Comparison of wound healing and patient comfort in partial‐thickness burn wounds treated with SUPRATHEL and epicte hydro wound dressings

(1) Background: Wounds with damages to the subcutaneous are difficult to regenerate because of the tissue damages and complications such as bacterial infection. (2) Methods: In this study, we created burn wounds on pigs and investigated the efficacy of three biomaterials: polycaprolactone-gelatin-silver membrane (PCLGelAg) and two commercial burn dressings, Aquacel® Ag and UrgoTulTM silver sulfadiazine. In vitro long-term antibacterial property and in vivo wound healing performance were investigated. Agar diffusion assays were employed to evaluate bacterial inhibition at different time intervals. Minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and time-kill assays were used to compare antibacterial strength among samples. Second-degree burn wounds in the pig model were designed to evaluate the efficiency of all dressings in supporting the wound healing process. (3) Results: The results showed that PCLGelAg membrane was the most effective in killing both Gram-positive and Gram-negative bacteria bacteria with the lowest MBC value. All three dressings (PCLGelAg, Aquacel, and UrgoTul) exhibited bactericidal effect during the first 24 h, supported wound healing as well as prevented infection and inflammation. (4) Conclusions: The results suggest that the PCLGelAg membrane is a practical solution for the treatment of severe burn injury and other infection-related skin complications.

Download Full-text

Fabrication, characterization and evaluation of the efficacy of gelatin/hyaluronic acid microporous scaffolds suffused with aloe-vera in a rat burn model

Journal of Biomaterials Applications ◽

10.1177/08853282211061821 ◽

2021 ◽

pp. 088532822110618

Author(s):

Lalita Mehra ◽

Smritee Mehra ◽

Nidhi Tiwari ◽

Thakuri Singh ◽

Harish Rawat ◽

...

Keyword(s):

Hyaluronic Acid ◽

Growth Factor ◽

Aloe Vera ◽

Gamma Scintigraphy ◽

Gravimetric Analysis ◽

Burn Wounds ◽

Partial Thickness ◽

Partial Thickness Burn

Burn induced injuries are commonly encountered in civilian and military settings, leading to severe morbidity and mortality. Objective of this study was to construct microporous bioactive scaffolds of gelatin-hyaluronic acid suffused with aloe-vera gel (Gela/HA/AvG), and to evaluate their efficacy in healing partial-thickness burn wounds. Scaffolds were characterized using Fourier transform-infrared spectroscopy, Scanning electron microscopy, and Thermo-gravimetric analysis to understand intermolecular interactions and morphological characteristics. In-vitro fluid uptake ability and hemolytic index of test scaffolds were also determined. In-vitro collagenase digestion was done to assess biodegradability of scaffolds. Wound retraction studies were carried out in Sprague Dawley rats inflicted with partial-thickness burn wounds to assess and compare efficacy of optimized scaffolds with respect to negative and positive control groups. In-vivo gamma scintigraphy using Technetium-99m labeled Immunoglobulin-G ( 99m Tc-IgG) as imaging agent was also performed to validate efficacy results. Histological and immunohistochemical comparison between groups was also made. Scaffolds exhibited mircoporous structure, with pore size getting reduced from 41.3 ± 4.3 µm to 30.49 ± 5.7 µm when gelatin conc. was varied from 1% to 5%. Optimized test scaffolds showed sustained in-vitro swelling behavior, were biodegradable and showed hemolytic index in range of 2.4–4.3%. Wound retraction study along with in-vivo gamma scintigraphy indicated that Gela/HA/AvG scaffolds were not only able to reduce local inflammation faster but also accelerated dermis regeneration. Immunohistochemical analysis, in terms of expression levels of epidermal growth factor and fibroblast growth factor-2 also corroborated in-vivo efficacy findings. Gela/HA/AvG scaffolds, therefore, can potentially be developed into an effective dermal regeneration template for partial-thickness burn wounds.

Download Full-text

Preparation, biocompatibility, and wound healing effects of O-carboxymethyl chitosan nonwoven fabrics in partial-thickness burn model

Carbohydrate Polymers ◽

10.1016/j.carbpol.2021.119032 ◽

2021 ◽

pp. 119032

Author(s):

Zhiwen Jiang ◽

Lulu Li ◽

Hui Li ◽

Lixin Xia ◽

Huiwen Hu ◽

...

