scholarly journals Tolerogenic dendritic cell transfer ameliorates systemic lupus erythematosus in mice

Immunology ◽  
2019 ◽  
Vol 158 (4) ◽  
pp. 322-339 ◽  
Author(s):  
Samanta C. Funes ◽  
Mariana Ríos ◽  
Felipe Gómez‐Santander ◽  
Ayleen Fernández‐Fierro ◽  
María J. Altamirano‐Lagos ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Dendritic Cell ◽  
Lupus Erythematosus ◽  
Cell Transfer ◽  
Systemic Lupus ◽  
Tolerogenic Dendritic Cell

AB0480 Towards A Novel Tolerogenic Dendritic Cell Based Immunotherapy for Systemic Lupus Erythematosus

2014 ◽  
Vol 73 (Suppl 2) ◽  
pp. 966.2-966
Author(s):  
F.A. Vega ◽  
A. Torres ◽  
S. Iacobelli ◽  
A. Kalergis ◽  
C. Llanos
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Dendritic Cell ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Tolerogenic Dendritic Cell

scholarly journals Circulating Apoptotic Microparticles in Systemic Lupus Erythematosus Patients Drive the Activation of Dendritic Cell Subsets and Prime Neutrophils for NETosis

2016 ◽  
Vol 68 (2) ◽  
pp. 462-472 ◽  
Author(s):  
Jürgen Dieker ◽  
Jurjen Tel ◽  
Elmar Pieterse ◽  
Astrid Thielen ◽  
Nils Rother ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Dendritic Cell ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Dendritic Cell Subsets

The interplay of dendritic cell subsets in systemic lupus erythematosus

2002 ◽  
Vol 80 (5) ◽  
pp. 484-488 ◽  
Author(s):  
A Karolina Palucka ◽  
Jacques Banchereau ◽  
Patrick Blanco ◽  
Virginia Pascual
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Dendritic Cell ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Dendritic Cell Subsets

scholarly journals BDCA-2, a Novel Plasmacytoid Dendritic Cell–specific Type II C-type Lectin, Mediates Antigen Capture and Is a Potent Inhibitor of Interferon α/β Induction

2001 ◽  
Vol 194 (12) ◽  
pp. 1823-1834 ◽  
Author(s):  
Andrzej Dzionek ◽  
Yoshiaki Sohma ◽  
Jun Nagafune ◽  
Marina Cella ◽  
Marco Colonna ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Dendritic Cells ◽  
Monoclonal Antibodies ◽  
Dendritic Cell ◽  
Lupus Erythematosus ◽  
Plasmacytoid Dendritic Cell ◽  
Plasmacytoid Dendritic Cells ◽  
Interferon Α ◽  
Type Ii ◽  
Systemic Lupus

Plasmacytoid dendritic cells are present in lymphoid and nonlymphoid tissue and contribute substantially to both innate and adaptive immunity. Recently, we have described several monoclonal antibodies that recognize a plasmacytoid dendritic cell-specific antigen, which we have termed BDCA-2. Molecular cloning of BDCA-2 revealed that BDCA-2 is a novel type II C-type lectin, which shows 50.7% sequence identity at the amino acid level to its putative murine ortholog, the murine dendritic cell–associated C-type lectin 2. Anti–BDCA-2 monoclonal antibodies are rapidly internalized and efficiently presented to T cells, indicating that BDCA-2 could play a role in ligand internalization and presentation. Furthermore, ligation of BDCA-2 potently suppresses induction of interferon α/β production in plasmacytoid dendritic cells, presumably by a mechanism dependent on calcium mobilization and protein-tyrosine phosphorylation by src-family protein-tyrosine kinases. Inasmuch as production of interferon α/β by plasmacytoid dendritic cells is considered to be a major pathophysiological factor in systemic lupus erythematosus, triggering of BDCA-2 should be evaluated as therapeutic strategy for blocking production of interferon α/β in systemic lupus erythematosus patients.

scholarly journals AB0129 PCSK9 IS ASSOCIATED WITH DISEASE ACTIVITY AND IMPLICATED IN IMMUNE ACTIVATION IN SYSTEMIC LUPUS ERYTHEMATOSUS

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1365.1-1366
Author(s):  
A. Liu ◽  
M. Rahman ◽  
I. Hafström ◽  
S. Ajeganova ◽  
J. Frostegård
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Cardiovascular Disease ◽  
Dendritic Cell ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Ex Vivo ◽  
Human Peripheral Blood ◽  
Oxidized Ldl ◽  
Systemic Lupus ◽  
Dc Maturation

