scholarly journals NCAPH regulates gastric cancer progression through DNA damage response

Neoplasma ◽  
2021 ◽  
Author(s):  
Yan Wang ◽  
Jun-Qiang Li ◽  
Zhi-Liang Yang ◽  
Long Wang ◽  
Jun-Chang Zhang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Cancer Progression ◽  
Damage Response ◽  
Gastric Cancer Progression

scholarly journals 144P Clinical implication of DNA damage response gene in patients with stage II or III gastric cancer

2020 ◽  
Vol 31 ◽  
pp. S1297
Author(s):  
I.G. Hwang ◽  
S.E. Park ◽  
J.H. Choi ◽  
H.S. Kim ◽  
H.Y. Min ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Clinical Implication ◽  
Stage Ii ◽  
Response Gene ◽  
Damage Response

scholarly journals ADAR1 Transcriptome editing promotes breast cancer progression through the regulation of cell cycle and DNA damage response

2020 ◽  
Vol 1867 (8) ◽  
pp. 118716 ◽  
Author(s):  
Eduardo A. Sagredo ◽  
Alfredo I. Sagredo ◽  
Alejandro Blanco ◽  
Pamela Rojas De Santiago ◽  
Solange Rivas ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Cancer Progression ◽  
Breast Cancer Progression ◽  
Damage Response ◽  
Regulation Of Cell Cycle

RAS/MAPK signaling functions in oxidative stress, DNA damage response and cancer progression

2019 ◽  
Vol 234 (9) ◽  
pp. 14951-14965 ◽  
Author(s):  
Setareh Rezatabar ◽  
Ansar Karimian ◽  
Vahid Rameshknia ◽  
Hadi Parsian ◽  
Maryam Majidinia ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Cancer Progression ◽  
Mapk Signaling ◽  
Damage Response

Phosphorylation of H2A.XTyr39positively regulates DNA damage response and is linked to cancer progression

FEBS Journal ◽  
2016 ◽  
Vol 283 (24) ◽  
pp. 4462-4473 ◽  
Author(s):  
Yan Liu ◽  
Yue-Hong Long ◽  
Shu-Qing Wang ◽  
Yu-Feng Li ◽  
Jing-Hua Zhang
Keyword(s):  
Dna Damage ◽  
Dna Damage Response ◽  
Cancer Progression ◽  
Damage Response

scholarly journals Upregulation of the APE1 and H2AX genes and miRNAs involved in DNA damage response and repair in gastric cancer

2019 ◽  
Vol 6 (2) ◽  
pp. 176-184 ◽  
Author(s):  
Fernanda S. Manoel-Caetano ◽  
Ana Flávia T. Rossi ◽  
Gabriela Calvet de Morais ◽  
Fábio Eduardo Severino ◽  
Ana Elizabete Silva
Keyword(s):  
Gastric Cancer ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Damage Response

scholarly journals DNA Damage Response-Related Proteins in Gastric Cancer: ATM, Chk2 and p53 Expression and Their Prognostic Value

Pathobiology ◽  
2014 ◽  
Vol 81 (1) ◽  
pp. 25-35 ◽  
Author(s):  
Hee Eun Lee ◽  
Nayoung Han ◽  
Min A Kim ◽  
Hye Seung Lee ◽  
Han-Kwang Yang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Prognostic Value ◽  
P53 Expression ◽  
Damage Response ◽  
Related Proteins

scholarly journals Bcl-2-associated transcription factor 1 Ser290 phosphorylation mediates DNA damage response and regulates radiosensitivity in gastric cancer

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Jia Liu ◽  
Jingyi Li ◽  
Zhao Sun ◽  
Yangmiao Duan ◽  
Fengqin Wang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Dna Damage ◽  
Transcription Factor ◽  
Protein Phosphorylation ◽  
Dna Damage Response ◽  
High Resolution Mass Spectrometry ◽  
Gene Set Enrichment Analysis ◽  
Label Free ◽  
Damage Response ◽  
Transcription Factor 1

