scholarly journals The blockade of CC chemokine receptor type 1 influences the level of nociceptive factors and enhances opioid analgesic potency in a rat model of neuropathic pain

Immunology ◽  
2020 ◽  
Vol 159 (4) ◽  
pp. 413-428 ◽  
Author(s):  
Katarzyna Pawlik ◽  
Anna Piotrowska ◽  
Klaudia Kwiatkowski ◽  
Katarzyna Ciapała ◽  
Katarzyna Popiolek‐Barczyk ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Chemokine Receptor ◽  
Rat Model ◽  
Opioid Analgesic ◽  
Receptor Type ◽  
Cc Chemokine ◽  
Analgesic Potency

scholarly journals Blockade of CC Chemokine Receptor Type 3 Diminishes Pain and Enhances Opioid Analgesic Potency in a Model of Neuropathic Pain

2021 ◽  
Vol 12 ◽  
Author(s):  
Katarzyna Pawlik ◽  
Agata Ciechanowska ◽  
Katarzyna Ciapała ◽  
Ewelina Rojewska ◽  
Wioletta Makuch ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Neuropathic Pain ◽  
Chemokine Receptor ◽  
Pain Treatment ◽  
Opioid Analgesic ◽  
Receptor Type ◽  
Clinical Issue ◽  
Cc Chemokine ◽  
Type 3

Neuropathic pain is a serious clinical issue, and its treatment remains a challenge in contemporary medicine. Thus, dynamic development in the area of animal and clinical studies has been observed. The mechanisms of neuropathic pain are still not fully understood; therefore, studies investigating these mechanisms are extremely important. However, much evidence indicates that changes in the activation and infiltration of immune cells cause the release of pronociceptive cytokines and contribute to neuropathic pain development and maintenance. Moreover, these changes are associated with low efficacy of opioids used to treat neuropathy. To date, the role of CC chemokine receptor type 3 (CCR3) in nociception has not been studied. Similarly, little is known about its endogenous ligands (C-C motif ligand; CCL), namely, CCL5, CCL7, CCL11, CCL24, CCL26, and CCL28. Our research showed that the development of hypersensitivity in rats following chronic constriction injury (CCI) of the sciatic nerve is associated with upregulation of CCL7 and CCL11 in the spinal cord and dorsal root ganglia (DRG). Moreover, our results provide the first evidence that single and repeated intrathecal administration of the CCR3 antagonist SB328437 diminishes mechanical and thermal hypersensitivity. Additionally, repeated administration enhances the analgesic properties of morphine and buprenorphine following nerve injury. Simultaneously, the injection of SB328437 reduces the protein levels of some pronociceptive cytokines, such as IL-6, CCL7, and CCL11, in parallel with a reduction in the activation and influx of GFAP-, CD4- and MPO-positive cells in the spinal cord and/or DRG. Moreover, we have shown for the first time that an inhibitor of myeloperoxidase-4-aminobenzoic hydrazide may relieve pain and simultaneously enhance morphine and buprenorphine efficacy. The obtained results indicate the important role of CCR3 and its modulation in neuropathic pain treatment and suggest that it represents an interesting target for future investigations.

The importance of chemokines in neuropathic pain development and opioid analgesic potency

2018 ◽  
Vol 70 (4) ◽  
pp. 821-830 ◽  
Author(s):  
Klaudia Kwiatkowski ◽  
Joanna Mika
Keyword(s):  
Neuropathic Pain ◽  
Opioid Analgesic ◽  
Analgesic Potency

Restriction of HIV Type 1 Infection in Macrophages Heterozygous for a Deletion in the CC-Chemokine Receptor 5 Gene

