KIR-HLA-A and B alleles of the Bw4 epitope against HIV infection in discordant heterosexual couples in Chaco Argentina

This article examines sociocultural expectations of sexual behavior and the reasons why not using condoms may be logical to married heterosexual couples in India. Married women who report monogamous sexual relationships with their husbands are a high-risk group for HIV infection in India. Based on the public health model and a population-based perspective on HIV infection prevention, this article illustrates the underlying mechanisms that link the role of women in society, holistic health beliefs, and cultural beliefs about the transmission of HIV with the precursors to nonuse of condoms. The author concludes that promoting condom use requires an emphasis on family health, not only as contraceptives. Challenges for reducing the social stigma and developing a comprehensive policy on HIV prevention and AIDS treatment and care are discussed.

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Risk factors for HIV infection among married couples in Rakai, Uganda: A cross-sectional study

10.21203/rs.2.15768/v1 ◽

2019 ◽

Author(s):

Anne M. Nabukenya ◽

Aminah Nambuusi ◽

Joseph KB Matovu

Keyword(s):

Risk Factors ◽

Hiv Infection ◽

Married Couples ◽

Cross Sectional Study ◽

Hiv Prevalence ◽

Bivariate Analysis ◽

Couple Relationships ◽

Heterosexual Couples ◽

Sectional Study ◽

Cross Sectional

Abstract Background: Evidence suggests that married couples are at an elevated risk of HIV infection. We explored the risk factors for HIV infection among married couples in settings with differing HIV prevalence in Rakai, Uganda.Methods: This was a cross-sectional study conducted among 664 heterosexual couples living in three HIV prevalence strata (low: 9-11.2%; medium: 11.4-20% or high HIV prevalence: 21% or higher) in Rakai District, south-western Uganda, between November 2013 and February 2014. Data were collected on socio-demographic and behavioural characteristics from all consenting adults and aggregated to allow for couple-level analyses. We conducted bivariate and multivariable Logistic regression to assess the factors that were independently associated with HIV infection among married couples.Results: Of the 664 couples, 6.4% ( n =42) were in HIV-discordant relationships; 5.8% ( n =39) were in concordant HIV-positive relationships while 87.8% ( n =583) were in concordant HIV-negative relationships. At the bivariate analysis, we found that individuals residing in a high HIV prevalence stratum had 4 times the odds of living as part of an HIV infected couple (odds ratio [OR]=4.29; 95% CI:2.95 6.25) than those in other lower HIV prevalence strata. Individuals who had been in at least three previous couple relationships were six times more likely to be part of an HIV infected couple (OR=6.25, 95% CI:4.11, 9.17) than their counterparts. After adjusting for potential cofounders, living in a high HIV prevalence stratum (Adjusted OR [AOR] =2.31, 95% CI: 1.52, 3.52) and being in a second (AOR=3.32, 95% CI: 2, 33, 4.70), third or higher order relationship (AOR=3.79, 95% CI: 2.29, 6.28) were associated with couple HIV infection. Individuals that had stayed together for six or more years had 28% odds of being part of an HIV infected couple (AOR = 0.28; 95%CI: 0.18, 0.43).Conclusion: The risk factors associated with HIV infection in married couples were living in a high HIV prevalence stratum and having a higher number of previous couple relationships. These findings suggest a need for pre-marital couples’ HIV testing to reduce on the number of relationships that form when one or both partners are already infected with HIV.

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Is Emtricitabine-Tenofovir Disoproxil Fumarate Pre-exposure Prophylaxis for the Prevention of Human Immunodeficiency Virus Infection Safer Than Aspirin?

