scholarly journals The intrinsically disordered structural platform of the plant defence hub protein RPM1-interacting protein 4 provides insights into its mode of action in the host-pathogen interface and evolution of the nitrate-induced domain protein family

FEBS Journal ◽  
2014 ◽  
Vol 281 (17) ◽  
pp. 3955-3979 ◽  
Author(s):  
Xiaolin Sun ◽  
David R. Greenwood ◽  
Matthew D. Templeton ◽  
David S. Libich ◽  
Tony K. McGhie ◽  
...  
Keyword(s):  
Mode Of Action ◽  
Plant Defence ◽  
Protein Family ◽  
Interacting Protein ◽  
Intrinsically Disordered ◽  
Host Pathogen ◽  
Domain Protein

Identification of indeterminate domain protein family genes associated with flowering time in maize

2019 ◽  
Vol 45 (4) ◽  
pp. 499
Author(s):  
Yun-Fu LI ◽  
Jing-Xian WANG ◽  
Yan-Fang DU ◽  
Hua-Wen ZOU ◽  
Zu-Xin ZHANG
Keyword(s):  
Flowering Time ◽  
Protein Family ◽  
Domain Protein

scholarly journals 4E Interacting Protein as a Potential Novel Drug Target for Nucleoside Analogues in Trypanosoma Brucei

2021 ◽  
Vol 9 (4) ◽  
pp. 826
Author(s):  
Dorien Mabille ◽  
Camila Cardoso Santos ◽  
Rik Hendrickx ◽  
Mathieu Claes ◽  
Peter Takac ◽  
...  
Keyword(s):  
Mode Of Action ◽  
Drug Target ◽  
Drug Targets ◽  
De Novo ◽  
Treatment Options ◽  
Adenosine Kinase ◽  
Nucleoside Analogues ◽  
Purine Salvage ◽  
Interacting Protein ◽  
Novel Drug

Human African trypanosomiasis is a neglected parasitic disease for which the current treatment options are quite limited. Trypanosomes are not able to synthesize purines de novo and thus solely depend on purine salvage from the host environment. This characteristic makes players of the purine salvage pathway putative drug targets. The activity of known nucleoside analogues such as tubercidin and cordycepin led to the development of a series of C7-substituted nucleoside analogues. Here, we use RNA interference (RNAi) libraries to gain insight into the mode-of-action of these novel nucleoside analogues. Whole-genome RNAi screening revealed the involvement of adenosine kinase and 4E interacting protein into the mode-of-action of certain antitrypanosomal nucleoside analogues. Using RNAi lines and gene-deficient parasites, 4E interacting protein was found to be essential for parasite growth and infectivity in the vertebrate host. The essential nature of this gene product and involvement in the activity of certain nucleoside analogues indicates that it represents a potential novel drug target.

scholarly journals The putatively protective Onchocerca volvulus neuronal protein E1 is a member of the death domain protein family

FEBS Letters ◽  
1996 ◽  
Vol 390 (1) ◽  
pp. 21-24 ◽  
Author(s):  
K.D. Erttmann ◽  
A. Domeyer ◽  
M. Gallin
Keyword(s):  
Protein Family ◽  
Onchocerca Volvulus ◽  
Death Domain ◽  
Neuronal Protein ◽  
Domain Protein

scholarly journals Manganese toxicity and Saccharomyces cerevisiae Mam3p, a member of the ACDP (ancient conserved domain protein) family

2005 ◽  
Vol 386 (3) ◽  
pp. 479-487 ◽  
Author(s):  
Mei YANG ◽  
Laran T. JENSEN ◽  
Allison J. GARDNER ◽  
Valeria C. CULOTTA
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Integral Membrane Protein ◽  
Manganese Toxicity ◽  
Protein Family ◽  
Neurological Deficits ◽  
Yeast Saccharomyces Cerevisiae ◽  
Conserved Domain ◽  
Genetic Epistasis ◽  
Accumulation Of Metals ◽  
Domain Protein

