Rapid and Continuous Increases in Incidence Rates of Basal Cell Carcinoma in the Southeast Netherlands Since 1973

In contrast to the well-established association between ultraviolet radiation (UVR) exposure and skin cancers, the relationship between UVR and uveal malignant melanoma (UM) remains controversial. To address this controversy, we evaluated the incidence rates of cutaneous malignancies in the eyelids as a proxy for UVR exposure in the ocular region using a population-based cancer registry. Overall, 74,053 cases of eyelid basal cell carcinoma (BCC) and 7890 cases of melanoma over a 26-year period (1982–2007) were analyzed. The incidence of eyelid basal cell carcinoma and uveal melanoma remained stable, whereas other cutaneous areas demonstrated an increase in the rates. A comparability test demonstrated that BCC incidence trends were significantly different between the eyelid versus both chronically exposed (males p = 0.001; females p = 0.01) and intermittently exposed skin (males and females, p = 0.0002), as well as the skin of the face (males p = 0.002; females p = 0.02). Similarly, melanoma trends were significantly different between the UM group versus both chronically exposed cutaneous melanoma (CM) (males p = 0.001; females p = 0.04) and intermittently exposed CM (males p = 0.005), as well as facial skin CM (males and females p = 0.0002). The discrepancy of cancer incidence between tumors in the peri-ocular region versus the rest of the body suggests that the peri-ocular region might have a different or unique exposure pattern to ultraviolet radiation.

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Incidence of Basal Cell Carcinoma in Cohort of Mayak Workers

Medical Radiology and radiation safety ◽

10.12737/1024-6177-2021-66-5-91-94 ◽

2021 ◽

Vol 66 (5) ◽

pp. 91-94

Author(s):

M. Bannikova ◽

T. Azizova

Keyword(s):

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Incidence Rate ◽

Basal Cell ◽

Linear Trend ◽

Incidence Rates ◽

Study Cohort ◽

Absolute Growth ◽

Study Population ◽

Males And Females

Results: To estimate incidence rates for basal cell carcinoma (BSC) following chronic occupational radiation exposure. Conclusion:The study cohort included 22,377 workers (25.4 % of females) of the nuclear production facility, Mayak Production Association (PA), who had been hired in 1948–1982. Gamma doses of external exposure were provided by the Mayak Workers Dosimetry System – 2013 (MWDS–2013). The cohort was followed up until 31.12.2018. Results: By the end of the follow-up period 293 BSC cases were registered in the study cohort. BSC incidence rates significantly increased with increasing attained age of workers. The highest BSC incidence rate was observed in the age group above 70 years, both for males and females. The study found a significant increasing linear trend for standardized incidence rates for both males and females; approximation confidence factors were R2 = 0.82 and R2 = 0.95, respectively. The majority of BSC cases in the study cohort were registered in 1994–2018 (71.12 % in males and 81.13 % in females). The component analysis demonstrated that the absolute growth in the BSC incidence rate in both males and females was due to changes in the age structure of the study population and the risk of the disease. Conclussion: BSC incidence rates were significantly higher in males externally exposed to gamma rays at cumulative skin absorbed doses 0.2–0.5 Gy, 0.5–1.0 Gy and above 1.0 Gy compared to those exposed at doses below 0.1 Gy. In females the corresponding differences were non-significant.

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Trends in basal cell carcinoma incidence rates: a 16-year retrospective study of a population in central Poland

Advances in Dermatology and Allergology ◽

10.5114/ada.2018.73164 ◽

2018 ◽

Vol 35 (1) ◽

pp. 47-52 ◽

Cited By ~ 1

Author(s):

Magdalena Ciążyńska ◽

Joanna Narbutt ◽

Anna Woźniacka ◽

Aleksandra Lesiak

Keyword(s):

Retrospective Study ◽

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Incidence Rates ◽

Central Poland

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Trends in Basal Cell Carcinoma Incidence Rates: A 37-Year Dutch Observational Study

Journal of Investigative Dermatology ◽

10.1038/jid.2012.431 ◽

2013 ◽

Vol 133 (4) ◽

pp. 913-918 ◽

Cited By ~ 75

Author(s):

Sophie C. Flohil ◽

Inge Seubring ◽

Michelle M. van Rossum ◽

Jan-Willem W. Coebergh ◽

Esther de Vries ◽

...

Keyword(s):

Basal Cell Carcinoma ◽

Observational Study ◽

Cell Carcinoma ◽

Basal Cell ◽

Incidence Rates

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Metastatic Basal Cell Carcinoma: A Rare Manifestation of a Common Disease

Case Reports in Medicine ◽

10.1155/2017/8929745 ◽

2017 ◽

Vol 2017 ◽

pp. 1-4 ◽

Cited By ~ 6

Author(s):

Paola Piva de Freitas ◽

César Galusni Senna ◽

Mayara Tabai ◽

Carlos Takahiro Chone ◽

Albina Altemani

Keyword(s):

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Incidence Rates ◽

Common Disease ◽

Submandibular Region ◽

Positron Emission ◽

High Prevalence ◽

Metastatic Basal Cell Carcinoma ◽

Level I

Introduction. Basal cell carcinoma (BCC) is considered the most common malignancy in Caucasians. It constituted about 80% of all nonmelanoma skin tumors and, despite its high prevalence, is an extremely rare occurrence of metastases, with incidence rates varying from 0.0028% to 0.55%.Case Report. A 58-year-old male patient with BCC on the left nasolabial sulcus for 17 years, reporting 3 previous excisions, evolved with local recurrence. A new procedure was performed, and anatomopathological study confirmed sclerosing BCC. Seven months later, he presented with a mass in the left submandibular region. Combined positron-emission tomography and computed tomography (PET-CT) showed cervical hypercaptation in the left cervical level I and vertebral body of L5. Excision of the cervical lesion was performed with diagnosis of sclerosing BCC compromising the submandibular gland. Biopsy of the lumbar lesion was found to be compatible with bone metastasis.Conclusion. BCC represents a very common entity, and the presence of metastasis, although infrequent, must be proposed because of the greater morbidity and mortality of this complication. This case shows the importance of early diagnosis and intervention in BCC as a way to avoid unfavorable outcomes.

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Ultrastructure of Mouse Basal Cell Carcinoma Exhibiting Sebaceous Differentiation

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s1431927600003214 ◽

1980 ◽

Vol 38 ◽

pp. 738-739

Author(s):

Victoria L. Wade ◽

Winslow G. Sheldon ◽

James W. Townsend ◽

William Allaben

Keyword(s):

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Topical Application ◽

Basal Cell ◽

Sebaceous Gland ◽

Rats And Mice ◽

Mixed Tumors

Sebaceous gland tumors and other tumors exhibiting sebaceous differentiation have been described in humans (1,2,3). Tumors of the sebaceous gland can be induced in rats and mice following topical application of carcinogens (4), but spontaneous mixed tumors of basal cell origin rarely occur in mice.

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