Exogenous hydrogen sulphide supplement accelerates skin wound healing via oxidative stress inhibition and vascular endothelial growth factor enhancement

2019 ◽  
Vol 28 (7) ◽  
pp. 776-785 ◽  
Author(s):  
Mengting Xu ◽  
Yuyun Hua ◽  
Yan Qi ◽  
Guoliang Meng ◽  
Shengju Yang
Keyword(s):  
Oxidative Stress ◽  
Vascular Endothelial Growth Factor ◽  
Wound Healing ◽  
Growth Factor ◽  
Hydrogen Sulphide ◽  
Skin Wound ◽  
Vascular Endothelial ◽  
Skin Wound Healing ◽  
Endothelial Growth Factor

scholarly journals Wound Healing Effect of Gintonin Involves Lysophosphatidic Acid Receptor/Vascular Endothelial Growth Factor Signaling Pathway in Keratinocytes

2021 ◽  
Vol 22 (18) ◽  
pp. 10155
Author(s):  
Sun-Hye Choi ◽  
Kyung-Jong Won ◽  
Rami Lee ◽  
Han-Sung Cho ◽  
Sung-Hee Hwang ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Wound Healing ◽  
Lysophosphatidic Acid ◽  
Skin Wound ◽  
Vascular Endothelial ◽  
Hacat Cells ◽  
Skin Wound Healing ◽  
Lpa Receptor ◽  
Endothelial Growth Factor

Gintonin, a novel compound of ginseng, is a ligand of the lysophosphatidic acid (LPA) receptor. The in vitro and in vivo skin wound healing effects of gintonin remain unknown. Therefore, the objective of this study was to investigate the effects of gintonin on wound healing-linked responses, especially migration and proliferation, in skin keratinocytes HaCaT. In this study, 2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide assay, Boyden chamber migration assay, scratch wound healing assay, and Western blot assay were performed. A tail wound mouse model was used for the in vivo test. Gintonin increased proliferation, migration, and scratch closure in HaCaT cells. It also increased the release of vascular endothelial growth factor (VEGF) in HaCaT cells. However, these increases, induced by gintonin, were markedly blocked by treatment with Ki16425, an LPA inhibitor, PD98059, an ERK inhibitor, 1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid tetrakis (acetoxymethyl ester), a calcium chelator, and U73122, a PLC inhibitor. The VEGF receptor inhibitor axitinib also attenuated gintonin-enhanced HaCaT cell proliferation. Gintonin increased the phosphorylation of AKT and ERK1/2 in HaCaT cells. In addition, gintonin improved tail wound healing in mice. These results indicate that gintonin may promote wound healing through LPA receptor activation and/or VEGF release-mediated downstream signaling pathways. Thus, gintonin could be a beneficial substance to facilitate skin wound healing.

scholarly journals Angelica dahurica and Rheum officinale Facilitated Diabetic Wound Healing by Elevating Vascular Endothelial Growth Factor

2021 ◽  
pp. 1-19
Author(s):  
Yuh-Huey Chao ◽  
Wan-Ting Yang ◽  
Ming-Chang Li ◽  
Fwu-Lin Yang ◽  
Ru-Ping Lee
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Wound Healing ◽  
Growth Factor ◽  
Smooth Muscle Actin ◽  
Intraperitoneal Administration ◽  
Angelica Dahurica ◽  
Vascular Endothelial ◽  
Sprague Dawley ◽  
Diabetic Wounds ◽  
Endothelial Growth Factor

Traditional Chinese medicine (TCM) provides alternative treatment choices for diabetic wounds. The aim of this study was to evaluate the effects of Angelica dahurica and Rheum officinale (ARE) on diabetic wounds and its underlying action mechanism. A total of 36 healthy male Sprague–Dawley rats were randomly divided into three groups: diabetes mellitus (DM) rats treated with ARE (DM-ARE), DM rats treated with 0.9% saline (DM-NS), and non-DM rats treated with 0.9% saline (NDM-NS). DM was induced by intraperitoneal administration of 40 mg/kg of streptozotocin after a 2-week high-fat diet feeding. After excisional skin wounds and treatments, the remaining wound area (RWA) in each group was measured. The RWA in the DM-NS group (69.60% ± 2.35%) was greater than that in the DM-ARE (55.70% ± 1.85%) and NDM-NS groups (52.50% ± 2.77%) on day 6. Besides, the DM-ARE group showed higher vascular endothelial growth factor (VEGF), higher inducible nitric oxide synthase (iNOs), higher [Formula: see text]-smooth muscle actin ([Formula: see text]-SMA), and lower nuclear factor kappa-light-chain-enhancer of activated B cell (NF-[Formula: see text]B) expression in the wound skin tissue. These results showed that treatment with ARE shifted the recovery pattern of diabetic rats to the pattern of nondiabetic rats, indicating that ARE may improve wound healing in diabetic conditions.

Hypertension During Vascular Endothelial Growth Factor Inhibition: Focus on Nitric Oxide, Endothelin-1, and Oxidative Stress

2014 ◽  
Vol 20 (1) ◽  
pp. 135-145 ◽  
Author(s):  
Stephanie Lankhorst ◽  
Mariëtte H.W. Kappers ◽  
Joep H.M. van Esch ◽  
A.H. Jan Danser ◽  
Anton H. van den Meiracker
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Vascular Endothelial ◽  
Endothelin 1 ◽  
Endothelial Growth Factor ◽  
And Oxidative Stress

Oxidative stress is a potent activator of the Vascular endothelial growth factor (VEGF) gene in gastric carcinoma cells

2001 ◽  
Vol 120 (5) ◽  
pp. A5 ◽  
Author(s):  
Schaeter Georgia ◽  
Bertram Wiedenmann ◽  
Stefan Rosewicz ◽  
Thorsten Cramer ◽  
Michael Hoecker
Keyword(s):  
Oxidative Stress ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Gastric Carcinoma ◽  
Carcinoma Cells ◽  
Vascular Endothelial ◽  
Vegf Gene ◽  
Endothelial Growth Factor
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