Manganese is an essential, but potentially toxic, trace metal in biological systems. Overexposure to manganese is known to cause neurological deficits in humans, but the pathways that lead to manganese toxicity are largely unknown. We have employed the bakers' yeast Saccharomyces cerevisiae as a model system to identify genes that contribute to manganese-related damage. In a genetic screen for yeast manganese-resistance mutants, we identified S. cerevisiae MAM3 as a gene which, when deleted, would increase cellular tolerance to toxic levels of manganese and also increased the cell's resistance towards cobalt and zinc. By sequence analysis, Mam3p shares strong similarity with the mammalian ACDP (ancient conserved domain protein) family of polypeptides. Mutations in human ACDP1 have been associated with urofacial (Ochoa) syndrome. However, the functions of eukaryotic ACDPs remain unknown. We show here that S. cerevisiae MAM3 encodes an integral membrane protein of the yeast vacuole whose expression levels directly correlate with the degree of manganese toxicity. Surprisingly, Mam3p contributes to manganese toxicity without any obvious changes in vacuolar accumulation of metals. Furthermore, through genetic epistasis studies, we demonstrate that MAM3 operates independently of the well-established manganese-trafficking pathways in yeast, involving the manganese transporters Pmr1p, Smf2p and Pho84p. This is the first report of a eukaryotic ACDP family protein involved in metal homoeostasis.

scholarly journals Arabidopsis RADICAL-INDUCED CELL DEATH1 Belongs to the WWE Protein–Protein Interaction Domain Protein Family and Modulates Abscisic Acid, Ethylene, and Methyl Jasmonate Responses

2004 ◽  
Vol 16 (7) ◽  
pp. 1925-1937 ◽  
Author(s):  
Reetta Ahlfors ◽  
Saara Lång ◽  
Kirk Overmyer ◽  
Pinja Jaspers ◽  
Mikael Brosché ◽  
...  
Keyword(s):  
Abscisic Acid ◽  
Methyl Jasmonate ◽  
Protein Interaction ◽  
Protein Family ◽  
Interaction Domain ◽  
Protein Protein Interaction ◽  
Domain Protein

scholarly journals Deciphering the mode of action and host recognition of bacterial type III effectors

2010 ◽  
Vol 37 (10) ◽  
pp. 926 ◽  
Author(s):  
Selena Gimenez-Ibanez ◽  
Dagmar R. Hann ◽  
John P. Rathjen
Keyword(s):  
Mode Of Action ◽  
Pathogenic Bacteria ◽  
Plant Immunity ◽  
Plant Defence ◽  
Host Recognition ◽  
Type Iii Effectors ◽  
Host Cytoplasm ◽  
Host Plasma Membrane ◽  
Defence Responses ◽  
Bacterial Effectors

Plant pathogenic bacteria adhere to cell walls and remain external to the cell throughout the pathogenic lifecycle, where they elicit host immunity through host plasma membrane localised receptors. To be successful pathogens, bacteria must suppress these defence responses, which they do by secreting a suite of virulence effector molecules into the host cytoplasm. However, effectors themselves can act as elicitors after perception by intracellular host immune receptors, thus, re-activating plant immunity. Bacterial effectors generally target host molecules through specific molecular activities to defeat plant defence responses. Although effectors can be used as tools to elucidate components of plant immunity, only a handful of these molecular targets are known and much remains to be learnt about effector strategies for bacterial pathogenicity. This review highlights recent advances in our understanding of the mode of action of bacterial effectors, which in the future will lead to improvements in agriculture.

(Z)-3-hexenyl butyrate: efficacy and mode of action in plant defence and tolerance to stress

2019 ◽  
Vol 305 ◽  
pp. S14-S15
Author(s):  
C. Paya ◽  
M. Lopez Gresa ◽  
I. Rodrigo Bravo ◽  
J. Belles ◽  
P. Lison
Keyword(s):  
Mode Of Action ◽  
Plant Defence
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