Background:LDL-levels are increased by Proprotein convertase subtilisin kexin 9 (PCSK9) which targets the LDL-receptor (LDLR). We reported that PCSK9 has immune modulatory properties in addition to LDL-lowering and ameliorates dendritic cell (DC) activation by oxidized LDL (OxLDL)1, which is abundant in atherosclerotic plaques. OxLDL is also raised and associated with cardiovascular disease (CVD) in SLE.1-3Objectives:We here investigate the role of PCSK9 in SLE both in a clinical context and in experimental ex vivo studies. The objective is to investigate if PCSK9 and its inhibition could be of relevance in SLE in addition to LDL-level related propertiesMethods:PCSK9-levels were determined by ELISA among SLE patients (n=109) and age- and sex-matched population-based controls (n=91). Common carotid intima-media thickness (IMT) and plaque occurrence were determined by B-mode ultrasound. Plaques were graded by echogenicity. Human peripheral blood monocytes from SLE patients or controls were differentiated into DCs. Effects of PCSK9 and its inhibition by silencing were studied.Results:PCSK9-levels were non-significantly higher among SLE-patients as compared to controls but associated significantly with SLE disease activity, as determined by SLAM (0.020) or SLEDAI (0.0178). There was no association between PCSK9-levels and atherosclerosis as determined by IMT, prevalence of plaques or echolucent (potentially vulnerable) plaques. PCSK9 levels were significantly associated with CVD among SLE-patients but not after adjustment for age.OxLDL induced PCSK9 in DCs and DC-maturation with increased expression of CD86 and HLA-DR. The effects were significantly stronger in DC from SLE patients than from controls. Silencing of PCSK9 abolished OxLDL-induced DC-maturation.Conclusion:PCSK9 is associated with disease activity in SLE. One underlying cause could be OxLDL, promoting DC-activation which depends on PCSK9. OxLDL induces PCSK9, an effect which is higher among SLE-patients.PCSK9 could play an unexpected immunological role in SLE and inhibition of PCSK9 could potentially play a role in disease amelioration, pending on clinical studies.References:[1]Liu A and Frostegard J. PCSK9 plays a novel immunological role in oxidized LDL-induced dendritic cell maturation and activation of T cells from human blood and atherosclerotic plaque.J Intern Med. 2018.[2]Frostegard J, Svenungsson E, Wu R, Gunnarsson I, Lundberg IE, Klareskog L, Horkko S and Witztum JL. Lipid peroxidation is enhanced in patients with systemic lupus erythematosus and is associated with arterial and renal disease manifestations.Arthritis Rheum. 2005;52:192-200.[3]Frostegard J. Immunity, atherosclerosis and cardiovascular disease.BMC Med. 2013;11:117.Disclosure of Interests:Anquan Liu: None declared, Mizanur Rahman: None declared, Ingiäld Hafström: None declared, Sofia Ajeganova: None declared, Johan Frostegård Grant/research support from: Unconditional competitive grant from Amgen, related only to PCSK9, not the topic of this abstract

scholarly journals Aberrant CD200/CD200R1 expression and function in systemic lupus erythematosus contributes to abnormal T-cell responsiveness and dendritic cell activity

2012 ◽  
Vol 14 (3) ◽  
pp. R123 ◽  
Author(s):  
Yang Li ◽  
Li-dan Zhao ◽  
Lu-sha Tong ◽  
Su-ning Qian ◽  
Yan Ren ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
T Cell ◽  
Dendritic Cell ◽  
Lupus Erythematosus ◽  
Cell Activity ◽  
Systemic Lupus ◽  
And Function

scholarly journals The Impact of Vitamin D on Dendritic Cell Function in Patients with Systemic Lupus Erythematosus

PLoS ONE ◽  
2010 ◽  
Vol 5 (2) ◽  
pp. e9193 ◽  
Author(s):  
Ilan Ben-Zvi ◽  
Cynthia Aranow ◽  
Meggan Mackay ◽  
Anfisa Stanevsky ◽  
Diane L. Kamen ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Vitamin D ◽  
Dendritic Cell ◽  
Lupus Erythematosus ◽  
Cell Function ◽  
Dendritic Cell Function ◽  
Systemic Lupus ◽  
The Impact

scholarly journals Dendritic cell-associated B7-H3 suppresses the production of autoantibodies and renal inflammation in a mouse model of systemic lupus erythematosus

2019 ◽  
Vol 10 (6) ◽  
Author(s):  
Xu Zheng ◽  
Ze Xiu Xiao ◽  
Li Hu ◽  
Xuan Fang ◽  
Liqun Luo ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Dendritic Cell ◽  
Mouse Model ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Renal Inflammation
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