Keyword(s):

Wound Healing ◽

Carboxymethyl Chitosan ◽

Nonwoven Fabrics ◽

Partial Thickness ◽

Partial Thickness Burn

Download Full-text

Comparison of efficacy of silver-nanoparticle gel, nano-silver-foam and collagen dressings in treatment of partial thickness burn wounds

Burns ◽

10.1016/j.burns.2019.07.019 ◽

2019 ◽

Vol 45 (8) ◽

pp. 1888-1894 ◽

Cited By ~ 6

Author(s):

Miying Erring ◽

Sunil Gaba ◽

Subair Mohsina ◽

Satyaswarup Tripathy ◽

Ramesh Kumar Sharma

Keyword(s):

Silver Nanoparticle ◽

Nano Silver ◽

Burn Wounds ◽

Partial Thickness ◽

Partial Thickness Burn

Download Full-text

Solanum incanum extract enhances wound healing and tissue regeneration in burn mice model

Bangladesh Journal of Pharmacology ◽

10.3329/bjp.v14i2.40098 ◽

2019 ◽

Vol 14 (2) ◽

pp. 101-106

Author(s):

Zainab Qureshi ◽

Taous Khan ◽

Abdul Jabbar Shah ◽

Fazli Wahid

Keyword(s):

Wound Healing ◽

Tissue Regeneration ◽

Histological Analysis ◽

Negative Control ◽

Wound Contraction ◽

Mice Model ◽

Wound Area ◽

Solanum Incanum ◽

Partial Thickness ◽

Partial Thickness Burn

This study was conducted to evaluate the topical efficacy of Solanum incanum for the treatment of partial-thickness burn in mice model. Mice were treated with topical ointment of S. incanum three times daily for 14 days. The wound healing was observed through wound contraction and histological parameters. The group treated with S. incanum ointment showed 81% reduction in wound area as compared to negative control where wound area reduced to 22%. The histological analysis further confirmed that ointment favors the tissue regeneration and reepithelization thus heal wound rapidly as com-pared to other groups. In conclusion, S. incanum extract enhances wound healing and tissue regeneration.

Download Full-text

The Efficacy of Five Different Wound Dressings on Some Histological Parameters in Children With Partial-Thickness Burns

Journal of Burn Care & Research ◽

10.1093/jbcr/iraa063 ◽

2020 ◽

Vol 41 (6) ◽

pp. 1179-1187 ◽

Cited By ~ 1

Author(s):

Birsen Harma ◽

Mehmet Gül ◽

Mehmet Demircan

Keyword(s):

Stratum Corneum ◽

Gold Standard ◽

Statistical Significance ◽

Healing Process ◽

Total Body Surface Area ◽

Wound Dressings ◽

Control Group ◽

Burn Wounds ◽

Partial Thickness ◽

Partial Thickness Burns

Abstract An ideal dressing should ensure that the wound remains moist with exudates but not macerated. Currently, there is no dressing available to suit all wounds, at all stages of the healing process. Although silver-containing dressings are the gold standard for burn wound care, few high-level trials have been completed comparing the clinical utilities of these dressings. In our study, five different types of wound dressings: carboxymethyl cellulose hydrofiber dressing with ionized silver (CMCH-Ag), polyethylene-polyethylene terephthalate aqua fiber dressing with elementary silver (PPAF-Ag), calcium alginate (CA), calcium + zinc alginate (CZA), and 0.2% nitrofurazone-embedded (NF) gauze dressings were compared in regard to histopathological parameters. Children aged between 0 and 18 years with small or middle-sized partial-thickness burns that affected less than 30% of the total body surface area were included in this study. The study groups (CMCH-Ag, PPAF-Ag, CA, and CZA) and the control group (NF) were randomly attained. Wound healing was evaluated by punch biopsies on the 21st day. The thickness of the stratum corneum and the epithelium, the number of papillae, and the papillary length were calculated and compared. The histological parameters of healing, except the stratum corneum thickness, did not show any statistical significance among the groups (P > .05). The dressings that included silver, calcium, or zinc showed useful and similar effects in noninfective burn wounds when compared with nitrofurazone-only dressings. Thus, it may be concluded that silver-containing wound dressings should not be considered as the gold standard in noninfective partial-thickness burn wounds in children.

Download Full-text