Incidence of cutaneous squamous cell carcinoma in a New Zealand population of chronic lymphocytic leukaemia patients

AbstractBackgroundPatients with non-Hodgkin's lymphoma and chronic lymphocytic leukaemia are at an elevated risk of further malignancy. Head and neck squamous cell carcinoma often presents with cervical lymph node metastasis, and can pose a diagnostic challenge in patients with non-Hodgkin's lymphoma or chronic lymphocytic leukaemia who may have pre-existing palpable neck nodes.MethodsA retrospective case review of a health board was conducted to identify patients with head and neck squamous cell carcinoma with a previous diagnosis of non-Hodgkin's lymphoma or chronic lymphocytic leukaemia.ResultsFour patients with head and neck squamous cell carcinoma that developed after non-Hodgkin's lymphoma or chronic lymphocytic leukaemia were identified. Two patients had a background of non-Hodgkin's lymphoma treated with chemotherapy. The remaining two patients had a background of chronic lymphocytic leukaemia under active surveillance. Three out of the four patients died within 30 months of diagnosis.ConclusionHead and neck squamous cell carcinoma following non-Hodgkin's lymphoma or chronic lymphocytic leukaemia is aggressive. A heightened clinical suspicion is essential to facilitate early diagnosis and treatment of head and neck squamous cell carcinoma in patients with dual pathology.

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Squamous Cell Carcinoma of Lung Metastatic to a Mediastinal Lymph Node Involved by Chronic Lymphocytic Leukaemia / Small Lymphocytic Lymphoma, A Case Report with Review of Literature

North American Journal of Medicine and Science ◽

10.7156/v1i1p025 ◽

2008 ◽

Vol 1 (1) ◽

pp. 25

Author(s):

Iyare Izevbaye ◽

◽

Samuel Goodloe ◽

Frank Chen ◽

◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Case Report ◽

Lymph Node ◽

Chronic Lymphocytic Leukaemia ◽

Cell Carcinoma ◽

Squamous Cell ◽

Lymphocytic Leukaemia ◽

Mediastinal Lymph Node ◽

Review Of Literature ◽

Small Lymphocytic Lymphoma

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Aggressive cutaneous squamous cell carcinoma of the head and neck in patients with chronic lymphocytic leukaemia

The Journal of Laryngology & Otology ◽

10.1017/s0022215100134668 ◽

1996 ◽

Vol 110 (7) ◽

pp. 694-695 ◽

Cited By ~ 33

Author(s):

B. E. J. Hartley ◽

A. E. Searle ◽

N. M. Breach ◽

P. H. Rhys-Evans ◽

J. M. Henk

Keyword(s):

Squamous Cell Carcinoma ◽

Lymph Node ◽

Local Recurrence ◽

Chronic Lymphocytic Leukaemia ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Lymphocytic Leukaemia ◽

Management Plan ◽

High Tendency

AbstractWe describe multiple cutaneous squamous cell carcinomas of the head and neck in five patients with chronic lymphocytic leukaemia (CLL). When associated with CLL, cutaneous squamous cell carcinomata behave in a much more aggressive manner than otherwise expected. Four patients developed local recurrence after primary treatment. All five patients developed lymph node metastases containing squamous cell carcinoma. Three of five patients (60 per cent) had multiple primary lesions.Whereas the increased incidence of second cancers in CLL and notably of skin cancers is documented, little has been written to describe the aggressive behaviour of these tumours. It is important, when treating these patients, to be aware of the high tendency towards local recurrence and lymph node metastasis and to consider an aggressive management plan and careful follow-up.

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