Open Forum Infectious Diseases ◽

10.1093/ofid/ofv221 ◽

2016 ◽

Vol 3 (1) ◽

Cited By ~ 7

Author(s):

Noah Kojima ◽

Jeffrey D. Klausner

Keyword(s):

Human Immunodeficiency Virus ◽

Gastrointestinal Bleeding ◽

Hiv Infection ◽

Tenofovir Disoproxil Fumarate ◽

African Women ◽

Health Study ◽

Heterosexual Couples ◽

Preexposure Prophylaxis ◽

Immunodeficiency Virus ◽

Exposure Prophylaxis

Abstract Background. The safety and effectiveness studies of emtricitabine-tenofovir disoproxil fumarate (FTC-TDF) for human immunodeficiency virus (HIV) infection pre-exposure prophylaxis (PrEP) in men and women showed that daily use reduced the risk of HIV acquisition, but there still may concerns about safety. Methods. A narrative review was done in September 2015 comparing the 5 major studies on PrEP for HIV infection—Preexposure Prophylaxis Initiative (N = 2499; 3324 person-years), Partners Preexposure Prophylaxis (N = 4747; 7830 person-years), TDF2 (N = 1219; 1563 person-years), Preexposure Prophylaxis Trial for HIV Prevention among African Women (N = 2056; 1407 person-years), and Vaginal and Oral Interventions to Control the Epidemic (N = 4969; 5509 person-years)—and the 2 major studies on aspirin safety—Physicians' Health Study (N = 22 071; over 110 000 person-years) and the Women's Health Study (N = 39 876; approximately 400 000 person-years). The numbers needed to harm (NNH) were calculated for FTC-TDF for HIV infection PrEP and aspirin. Results. The NNH for FTC-TDF in men who have sex with men and transgender women was 114 for nausea and 96 for unintentional weight loss; in heterosexual couples, the NNH was 68 for moderate decreased absolute neutrophil count. For aspirin, the NNH was 909 for major gastrointestinal bleeding, 123 for any gastrointestinal bleeding, and 15 for any bleeding problems in men. In women, the NNH for easy bruising was 10. Conclusions. We conclude that FTC-TDF for PrEP for HIV infection favorably compares with aspirin in terms of user safety. Although long-term studies are needed, providers should feel reassured about the safety of short- and medium-term PrEP for HIV infection with FTC-TDF.

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Risk factors for concordant HIV infection in heterosexual couples in Trinidad

International Journal of STD & AIDS ◽

10.1258/0956462981921918 ◽

1998 ◽

Vol 9 (3) ◽

pp. 151-157 ◽

Cited By ~ 6

Author(s):

E M De Gourville ◽

D Mabey ◽

M Quigley ◽

N Jack ◽

B Mahabir

Keyword(s):

Risk Factors ◽

Hiv Infection ◽

Index Case ◽

Past History ◽

Clinical Status ◽

Sex Partners ◽

Heterosexual Couples ◽

Heterosexual Intercourse ◽

Increased Risk ◽

Index Cases

Summary: Risk factors for HIV infection in partners of HIV-seropositive index cases were investigated in a cross-sectional survey. Between September 1992 and April 1994 a total of 251 HIV-infected persons and 76 of their sexual partners were interviewed at the main sexually transmitted diseases (STDs) clinic in Trinidad. All participants gave signed consent and responded to a questionnaire. Sixty-four couples had risks for HIV infection through heterosexual intercourse only. However, many recruited sex partners (57/64) reported heterosexual intercourse with persons in addition to the index cases. Overall HIV concordance (both index case and partner HIV infected) was 45% in the couples. HIV concordance was not found to be related to the sexual practices within the studied unions nor to the clinical status of the index case. After allowing for confounding factors there was an increased risk for HIV concordance in couples in unions for 3.48; 95% CI 0.89-13.69, P =0.055), and in those in which sex partners had a past history of genital sores (adjusted for prostitution: OR 4.50; 95% CI 1.01-20.4). Interventions targeted at reducing high-risk sexual behaviour, prostitution and cocaine use could be beneficial in reducing the spread of STDs and HIV in Trinidad. 1 year (adjusted OR

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