Pericellular proteolysis by matrix metalloproteinase-7 is differentially modulated by cholesterol sulfate, sulfatide, and cardiolipin

FEBS Journal ◽  
2014 ◽  
Vol 281 (15) ◽  
pp. 3346-3356 ◽  
Author(s):  
Kazuhiro Yamamoto ◽  
Kaoru Miyazaki ◽  
Shouichi Higashi
Keyword(s):  
Matrix Metalloproteinase ◽  
Cholesterol Sulfate ◽  
Matrix Metalloproteinase 7 ◽  
Pericellular Proteolysis

scholarly journals Identification of Amino Acid Residues of Matrix Metalloproteinase-7 Essential for Binding to Cholesterol Sulfate

2008 ◽  
Vol 283 (51) ◽  
pp. 35735-35744 ◽  
Author(s):  
Shouichi Higashi ◽  
Miwa Oeda ◽  
Kazuhiro Yamamoto ◽  
Kaoru Miyazaki
Keyword(s):  
Amino Acid ◽  
Matrix Metalloproteinase ◽  
Amino Acid Residues ◽  
Cholesterol Sulfate ◽  
Matrix Metalloproteinase 7

Effects of heparin and cholesterol sulfate on the activity and stability of human matrix metalloproteinase 7

2014 ◽  
Vol 78 (1) ◽  
pp. 41-48 ◽  
Author(s):  
Vimbai Samukange ◽  
Kiyoshi Yasukawa ◽  
Kuniyo Inouye
Keyword(s):  
Matrix Metalloproteinase ◽  
Cholesterol Sulfate ◽  
Matrix Metalloproteinase 7

scholarly journals Divergent functions for airway epithelial matrix metalloproteinase 7 and retinoic acid in experimental asthma

2009 ◽  
Vol 10 (5) ◽  
pp. 496-503 ◽  
Author(s):  
Sangeeta Goswami ◽  
Pornpimon Angkasekwinai ◽  
Ming Shan ◽  
Kendra J Greenlee ◽  
Wade T Barranco ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Matrix Metalloproteinase ◽  
Airway Epithelial ◽  
Matrix Metalloproteinase 7

scholarly journals Current Concepts of Biliary Atresia and Matrix Metalloproteinase-7: A Review of Literature

2020 ◽  
Vol 7 ◽  
Author(s):  
Mark Nomden ◽  
Leonie Beljaars ◽  
Henkjan J. Verkade ◽  
Jan B. F. Hulscher ◽  
Peter Olinga
Keyword(s):  
Immune Response ◽  
Liver Fibrosis ◽  
Pulmonary Fibrosis ◽  
Matrix Metalloproteinase ◽  
Biliary Atresia ◽  
Adaptive Immune Response ◽  
Cell Contact ◽  
T Helper 1 ◽  
Matrix Metalloproteinase 7

Biliary atresia (BA) is a rare cholangiopathy of infancy in which the bile ducts obliterate, leading to profound cholestasis and liver fibrosis. BA is hypothesized to be caused by a viral insult that leads to over-activation of the immune system. Patients with BA are surgically treated with a Kasai portoenterostomy (KPE), which aims to restore bile flow from the liver to the intestines. After KPE, progressive liver fibrosis is often observed in BA patients, even despite surgical success and clearance of their jaundice. The innate immune response is involved during the initial damage to the cholangiocytes and further differentiation of the adaptive immune response into a T-helper 1 cell (Th1) response. Multiple studies have shown that there is continuing elevation of involved cytokines that can lead to the progressive liver fibrosis. However, the mechanism by which the progressive injury occurs is not fully elucidated. Recently, matrix metalloproteinase-7 (MMP-7) has been investigated to be used as a biomarker to diagnose BA. MMPs are involved in extracellular matrix (ECM) turnover, but also have non-ECM related functions. The role of MMP-7 and other MMPs in liver fibrosis is just starting to be elucidated. Multiple studies have shown that serum MMP-7 measurements are able to accurately diagnose BA in a cohort of cholestatic patients while hepatic MMP-7 expression correlated with BA-related liver fibrosis. While the mechanism by which MMP-7 can be involved in the pathophysiology of BA is unclear, MMP-7 has been investigated in other fibrotic pathologies such as renal and idiopathic pulmonary fibrosis. MMP-7 is involved in Wnt/β-catenin signaling, reducing cell-to-cell contact by shedding of E-cadherin, amplifying inflammation and fibrosis via osteopontin (OPN) and TNF-α while it also appears to play a role in induction of angiogenesis This review aims to describe the current understandings of the pathophysiology of BA. Subsequently, we describe how MMP-7 is involved in other pathologies, such as renal and pulmonary fibrosis. Then, we propose how MMP-7 can potentially be involved in BA. By doing this, we aim to describe the putative role of MMP-7 as a prognostic biomarker in BA and to provide possible new therapeutic and research targets that can be investigated in the future.

scholarly journals Clinicopathological significance of matrix metalloproteinase-7 protein expression in esophageal cancer: a meta-analysis

2015 ◽  
pp. 3729 ◽  
Author(s):  
Bin Yang ◽  
Shuai Miao ◽  
Shi-Yao Zhou ◽  
Chun-Shan Han ◽  
Le-Ning Zhang ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Matrix Metalloproteinase ◽  
Protein Expression ◽  
Meta Analysis ◽  
Matrix Metalloproteinase 7 ◽  
Clinicopathological Significance

scholarly journals Blood-brain barrier dysfunction significantly correlates with serum matrix metalloproteinase-7 (MMP-7) following traumatic brain injury

2021 ◽  
pp. 102741
Author(s):  
Paul Nichols ◽  
Javier Urriola ◽  
Stephanie Miller ◽  
Tracey Bjorkman ◽  
Kate Mahady ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Matrix Metalloproteinase ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Barrier Dysfunction ◽  
Blood Brain ◽  
Matrix Metalloproteinase 7

scholarly journals Matrilysin (Matrix Metalloproteinase-7) Mediates E-Cadherin Ectodomain Shedding in Injured Lung Epithelium

2003 ◽  
Vol 162 (6) ◽  
pp. 1831-1843 ◽  
Author(s):  
John K. McGuire ◽  
Qinglang Li ◽  
William C. Parks
Keyword(s):  
Matrix Metalloproteinase ◽  
Ectodomain Shedding ◽  
Lung Epithelium ◽  
Injured Lung ◽  
Matrix Metalloproteinase 7 ◽  
E Cadherin
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