Abstract Background DNA damage response plays critical roles in tumor pathogenesis and radiotherapy resistance. Protein phosphorylation is a critical mechanism in regulation of DNA damage response; however, the key mediators for radiosensitivity in gastric cancer still needs further exploration. Methods A quick label-free phosphoproteomics using high-resolution mass spectrometry and an open search approach was applied to paired tumor and adjacent tissues from five patients with gastric cancer. The dysregulated phosphoproteins were identified and their associated-pathways analyzed using Gene Set Enrichment Analysis (GSEA). The mostly regulated phosphoproteins and their potential functions were validated by the specific antibodies against the phosphorylation sites. Specific protein phosphorylation was further analyzed by functional and clinical approaches. Results 832 gastric cancer-associated unique phosphorylated sites were identified, among which 25 were up- and 52 down-regulated. Markedly, the dysregulated phosphoproteins were primarily enriched in DNA-damage-response-associated pathways. Particularly, the phosphorylation of Bcl-2-associated transcription factor 1 (BCLAF1) at Ser290 was significantly upregulated in tumor. The upregulation of BCLAF1 Ser290 phosphorylation (pBCLAF1 (Ser290)) in tumor was confirmed by tissue microarray studies and further indicated in association with poor prognosis of gastric cancer patients. Eliminating the phosphorylation of BCLAF1 at Ser290 suppressed gastric cancer (GC) cell proliferation. Upregulation of pBCLAF1 (Ser290) was found in association with irradiation-induced γ-H2AX expression in the nucleus, leading to an increased DNA damage repair response, and a marked inhibition of irradiation-induced cancer cell apoptosis. Conclusions The phosphorylation of BCLAF1 at Ser290 is involved in the regulation of DNA damage response, indicating an important target for the resistance of radiotherapy.

2-Methoxy-6-Acetyl-7-Methyljuglone (MAM) Induces iNOS/NO-mediated DNA Damage Response through Activation of MAPKs Pathways

2018 ◽  
Vol 18 (6) ◽  
pp. 903-913 ◽  
Author(s):  
Yanan Niu ◽  
Renyikun Yuan ◽  
Hongwei Gao ◽  
Jin-Jian Lu ◽  
Qi Kong ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Dna Damage ◽  
Cell Death ◽  
Dna Damage Response ◽  
Cancer Progression ◽  
A549 Cells ◽  
No Production ◽  
Damage Response

Background：There are inconsistent reports about the role of Nitric Oxide (NO) in cancer progression and prevention. Quinones demonstrate significant anti-cancer activities both in vitro and in vivo. Objective： We investigated the effect of 2-methoxy-6-acetyl-7-methyljuglone (MAM), a natural naphthoquinone isolated from Polygonum cuspidatum Sieb. et Zucc, on NO generation and its role in DNA damage in cancer cells. Methods: BEL-7402 and A549 cells were cultured and treated with MAM. The NO generation, DNA damage, and protein expression were determined. Results: MAM induced inducible nitric oxide synthase (iNOS)/NO-mediated DNA damage response through activation of MAPKs pathways. MAM induced DNA damage by activating ATM/Chk2. MAM increased iNOS expression, NO production, and MAPKs (JNK1/2, ERK1/2, and p38MAPK) phosphorylation in concentrationand time- dependent manners. Furthermore, iNOS inhibitor 1400W, iNOS siRNA, and NO scavenger hemoglobin (Hb) could significantly reverse MAM-induced DNA damage, ATM/Chk2 activation, NO production, and cell death. In addition, MAPKs inhibitors (SP600125, U0126, and SB203580) reversed MAM-induced cell death and ATM/Chk2 activation. MAM-induced cell death was partially reversed by 1400W and Hb but enhanced by L-arginine. Conclusion: These results suggested that MAM induced iNOS/NO activation and generation mediated by MAPKs pathways, which resulted in DNA damage.

scholarly journals Rap1 is indispensable for TRF2 function in etoposide-induced DNA damage response in gastric cancer cell line

Oncogenesis ◽  
2015 ◽  
Vol 4 (3) ◽  
pp. e144-e144 ◽  
Author(s):  
X Li ◽  
W Liu ◽  
H Wang ◽  
L Yang ◽  
Y Li ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Dna Damage ◽  
Cell Line ◽  
Cancer Cell ◽  
Dna Damage Response ◽  
Gastric Cancer Cell ◽  
Gastric Cancer Cell Line ◽  
Cancer Cell Line ◽  
Damage Response
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