1999 ◽  
Vol 15 (16) ◽  
pp. 1441-1452 ◽  
Author(s):  
Lucia Ometto ◽  
Marisa Zanchetta ◽  
Anna Cabrelle ◽  
Giovanni Esposito ◽  
Monica Mainardi ◽  
...  
Keyword(s):  
Chemokine Receptor ◽  
Cc Chemokine ◽  
Hiv Type 1 ◽  
Cc Chemokine Receptor 5 ◽  
Chemokine Receptor 5

scholarly journals Depletion of regulatory T cells by targeting CC chemokine receptor type 4 with mogamulizumab

2015 ◽  
Vol 4 (7) ◽  
pp. e1011524 ◽  
Author(s):  
Xiao Ni ◽  
Timothy Langridge ◽  
Madeleine Duvic
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Chemokine Receptor ◽  
Receptor Type ◽  
Cc Chemokine

scholarly journals Therapeutic Effect of C-C Chemokine Receptor Type 1 (CCR1) Antagonist BX471 on Allergic Rhinitis

2020 ◽  
Vol Volume 13 ◽  
pp. 343-356
Author(s):  
Suoyi Feng ◽  
Longzhu Ju ◽  
Ziqi Shao ◽  
Mark Grzanna ◽  
Lu Jia ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Therapeutic Effect ◽  
Chemokine Receptor ◽  
Receptor Type ◽  
Ccr1 Antagonist

CCR4 antagonist (C021) influences the level of nociceptive factors and enhances the analgesic potency of morphine in a rat model of neuropathic pain

2020 ◽  
Vol 880 ◽  
pp. 173166 ◽  
Author(s):  
Joanna Bogacka ◽  
Katarzyna Popiolek-Barczyk ◽  
Katarzyna Pawlik ◽  
Agata Ciechanowska ◽  
Wioletta Makuch ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Rat Model ◽  
Analgesic Potency

scholarly journals In silico prediction of the functional and structural consequences of the non-synonymous single nucleotide polymorphism A122V in bovine CXC chemokine receptor type 1

2020 ◽  
Vol 80 (1) ◽  
pp. 39-46
Author(s):  
A. F. Guzzi ◽  
F. S. L. Oliveira ◽  
M. M. S. Amaro ◽  
P. F. Tavares-Filho ◽  
J. E. Gabriel
Keyword(s):  
Amino Acid ◽  
Chemokine Receptor ◽  
In Silico ◽  
Alpha Helix ◽  
Amino Acid Sequences ◽  
Receptor Type ◽  
Amino Acid Residues ◽  
Causal Polymorphism ◽  
Cxc Chemokine

Abstract The current study aimed to assess whether the A122V causal polymorphism promotes alterations in the functional and structural proprieties of the CXC chemokine receptor type 1 protein (CXCR1) of cattle Bos taurus by in silico analyses. Two amino acid sequences of bovine CXCR1 was selected from database UniProtKB/Swiss-Prot: a) non-polymorphic sequence (A7KWG0) with alanine (A) at position 122, and b) polymorphic sequence harboring the A122V polymorphism, substituting alanine by valine (V) at same position. CXCR1 sequences were submitted as input to different Bioinformatics’ tools to examine the effects of this polymorphism on functional and structural stabilities, to predict eventual alterations in the 3-D structural modeling, and to estimate the quality and accuracy of the predictive models. The A122V polymorphism exerted tolerable and non-deleterious effects on the polymorphic CXCR1, and the predictive structural model for polymorphic CXCR1 revealed an alpha helix spatial structure typical of a receptor transmembrane polypeptide. Although higher variations in the distances between pairs of amino acid residues at target-positions are detected in the polymorphic CXCR1 protein, more than 97% of the amino acid residues in both models were located in favored and allowed conformational regions in Ramachandran plots. Evidences has supported that the A122V polymorphism in the CXCR1 protein is associated with increased clinical mastitis incidence in dairy cows. Thus, the findings described herein prove that the replacement of the alanine by valine amino acids provokes local conformational changes in the A122V-harboring CXCR1 protein, which could directly affect its post-translational folding mechanisms and biological functionality.

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