Sex‐specific changes in peripheral metabolism in a model of chronic anxiety induced by prenatal stress

2021 ◽  
Author(s):  
Ana Sofia Ferreira ◽  
Sofia Galvão ◽  
Rita Gaspar ◽  
Ana C. Rodrigues‐Neves ◽  
António F. Ambrósio ◽  
...  
Keyword(s):  
Prenatal Stress ◽  
Chronic Anxiety ◽  
Peripheral Metabolism

scholarly journals Sex-specific effects of prenatal stress on glucose homoeostasis and peripheral metabolism in rats

2013 ◽  
Vol 217 (2) ◽  
pp. 161-173 ◽  
Author(s):  
Paula J Brunton ◽  
Katie M Sullivan ◽  
David Kerrigan ◽  
John A Russell ◽  
Jonathan R Seckl ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Prenatal Stress ◽  
Social Stress ◽  
Subcutaneous Fat ◽  
Oral Glucose ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Glucose Homoeostasis ◽  
Peripheral Metabolism

Glucocorticoid overexposure during pregnancy programmes offspring physiology and predisposes to later disease. However, any impact of ethologically relevant maternal stress is less clear, yet of physiological importance. Here, we investigated in rats the short- and long-term effects in adult offspring of repeated social stress (exposure to an aggressive lactating female) during late pregnancy on glucose regulation following stress, glucose–insulin homoeostasis and peripheral expression of genes important in regulating glucose and lipid metabolism and glucocorticoid action. Prenatal stress (PNS) was associated with reduced birth weight in female, but not male, offspring. The increase in blood glucose with restraint was exaggerated in adult PNS males compared with controls, but not in females. Oral glucose tolerance testing showed no effects on plasma glucose or insulin concentrations in either sex at 3 months; however, at 6 months, PNS females were hyperinsulinaemic following an oral glucose load. In PNS males, plasma triglyceride concentrations were increased, with reduced hepatic mRNA expression of 5α-reductase and peroxisome proliferator-activated receptor α (Pparα(Ppara)) and a strong trend towards reduced peroxisome proliferator-activated receptor gamma coactivator 1α (Pgc1α(Ppargc1a)) andPparγ(Pparg) expression, whereas onlyPgc1αmRNA was affected in PNS females. Conversely, in subcutaneous fat, PNS reduced mRNA expression of 11β-hydroxysteroid dehydrogenase type 1 (11βhsd1), phosphoenolpyruvate carboxykinase (Pepck(Pck1)), adipose triglyceride lipase (Atgl) and diglyceride acyltransferase 2 (Dgat2) in females, but onlyPepckmRNA expression was reduced in PNS males. Thus, prenatal social stress differentially programmes glucose homoeostasis and peripheral metabolism in male and female offspring. These long-term alterations in physiology may increase susceptibility to metabolic disease.

Fine Structural Alterations in Thyroid Follicular Cells (FC) and Changes in Serum Thyroxine Produced by Feeding Polychlorinated Biphenyl (PCB) to Rats

1977 ◽  
Vol 35 ◽  
pp. 498-499
Author(s):  
W.T. Collins ◽  
Charles C. Capen ◽  
Louis Kasza
Keyword(s):  
Feed Efficiency ◽  
Polychlorinated Biphenyl ◽  
Serum Proteins ◽  
Skin Lesions ◽  
Hepatic Necrosis ◽  
Ultrastructural Changes ◽  
Lymphoid Tissues ◽  
Heat Transfer Fluids ◽  
Thyroid Follicular Cells ◽  
Peripheral Metabolism

The widespread contamination of the environment with PCB, a compound used extensively by industry in hydraulic and heat transfer fluids as well as plasticizers and solvents in adhesives and sealants, has resulted in detectable tissue levels in a large portion of the human population, domestic animals, and wildlife. Intoxication with PCB produces severe hepatic necrosis, degeneration of lymphoid tissues and kidney, skin lesions, decreased reproductive performance, reduced feed efficiency, and decreased weight gain. PCB also has been reported to reduce the binding of thyroid hormone to serum proteins and enhance the peripheral metabolism of thyroxine with increased excretion of thyroxine-glucuronide in the bile (Bastomsky, Endocrinology 95: 1150-1155, 1974).The objectives of this investigation were (1) to investigate the histopathologic, histochemical, and ultrastructural changes in thyroid FC produced by the acute (4 week) and chronic (12 week) administration of low (50 ppm) and high (500 ppm) doses of PCB to rats, (2) to correlate these alterations to changes in serum immunoreactive thyroxine concentration, and (3) to investigate the persistence of the effects of PCB on the thyroid gland.

