyP604Myocardial dysfunction in ANCA vasculitis measured by two-dimensional speckle tracking echocardiographyP605CRT, arterial stiffness and ventricular-arterial coupling in HFrEFP606Mitral annular morphology and function in cardiac amyloidosis as assessed by three-dimensional speckle tracking echocardiographyP607Coronary plaque characterization in Egyptian metabolic syndrome patients using 64-MDCT

2016 ◽  
Vol 17 (suppl 2) ◽  
pp. ii109-ii113 ◽  
Author(s):  
M. Muratori ◽  
T. Hozumi ◽  
C. Ruisanchez Villar ◽  
E. Pilichowska ◽  
L. Chebrolu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Atrial Fibrillation ◽  
Left Atrial ◽  
Speckle Tracking ◽  
Young Patients ◽  
Left Ventricular ◽  
Atrial Function ◽  
Left Atrial Function ◽  
Doppler Velocity ◽  
Two Dimensional

277 Temporal trends of advanced 2D-speckle tracking echocardiography in trastuzumab treated patients

2021 ◽  
Vol 23 (Supplement_G) ◽  
Author(s):  
Paolo Springhetti ◽  
Corinna Bergamini ◽  
Lorenzo Niro ◽  
Luisa Ferri ◽  
Giovanni Benfari ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Left Atrial ◽  
Speckle Tracking ◽  
Left Ventricular ◽  
Atrial Function ◽  
Left Atrial Function ◽  
2D Speckle Tracking ◽  
Her 2 ◽  
Positive Breast Cancer

Abstract Aims Trastuzumab (TZ) is widely used for his key role in HER2 positive breast cancer. However, it may have different side effects on the cardiovascular system. One of the most concerning complication is cardiotoxicity. Many studies have highlighted the importance of the screening for subclinical myocardial dysfunction using left ventricular ejection fraction (LVEF) and global longitudinal strain (GLS). However, there are few studies investigating the left atrial function in relation to the development of early cardiac damage. Aim of this study is to analyse the modification of GLS and PALS in patients undergoing therapy with TZ in a follow-up period of 12 months. The eventual fluctuation of left atrial function under chemotherapy was evaluated and the correlation between subclinical atrial disfunction and early left ventricular impairment was searched. Methods One hundred and five women affected by non-metastatic HER-2 positive breast cancer treated with TZ were enrolled. Each patient underwent a complete echocardiography every 3 months, for a total of five exams pro patient. Thirty-seven patients (35%) were excluded from the left atrial function analysis while LV function evaluation was performed in 83 patients (21%). Exclusion criteria were poor quality imaging and lack of a complete Follow-up with consequent missing data. 2D-Speckle tracking analysis was performed at baseline and at each examination using Tomtec software in order to analyse both atrial and left ventricular function. Subclinical LV disfunction was defined as a GLS reduction of ≥ 15% compared to the baseline value. Left atrial impairment was arbitrary defined as a PALS reduction of ≥ 25% compared to the initial value. Finally, trends of GLS and PALS during 12 months-Follow-up periods were analysed. Results A total of 48.9% patients developed subclinical LV dysfunction. Similarly, 48.3% patients showed a left atrial impairment. Interestingly a significant (P = 0.0001) reduction in GLS was observed during the follow-up, particularly in the first 6 months of treatment. PALS showed a similar trend with a significant decrease during the whole 12 months-follow-up (P = 0.0001) and mostly in the first 6 months. Only 11% patients showed a significant reduction of LVEF defined as an absolute reduction of LVEF >10% from baseline. Conclusions In HER 2 positive breast cancer patients treated with Trastuzumab development of left atrial impairment in not uncommon and PALS modifications follow a similar pattern to GLS variations during the treatment course, suggesting a possible cardiotoxic effect of such therapy on both atrial and left ventricular myocardium and physiology. However, the potential role of an early atrial impairment detection in predicting subsequent cardiotoxicity in terms of significant LVEF reduction still needs to be tested with further studies.

scholarly journals Echocardiographic Evaluation of Left Atrial Mechanics: Function, History, Novel Techniques, Advantages, and Pitfalls

2015 ◽  
Vol 2015 ◽  
pp. 1-12 ◽  
Author(s):  
Roman Leischik ◽  
Henning Littwitz ◽  
Birgit Dworrak ◽  
Pankaj Garg ◽  
Meihua Zhu ◽  
...  
Keyword(s):  
Diastolic Function ◽  
Left Atrial ◽  
Left Ventricular Diastolic Function ◽  
Tissue Doppler ◽  
Left Ventricular ◽  
Doppler Imaging ◽  
Current Standard ◽  
Ventricular Diastolic Function ◽  
Strain Rate Imaging ◽  
Strain And Strain Rate

Left atrial (LA) functional analysis has an established role in assessing left ventricular diastolic function. The current standard echocardiographic parameters used to study left ventricular diastolic function include pulsed-wave Doppler mitral inflow analysis, tissue Doppler imaging measurements, and LA dimension estimation. However, the above-mentioned parameters do not directly quantify LA performance. Deformation studies using strain and strain-rate imaging to assess LA function were validated in previous research, but this technique is not currently used in routine clinical practice. This review discusses the history, importance, and pitfalls of strain technology for the analysis of LA mechanics.

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