Phosphorylation of H2A.XTyr39positively regulates DNA damage response and is linked to cancer progression

FEBS Journal ◽  
2016 ◽  
Vol 283 (24) ◽  
pp. 4462-4473 ◽  
Author(s):  
Yan Liu ◽  
Yue-Hong Long ◽  
Shu-Qing Wang ◽  
Yu-Feng Li ◽  
Jing-Hua Zhang
Keyword(s):  
Dna Damage ◽  
Dna Damage Response ◽  
Cancer Progression ◽  
Damage Response

scholarly journals ADAR1 Transcriptome editing promotes breast cancer progression through the regulation of cell cycle and DNA damage response

2020 ◽  
Vol 1867 (8) ◽  
pp. 118716 ◽  
Author(s):  
Eduardo A. Sagredo ◽  
Alfredo I. Sagredo ◽  
Alejandro Blanco ◽  
Pamela Rojas De Santiago ◽  
Solange Rivas ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Cancer Progression ◽  
Breast Cancer Progression ◽  
Damage Response ◽  
Regulation Of Cell Cycle

RAS/MAPK signaling functions in oxidative stress, DNA damage response and cancer progression

2019 ◽  
Vol 234 (9) ◽  
pp. 14951-14965 ◽  
Author(s):  
Setareh Rezatabar ◽  
Ansar Karimian ◽  
Vahid Rameshknia ◽  
Hadi Parsian ◽  
Maryam Majidinia ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Cancer Progression ◽  
Mapk Signaling ◽  
Damage Response

scholarly journals NCAPH regulates gastric cancer progression through DNA damage response

Neoplasma ◽  
2021 ◽  
Author(s):  
Yan Wang ◽  
Jun-Qiang Li ◽  
Zhi-Liang Yang ◽  
Long Wang ◽  
Jun-Chang Zhang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Cancer Progression ◽  
Damage Response ◽  
Gastric Cancer Progression

2-Methoxy-6-Acetyl-7-Methyljuglone (MAM) Induces iNOS/NO-mediated DNA Damage Response through Activation of MAPKs Pathways

2018 ◽  
Vol 18 (6) ◽  
pp. 903-913 ◽  
Author(s):  
Yanan Niu ◽  
Renyikun Yuan ◽  
Hongwei Gao ◽  
Jin-Jian Lu ◽  
Qi Kong ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Dna Damage ◽  
Cell Death ◽  
Dna Damage Response ◽  
Cancer Progression ◽  
A549 Cells ◽  
No Production ◽  
Damage Response

Background：There are inconsistent reports about the role of Nitric Oxide (NO) in cancer progression and prevention. Quinones demonstrate significant anti-cancer activities both in vitro and in vivo. Objective： We investigated the effect of 2-methoxy-6-acetyl-7-methyljuglone (MAM), a natural naphthoquinone isolated from Polygonum cuspidatum Sieb. et Zucc, on NO generation and its role in DNA damage in cancer cells. Methods: BEL-7402 and A549 cells were cultured and treated with MAM. The NO generation, DNA damage, and protein expression were determined. Results: MAM induced inducible nitric oxide synthase (iNOS)/NO-mediated DNA damage response through activation of MAPKs pathways. MAM induced DNA damage by activating ATM/Chk2. MAM increased iNOS expression, NO production, and MAPKs (JNK1/2, ERK1/2, and p38MAPK) phosphorylation in concentrationand time- dependent manners. Furthermore, iNOS inhibitor 1400W, iNOS siRNA, and NO scavenger hemoglobin (Hb) could significantly reverse MAM-induced DNA damage, ATM/Chk2 activation, NO production, and cell death. In addition, MAPKs inhibitors (SP600125, U0126, and SB203580) reversed MAM-induced cell death and ATM/Chk2 activation. MAM-induced cell death was partially reversed by 1400W and Hb but enhanced by L-arginine. Conclusion: These results suggested that MAM induced iNOS/NO activation and generation mediated by MAPKs pathways, which resulted in DNA damage.

Multiple Functions of Long Non-Coding RNAs in Oxidative Stress, DNA Damage Response and Cancer Progression

2017 ◽  
Vol 119 (1) ◽  
pp. 223-236 ◽  
Author(s):  
Sadra Samavarchi Tehrani ◽  
Ansar Karimian ◽  
Hadi Parsian ◽  
Maryam Majidinia ◽  
Bahman Yousefi
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Cancer Progression ◽  
Multiple Functions ◽  
Damage Response ◽  
Non Coding Rnas

2118-P: Regulation of Ataxia-Telangiectasia and Rad3-Related (ATR)–Dependent DNA Damage Response by Nitric Oxide in ß-Cells

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 2118-P
Author(s):  
CHAY TENG YEO ◽  
BRYNDON OLESON ◽  
JOHN A. CORBETT ◽  
JAMIE K. SCHNUCK
Keyword(s):  
Nitric Oxide ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Ataxia Telangiectasia ◽  
Damage Response
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