Effect of Ectoin Dermatitis Cream 7% on Skin Hydration and Skin Barrier Function

2019 ◽  
Author(s):  
Keyword(s):  
Barrier Function ◽  
Skin Barrier ◽  
Skin Hydration ◽  
Skin Barrier Function

scholarly journals Immediate and long-term effects of polysaccharides-based formulations on human skin

2012 ◽  
Vol 48 (3) ◽  
pp. 547-555 ◽  
Author(s):  
Flavio Bueno de Camargo Junior ◽  
Lorena Rigo Gaspar ◽  
Patrícia Maria Berardo Gonçalves Maia Campos
Keyword(s):  
Barrier Function ◽  
Skin Barrier ◽  
Skin Hydration ◽  
Skin Barrier Function ◽  
Cell Renewal ◽  
Myrtus Communis ◽  
Long Term Effects ◽  
Subjective Analysis ◽  
Cosmetic Formulations

A new trend in cosmetic formulations is the use of biotechnological raw materials as the polysaccharides from Klebsiella pneumoniae, which are supposed to enhance cell renewal, improve skin hydration and micro-relief. Botanical extracts of Myrtus communis leaves contain different sugars, which may provide the same benefits. Thus, the objective of this study was to evaluate through objective and subjective analysis the immediate and long-term effects of cosmetic formulations containing polysaccharides biotechnologically-originated and / or the ones contained in Myrtus communis extracts. Three polysaccharide-based and placebo formulations were applied on the forearm skin of 40 volunteers. Skin hydration, transepidermal water loss (TEWL), viscoelasticity and skin micro-relief measurements were made before and 2 hours after a single application and after 15 and 30 day-periods of daily applications. Answers to a questionnaire about perceptions of formulation cosmetic features constituted the subjective analysis. All polysaccharide-based formulations enhanced skin hydration. Formulations with isolated or combined active substances improved skin barrier function as compared to placebo, in the short and long term studies. Formulations containing Myrtus communis extracts had the highest acceptance. Results suggest that daily use of formulations containing these substances is important for protection of the skin barrier function.

scholarly journals Effect of Topically Applied Wikstroemia dolichantha Diels on the Development of Atopic Dermatitis-Like Skin Symptoms in Mice

Nutrients ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 914 ◽  
Author(s):  
Jonghwan Jegal ◽  
No-June Park ◽  
Tae-Young Kim ◽  
Sangho Choi ◽  
Sang Woo Lee ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Barrier Function ◽  
Immunoglobulin E ◽  
Skin Barrier ◽  
Skin Lesions ◽  
Transepidermal Water Loss ◽  
Skin Hydration ◽  
Interleukin 4 ◽  
Skin Barrier Function ◽  
Skin Symptoms

Plants of the genus Wikstroemia are traditionally used to treat inflammatory diseases like bronchitis and rheumatoid arthritis. In the present study, the anti-atopic effects of an EtOH extract of Wikstroemia dolichantha (WDE) on oxazolone- and DNCB (2,4-dinitrochlorobenzene)-induced dermatitis in mice were investigated. Both ears of BALB/c mice were exposed to oxazolone, and dorsal skins of SKH-1 hairless mice were sensitized with DNCB to induce acute eczematous atopic skin lesions. 1% WDE was applied daily to oxazolone- and DNCB-induced AD mice for two or three weeks, respectively. Total IL-4 and IgE concentrations in serum, transepidermal water loss (TEWL) and skin hydration were assessed. High-performance liquid chromatography/mass spectrometry (HPLC/MS) was used to determine the composition of WDE. Dermal application of 1% WDE grossly and histopathologically improved oxazolone- and DNCB-induced AD skin symptoms. Epidermal thickness and mast cell infiltration were significantly lower in animals treated with WDE than in vehicle controls. Furthermore, in addition to reducing DNCB-induced increases in serum IL-4 (interleukin 4) and IgE (immunoglobulin E) levels, WDE also decreased TEWL and increased skin hydration (indicative of improved skin barrier function). The four flavonoids taxifolin, aromadendrin, padmatin and chamaejasmine were tentatively identified in WDE by HPLC-DAD/QTOF-MS. The above results show WDE protected against oxazolone- and DNCB-induced AD in mice by down-regulating the TH2-associated cytokine IL-4 and improving skin barrier function and suggest WDE might be useful for the management of atopic dermatitis.

scholarly journals Antenatal Corticosteroids and Postnatal Fluid Restriction Produce Differential Effects on AQP3 Expression, Water Handling, and Barrier Function in Perinatal Rat Epidermis

2010 ◽  
Vol 2010 ◽  
pp. 1-9 ◽  
Author(s):  
Johan Agren ◽  
Sergey Zelenin ◽  
Lill-Britt Svensson ◽  
Lene N. Nejsum ◽  
Soren Nielsen ◽  
...  
Keyword(s):  
Water Transport ◽  
Barrier Function ◽  
Skin Barrier ◽  
Skin Hydration ◽  
Skin Barrier Function ◽  
Fluid Restriction ◽  
Antenatal Corticosteroids ◽  
Differential Effects ◽  
Rat Pups ◽  
Water Handling

