<p>Therapeutic Effect of C-C Chemokine Receptor Type 1 (CCR1) Antagonist BX471 on Allergic Rhinitis</p>

Abstract The current study aimed to assess whether the A122V causal polymorphism promotes alterations in the functional and structural proprieties of the CXC chemokine receptor type 1 protein (CXCR1) of cattle Bos taurus by in silico analyses. Two amino acid sequences of bovine CXCR1 was selected from database UniProtKB/Swiss-Prot: a) non-polymorphic sequence (A7KWG0) with alanine (A) at position 122, and b) polymorphic sequence harboring the A122V polymorphism, substituting alanine by valine (V) at same position. CXCR1 sequences were submitted as input to different Bioinformatics’ tools to examine the effects of this polymorphism on functional and structural stabilities, to predict eventual alterations in the 3-D structural modeling, and to estimate the quality and accuracy of the predictive models. The A122V polymorphism exerted tolerable and non-deleterious effects on the polymorphic CXCR1, and the predictive structural model for polymorphic CXCR1 revealed an alpha helix spatial structure typical of a receptor transmembrane polypeptide. Although higher variations in the distances between pairs of amino acid residues at target-positions are detected in the polymorphic CXCR1 protein, more than 97% of the amino acid residues in both models were located in favored and allowed conformational regions in Ramachandran plots. Evidences has supported that the A122V polymorphism in the CXCR1 protein is associated with increased clinical mastitis incidence in dairy cows. Thus, the findings described herein prove that the replacement of the alanine by valine amino acids provokes local conformational changes in the A122V-harboring CXCR1 protein, which could directly affect its post-translational folding mechanisms and biological functionality.

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Therapeutic Effect of Soluble Complement Receptor Type 1 in Xenotransplantation

Xenotransplantation ◽

10.1007/978-3-642-60572-7_33 ◽

1997 ◽

pp. 437-455 ◽

Cited By ~ 1

Author(s):

H. C. Marsh ◽

U. S. Ryan

Keyword(s):

Therapeutic Effect ◽

Receptor Type ◽

Complement Receptor ◽

Complement Receptor Type ◽

Complement Receptor Type 1

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C-C chemokine receptor type 1 mediates osteopontin-promoted metastasis in hepatocellular carcinoma

Cancer Science ◽

10.1111/cas.13487 ◽

2018 ◽

Vol 109 (3) ◽

pp. 710-723 ◽

Cited By ~ 4

Author(s):

Ying Zhu ◽

Xiao-Mei Gao ◽

Jing Yang ◽

Da Xu ◽

Yu Zhang ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Chemokine Receptor ◽

Receptor Type

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Catenarin Prevents Type 1 Diabetes in Nonobese Diabetic Mice via Inhibition of Leukocyte Migration Involving the MEK6/p38 and MEK7/JNK Pathways

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2012/982396 ◽

2012 ◽

Vol 2012 ◽

pp. 1-13 ◽

Cited By ~ 2

Author(s):

Ming-Yi Shen ◽

Yu-Ping Lin ◽

Bei-Chang Yang ◽

Yu-Song Jang ◽

Chih-Kang Chiang ◽

...

Keyword(s):

Type 1 Diabetes ◽

Chemokine Receptor ◽

Cell Loss ◽

Leukocyte Migration ◽

Receptor Type ◽

Mechanistic Study ◽

Diabetic Mice ◽

Nonobese Diabetic ◽

Nonobese Diabetic Mice

Inflammation contributes to leukocyte migration, termed insulitis, andβ-cell loss in type 1 diabetes (T1D). Naturally occurring anthraquinones are claimed as anti-inflammatory compounds; however, their actions are not clear. This study aimed to investigate the effect and mechanism of catenarin on the inflammatory disease, T1D. Catenarin and/or its anthraquinone analogs dose-dependently suppressed C-X-C chemokine receptor type 4 (CXCR4)- and C-C chemokine receptor type 5 (CCR5)-implicated chemotaxis in leukocytes. Catenarin, the most potent anthraquinone tested in the study, prevented T1D in nonobese diabetic mice. Mechanistic study showed that catenarin did not act on the expression of CCR5 and CXCR4. On the contrary, catenarin inhibited CCR5- and CXCR4-mediated chemotaxis via the reduction of the phosphorylation of mitogen-activated protein kinases (p38 and JNK) and their upstream kinases (MKK6 and MKK7), and calcium mobilization. Overall, the data demonstrate the preventive effect and molecular mechanism of action of catenarin on T1D, suggesting its novel use as a prophylactic agent in T1D.

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Abstract 1964: C-C chemokine receptor type 1 is a prognostic indicator in ovarian cancer

10.1158/1538-7445.am2019-1964 ◽

2019 ◽

Author(s):

Anita M. Chanana ◽

Venkatesh Krishnan ◽

Supreeti Tallapragada ◽

Oliver Dorigo

Keyword(s):

Ovarian Cancer ◽

Chemokine Receptor ◽

Prognostic Indicator ◽

Receptor Type

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Abstract 1964: C-C chemokine receptor type 1 is a prognostic indicator in ovarian cancer

10.1158/1538-7445.sabcs18-1964 ◽

2019 ◽

Author(s):

Anita M. Chanana ◽

Venkatesh Krishnan ◽

Supreeti Tallapragada ◽

Oliver Dorigo

Keyword(s):

Ovarian Cancer ◽

Chemokine Receptor ◽

Prognostic Indicator ◽

Receptor Type

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Identification and Analysis of Key Genes Associated with Ulcerative Colitis by Integrated Bioinformatics Methods

10.21203/rs.3.rs-1019392/v1 ◽

2021 ◽

Author(s):

Xingyu Yu ◽

Jinjie Li ◽

Hongci Chen ◽

Xingmeng Chen ◽

Yu Xiang

Keyword(s):

Ulcerative Colitis ◽

Signaling Pathway ◽

Protein Interaction ◽

Chemokine Receptor ◽

Cytokine Receptor ◽

Receptor Type ◽

Receptor Interaction ◽

Potential Candidate ◽

Hub Genes

Abstract Background: Ulcerative colitis (UC) is a prevalent inflammatory bowel disease of the colonic mucosa. The exact mechanism of the disease still remains unclear. Here we tried to explore new biomarkers and potential therapeutic targets in UC through adopting integrated bioinformatics tools.Results: By performing DEGs analysis, 59 upregulated and 39 downregulated DEGs were successfully identified from GSE3365, respectively. And they were mainly enriched in the terms of Cytokine-cytokine receptor interaction,Viral protein interaction with cytokine and cytokine receptor,Pantothenate and CoA biosynthesis,IL-17 signaling pathway and Chemokine signaling pathway. Based on the data of protein–protein interaction (PPI), the top 10 hub genes were ranked, including Growth-regulated alpha protein (CXCL1), C-C motif chemokine 2 (CCL2), C-X-C chemokine receptor type 1 (CXCR1), Low affinity immunoglobulin gamma Fc region receptor III-B (FCGR3B), C-X-C chemokine receptor type 2 (CXCR2), Prostaglandin G/H synthase 2 (PTGS2), Triggering receptor expressed on myeloid cells 1 (TREM1), Interleukin-1 receptor type 1 (IL1R1), fMet-Leu-Phe receptor (FPR1), and Band 3 anion transport protein (SLC4A1).What’s more, the results of correlation analysis demonstrated that there was a positive correlation between the 10 hub DEGs.Conclusion: Ten DEGs were identified as potential candidate diagnostic biomarkers for patients with UC in present study. However, further experiments are needed to confirm the functional pathways and hub genes associated with UC.

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