Age-related changes in skin barrier function - Quantitative evaluation of 150 female subjects

2012 ◽  
Vol 35 (2) ◽  
pp. 183-190 ◽  
Author(s):  
S. Luebberding ◽  
N. Krueger ◽  
M. Kerscher
Keyword(s):  
Quantitative Evaluation ◽  
Barrier Function ◽  
Skin Barrier ◽  
Skin Barrier Function ◽  
Age Related ◽  
Age Related Changes ◽  
Female Subjects

Influence of sportive activity on skin barrier function: a quantitative evaluation of 60 athletes

2013 ◽  
Vol 52 (6) ◽  
pp. 745-749 ◽  
Author(s):  
Stefanie Luebberding ◽  
Lea Kolbe ◽  
Martina Kerscher
Keyword(s):  
Quantitative Evaluation ◽  
Barrier Function ◽  
Skin Barrier ◽  
Skin Barrier Function

Age-related changes in skin mechanical properties: a quantitative evaluation of 120 female subjects

2011 ◽  
Vol 17 (2) ◽  
pp. 141-148 ◽  
Author(s):  
Nils Krueger ◽  
Stefanie Luebberding ◽  
Mareike Oltmer ◽  
Meike Streker ◽  
Martina Kerscher
Keyword(s):  
Mechanical Properties ◽  
Quantitative Evaluation ◽  
Age Related ◽  
Age Related Changes ◽  
Female Subjects

A study on the quantitative evaluation of skin barrier function

2015 ◽  
Author(s):  
Tomomi Maruyama ◽  
Yasuhiro Kabetani ◽  
Michiko Kido ◽  
Kenji Yamada ◽  
Hirotoshi Oikaze ◽  
...  
Keyword(s):  
Quantitative Evaluation ◽  
Barrier Function ◽  
Skin Barrier ◽  
Skin Barrier Function

Skin Barrier Function Repair Is the Next Step in Atopic Dermatitis Treatment

2006 ◽  
Vol 37 (11) ◽  
pp. 19
Author(s):  
DAMIAN MCNAMARA
Keyword(s):  
Atopic Dermatitis ◽  
Barrier Function ◽  
Skin Barrier ◽  
Skin Barrier Function

Instrumental evaluation of skin barrier function and clinical outcomes during dupilumab treatment for atopic dermatitis: An observational study

2021 ◽  
Author(s):  
Antonio Cristaudo ◽  
Flavia Pigliacelli ◽  
Francesca Sperati ◽  
Diego Orsini ◽  
Norma Cameli ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Observational Study ◽  
Clinical Outcomes ◽  
Barrier Function ◽  
Skin Barrier ◽  
Skin Barrier Function ◽  
Instrumental Evaluation

scholarly journals EGFR inhibitors switch keratinocytes from a proliferative to a differentiative phenotype affecting epidermal development and barrier function

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Nicolas Joly-Tonetti ◽  
Thomas Ondet ◽  
Mario Monshouwer ◽  
Georgios N. Stamatas
Keyword(s):  
Growth Factor ◽  
Barrier Function ◽  
Kinase Inhibitors ◽  
Treatment Protocol ◽  
Growth Factor Receptor ◽  
Skin Barrier ◽  
Keratinocyte Differentiation ◽  
Skin Barrier Function ◽  
Epidermal Keratinocytes ◽  
Epidermal Structure

Abstract Background Cutaneous adverse drug reactions (CADR) associated with oncology therapy involve 45–100% of patients receiving kinase inhibitors. Such adverse reactions may include skin inflammation, infection, pruritus and dryness, symptoms that can significantly affect the patient’s quality of life. To prevent severe skin damages dose adjustment or drug discontinuation is often required, interfering with the prescribed oncology treatment protocol. This is particularly the case of Epidermal Growth Factor Receptor inhibitors (EGFRi) targeting carcinomas. Since the EGFR pathway is pivotal for epidermal keratinocytes, it is reasonable to hypothesize that EGFRi also affect these cells and therefore interfere with the epidermal structure formation and skin barrier function. Methods To test this hypothesis, the effects of EGFRi and Vascular Endothelial Growth Factor Receptor inhibitors (VEGFRi) at therapeutically relevant concentrations (3, 10, 30, 100 nM) were assessed on proliferation and differentiation markers of human keratinocytes in a novel 3D micro-epidermis tissue culture model. Results EGFRi directly affect basal keratinocyte growth, leading to tissue size reduction and switching keratinocytes from a proliferative to a differentiative phenotype, as evidenced by decreased Ki67 staining and increased filaggrin, desmoglein-1 and involucrin expression compared to control. These effects lead to skin barrier impairment, which can be observed in a reconstructed human epidermis model showing a decrease in trans-epidermal water loss rates. On the other hand, pan-kinase inhibitors mainly targeting VEGFR barely affect keratinocyte differentiation and rather promote a proliferative phenotype. Conclusions This study contributes to the mechanistic understanding of the clinically observed CADR during therapy with EGFRi. These in vitro results suggest a specific mode of action of EGFRi by directly affecting keratinocyte growth and barrier function.

scholarly journals Skin Barrier Function in Psoriasis and Atopic Dermatitis: Transepidermal Water Loss and Temperature as Useful Tools to Assess Disease Severity

2021 ◽  
Vol 10 (2) ◽  
pp. 359 ◽  
Author(s):  
Trinidad Montero-Vilchez ◽  
María-Victoria Segura-Fernández-Nogueras ◽  
Isabel Pérez-Rodríguez ◽  
Miguel Soler-Gongora ◽  
Antonio Martinez-Lopez ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Disease Severity ◽  
Water Loss ◽  
Barrier Function ◽  
Skin Barrier ◽  
Transepidermal Water Loss ◽  
Diagnostic Tools ◽  
Psoriatic Skin ◽  
Skin Barrier Function ◽  
Healthy Controls

Multiple diagnostic tools are used to evaluate psoriasis and atopic dermatitis (AD) severity, but most of them are based on subjective components. Transepidermal water loss (TEWL) and temperature are skin barrier function parameters that can be objectively measured and could help clinicians to evaluate disease severity accurately. Thus, the aims of this study are: (1) to compare skin barrier function between healthy skin, psoriatic skin and AD skin; and (2) to assess if skin barrier function parameters could predict disease severity. A cross-sectional study was designed, and epidermal barrier function parameters were measured. The study included 314 participants: 157 healthy individuals, 92 psoriatic patients, and 65 atopic dermatitis patients. TEWL was significantly higher, while stratum corneum hydration (SCH) (8.71 vs. 38.43 vs. 44.39 Arbitrary Units (AU)) was lower at psoriatic plaques than at uninvolved psoriatic skin and healthy controls. Patients with both TEWL > 13.85 g·m−2h−1 and temperature > 30.85 °C presented a moderate/severe psoriasis (psoriasis area severity index (PASI) ≥ 7), with a specificity of 76.3%. TEWL (28.68 vs. 13.15 vs. 11.60 g·m−2 h−1) and temperature were significantly higher, while SCH (25.20 vs. 40.95 vs. 50.73 AU) was lower at AD eczematous lesions than uninvolved AD skin and healthy controls. Patients with a temperature > 31.75 °C presented a moderate/severe AD (SCORing Atopic Dermatitis (SCORAD) ≥ 37) with a sensitivity of 81.8%. In conclusion, temperature and TEWL values may help clinicians to determine disease severity and select patients who need intensive treatment.

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