Loss of water through the immature skin can lead to hypothermia and dehydration in preterm infants. The water and glycerol channel aquaglyceroporin-3 (AQP3) is abundant in fetal epidermis and might influence epidermal water handling and transepidermal water flux around birth. To investigate the role of AQP3 in immature skin, we measuredin vivotransepidermal water transport and AQP3 expression in rat pups exposed to clinically relevant fluid homeostasis perturbations. Preterm (E18) rat pups were studied after antenatal corticosteroid exposure (ANS), and neonatal (P1) rat pups after an 18 h fast. Transepidermal water loss (TEWL) and skin hydration were determined, AQP3 mRNA was quantified by RT-PCR, and in-situ hybridization and immunocytochemistry were applied to map AQP3 expression. ANS resulted in an improved skin barrier (lower TEWL and skin hydration), while AQP3 mRNA and protein increased. Fasting led to loss of barrier integrity along with an increase in skin hydration. These alterations were not paralleled by any changes in AQP3. To conclude, antenatal corticosteroids and early postnatal fluid restriction produce differential effects on skin barrier function and epidermal AQP3 expression in the rat. In perinatal rats, AQP3 does not directlydeterminenet water transport through the skin.

scholarly journals The effect of Kanjiža peloid on skin hydration and skin barrier function

2020 ◽  
Vol 66 (03) ◽  
pp. 105-106
Author(s):  
Gábor Katona ◽  
Slađana Vojvodić ◽  
Marina Kalić ◽  
Miroslav S. Sarač ◽  
Attila Klimó ◽  
...  
Keyword(s):  
Barrier Function ◽  
Skin Barrier ◽  
Skin Hydration ◽  
Skin Barrier Function

scholarly journals Microbiome Profile in Adult Balanoposthitis Patients: Relationship with Redundant Prepuce, Skin Physical Barrier Status and Inflammation

2020 ◽  
Author(s):  
Meng Li ◽  
Jian-Xun Mao ◽  
Hang-Hang Jiang ◽  
Chun-Ming Huang ◽  
Xinghua Gao ◽  
...  
Keyword(s):  
Barrier Function ◽  
Skin Barrier ◽  
Transepidermal Water Loss ◽  
Skin Hydration ◽  
Skin Barrier Function ◽  
Physical Barrier ◽  
Staphylococcus Warneri ◽  
Prevotella Bivia ◽  
Microbiome Profile ◽  
Associated Species

Abstract Background: Balanoposthitis is a common inflammatory condition of male genitalia, the microbiota spectrum have not been determined thus far. To profile the microbiome in patients with balanoposthitis (BP), and healthy controls (HC), and investigate its correlation with redundant prepuce, severity of inflammation, and disrupted skin barrier function, including skin pH, Transepidermal Water Loss (TEWL), and skin hydration.Results: In general, the microbiota between BP and HC were similar. The microbiota composition was different between BP and HC with redundant prepuce. Staphylococcus warneri and Prevotella bivia are two most abundant BP-associated Species, and positively correlated with disease severity. The physio-barrier function is markedly impaired in BP, shown by decreased skin hydration, while increased TEWL and pH.Conclusions: Staphylococcus warneri and Prevotella bivia showed a strong correlation with balanoposthitis and may be pathogenic for the condition.

scholarly journals Two New Dexpanthenol-Containing Wash Gels: Skin Hydration, Barrier Function and Cosmetic Performance upon Single and Repeated Usage in Subjects with Dry Skin

Cosmetics ◽  
2021 ◽  
Vol 8 (2) ◽  
pp. 44
Author(s):  
Ana Barrionuevo-Gonzalez ◽  
Sonja Trapp ◽  
Raffaella de Salvo ◽  
Rozalia Olsavszky ◽  
Elena Alina Nanu ◽  
...  
Keyword(s):  
Barrier Function ◽  
Skin Barrier ◽  
Transepidermal Water Loss ◽  
The Body ◽  
Skin Hydration ◽  
Skin Barrier Function ◽  
Lauryl Sulfate ◽  
Dry Skin ◽  
Study Results ◽  
Forearm Skin

Two novel body/face wash gels enriched with emollient ingredients (including dexpanthenol) were developed for the daily care of dry skin. Two similarly designed 2-week studies (N = 42 each) were conducted to assess the biophysical and cosmetic performance of each of the new wash gels in healthy adults with dry skin. Instrumental measurements quantified the effects of the wash gels on stratum corneum (SC) hydration and transepidermal water loss (TEWL) (with and without a previous sodium lauryl sulfate (SLS) challenge) after single and repeated usage. Following single and repeated applications of the face wash gel to facial skin, as well as to dry SLS-undamaged and SLS-damaged skin of the forearm, skin hydration significantly increased. Similarly, after single and repeated usage of the body wash gel to dry SLS-undamaged and SLS-damaged skin of the forearm, skin moisturization increased significantly from baseline; comparisons with control areas provided inconsistent results for SLS-undamaged skin. No effects on TEWL were observed for either product. Both wash gels were well tolerated and the cosmetic performances were appreciated by the subjects. The study results suggest that daily use of the new wash gels was associated with significant skin-moisturizing effects without adversely affecting skin barrier function and repair.

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