Preconditioning to prenatal stress has different behavioral consequences during postnatal ontogenesis

2012 ◽  
Author(s):  
N. M. Dubrovskaya ◽  
D. S. Vasilev ◽  
N. L. Tumanova ◽  
N. N. Nalivaeva ◽  
O. S. Alexeeva ◽  
...  
Keyword(s):  
Prenatal Stress ◽  
Postnatal Ontogenesis ◽  
Behavioral Consequences

Chronic anxiety in the elderly

1998 ◽  
Keyword(s):  
The Elderly ◽  
Chronic Anxiety

METABOLISM AND MODE OF ACTION OF ANDROGENS IN TARGET TISSUES OF MALE RATS

1972 ◽  
Vol 69 (1) ◽  
pp. 165-173 ◽  
Author(s):  
H. Schmidt ◽  
I. Noack ◽  
K. D. Voigt
Keyword(s):  
Cell Proliferation ◽  
Cell Metabolism ◽  
Seminal Vesicles ◽  
Male Rats ◽  
Ventral Prostate ◽  
Nucleic Acid Content ◽  
The Difference ◽  
Independent Effects ◽  
Sites Of Action ◽  
Peripheral Metabolism

ABSTRACT The effect of testosterone and 5α-dihydrotestosterone on protein and nucleic acid content as well as on the activities of some enzymes has been studied in the ventral prostate and the seminal vesicles of immature castrated rats. Both androgens were given intraperitoneally in doses of 1 mg daily for one or three days the rats were sacrificed one day after the last injection. In the prostate it was found that 5α-dihydrotestosterone had a greater effect on DNA increase, i. e. cell proliferation than testosterone, whereas cell metabolism was stimulated by the two androgens to nearly the same extent. In the seminal vesicles a single dose led to the same results as had been obtained in the prostate, i. e. a greater cell proliferative action of 5α-dihydrotestosterone and an equal stimulation of cell metabolism by testosterone and 5α-dihydrotestosterone was also observed. When three doses of the two androgens were given, cell proliferation as well as cell metabolism in the seminal vesicles were significantly more increased after 5α-dihydrotestosterone than after testosterone. The difference of action after systemic administration of the two androgens is explained by their different accumulation and by their different peripheral metabolism in the target tissues. From the partly independent effects of various androgens on cell proliferation and cell metabolism the conclusion may be drawn that there exist at least two intracellular sites of action.

Chronic Anxiety In A Congregation: A Systems Approach

1995 ◽  
Author(s):  
Harris H. SCHULTZ
Keyword(s):  
Systems Approach ◽  
Chronic Anxiety

Prenatal Stress as a Factor of the Development of Addictive States

2020 ◽  
Vol 56 (6) ◽  
pp. 471-490
Author(s):  
V. A. Stratilov ◽  
E. I. Tyulkova ◽  
O. V. Vetrovoy
Keyword(s):  
Prenatal Stress

Rapid and Prolonged Antidepressant-like Effect of Crocin Is Associated with GHSR-Mediated Hippocampal Plasticity-related Proteins in Mice Exposed to Prenatal Stress

2020 ◽  
Vol 11 (8) ◽  
pp. 1159-1170 ◽  
Author(s):  
Ruyan Wu ◽  
Dong Xiao ◽  
Xin Shan ◽  
Yu Dong ◽  
Wei-Wei Tao
Keyword(s):  
Prenatal Stress ◽  
Hippocampal Plasticity ◽  
Related Proteins
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