Incidence of Basal Cell Carcinoma in Cohort of Mayak Workers

Results: To estimate incidence rates for basal cell carcinoma (BSC) following chronic occupational radiation exposure. Conclusion:The study cohort included 22,377 workers (25.4 % of females) of the nuclear production facility, Mayak Production Association (PA), who had been hired in 1948–1982. Gamma doses of external exposure were provided by the Mayak Workers Dosimetry System – 2013 (MWDS–2013). The cohort was followed up until 31.12.2018. Results: By the end of the follow-up period 293 BSC cases were registered in the study cohort. BSC incidence rates significantly increased with increasing attained age of workers. The highest BSC incidence rate was observed in the age group above 70 years, both for males and females. The study found a significant increasing linear trend for standardized incidence rates for both males and females; approximation confidence factors were R2 = 0.82 and R2 = 0.95, respectively. The majority of BSC cases in the study cohort were registered in 1994–2018 (71.12 % in males and 81.13 % in females). The component analysis demonstrated that the absolute growth in the BSC incidence rate in both males and females was due to changes in the age structure of the study population and the risk of the disease. Conclussion: BSC incidence rates were significantly higher in males externally exposed to gamma rays at cumulative skin absorbed doses 0.2–0.5 Gy, 0.5–1.0 Gy and above 1.0 Gy compared to those exposed at doses below 0.1 Gy. In females the corresponding differences were non-significant.

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Changes in Ultraviolet Radiation Exposure to the Ocular Region: A Population-Based Study

Cancers ◽

10.3390/cancers11050719 ◽

2019 ◽

Vol 11 (5) ◽

pp. 719 ◽

Cited By ~ 2

Author(s):

Ezekiel Weis ◽

Sebastian Q. Vrouwe ◽

David B. LeBaron ◽

Matthew B. Parliament ◽

Jerry Shields ◽

...

Keyword(s):

Basal Cell Carcinoma ◽

Ultraviolet Radiation ◽

Cell Carcinoma ◽

Basal Cell ◽

Group Versus ◽

Population Based ◽

Incidence Rates ◽

The Body ◽

Incidence Trends ◽

Males And Females

In contrast to the well-established association between ultraviolet radiation (UVR) exposure and skin cancers, the relationship between UVR and uveal malignant melanoma (UM) remains controversial. To address this controversy, we evaluated the incidence rates of cutaneous malignancies in the eyelids as a proxy for UVR exposure in the ocular region using a population-based cancer registry. Overall, 74,053 cases of eyelid basal cell carcinoma (BCC) and 7890 cases of melanoma over a 26-year period (1982–2007) were analyzed. The incidence of eyelid basal cell carcinoma and uveal melanoma remained stable, whereas other cutaneous areas demonstrated an increase in the rates. A comparability test demonstrated that BCC incidence trends were significantly different between the eyelid versus both chronically exposed (males p = 0.001; females p = 0.01) and intermittently exposed skin (males and females, p = 0.0002), as well as the skin of the face (males p = 0.002; females p = 0.02). Similarly, melanoma trends were significantly different between the UM group versus both chronically exposed cutaneous melanoma (CM) (males p = 0.001; females p = 0.04) and intermittently exposed CM (males p = 0.005), as well as facial skin CM (males and females p = 0.0002). The discrepancy of cancer incidence between tumors in the peri-ocular region versus the rest of the body suggests that the peri-ocular region might have a different or unique exposure pattern to ultraviolet radiation.

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Basal cell carcinoma of the maxillofacial region: site distribution and incidence rates in Arab/Jordanians, 1991 to 2000

Journal of Oral and Maxillofacial Surgery ◽

10.1016/j.joms.2003.04.009 ◽

2004 ◽

Vol 62 (2) ◽

pp. 145-149 ◽

Cited By ~ 4

Author(s):

Ma’amon A Rawashdeh ◽

Ismail Matalka

Keyword(s):

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Incidence Rates ◽

Maxillofacial Region ◽

Site Distribution

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Basal Cell Carcinoma: 10 Years of Experience

Journal of Skin Cancer ◽

10.1155/2011/476362 ◽

2011 ◽

Vol 2011 ◽

pp. 1-5 ◽

Cited By ~ 20

Author(s):

Emanuele Cigna ◽

Mauro Tarallo ◽

Michele Maruccia ◽

Valentina Sorvillo ◽

Alessia Pollastrini ◽

...

Keyword(s):

High Risk ◽

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Basal Cell ◽

Tumor Size ◽

Study Cohort ◽

Tumor Characteristics ◽

Complete Excision ◽

Upper And Lower Extremities

Introduction. Basal cell carcinoma (BCC) is a locally invasive malignant epidermal tumour. Incidence is increasing by 10% per year; incidence of metastases is minimal, but relapses are frequent (40%–50%). The complete excision of the BCC allows reduction of relapse.Materials and Methods. The study cohort consists of 1123 patients underwent surgery for basal cell carcinoma between 1999 and 2009. Patient and tumor characteristics recorded are: age; gender; localization (head and neck, trunk, and upper and lower extremities), tumor size, excisional margins adopted, and relapses.Results. The study considered a group of 1123 patients affected by basal cell carcinoma. Relapses occurred in 30 cases (2,67%), 27 out of 30 relapses occurred in noble areas, where peripheral margin was <3 mm. Incompletely excised basal cell carcinoma occurred in 21 patients (1,87%) and were treated with an additional excision.Discussion. Although guidelines indicate 3 mm peripheral margin of excision in BCC <2 cm, in our experience, a margin of less than 5 mm results in a high risk of incomplete excisions.

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A A Rare Case of a Metastatic Basal Cell Carcinoma

European Journal of Medical and Health Sciences ◽

10.24018/ejmed.2020.2.5.522 ◽

2020 ◽

Vol 2 (5) ◽

Author(s):

Hiba Chaudhry ◽

Dimitrios Doumpiotis

Keyword(s):

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Incidence Rate ◽

Basal Cell ◽

Literature Search ◽

Primary Tumour ◽

Sun Exposure ◽

Metastatic Basal Cell Carcinoma ◽

Radiation Genetic ◽

The Right

Background: Basal cell carcinomas are malignant slow-growing neoplasms of the epidermal layer of the skin. They are the most common form of skin cancer, accounting for 80% of non-melanoma skin cancers. Metastasis is rare with an incidence rate of 0.0028 to 0.55%. We report a case of an 83 year old male presenting with basal cell carcinoma (BCC) of the right cheek. The tumour was completely excised with close margins. The patient was closely monitored clinically and on follow-up, a mass in the region of the right parotid was identified. Excision of the tail of the right parotid identified a tumour with similar subtype to the primary tumour excised from the cheek confirming diagnosis of metastatic BCC. Methods: A literature search was carried out inclusive of the terms identify existing data and guidelines to determine best evidence based practice. Discussion: Literature search identified aetiology of BCCs and methods of diagnosis and treatment. The search also highlighted an incidence rate of 0.0028 to 0.55% and complications associated with metastasis. The patient underwent a course of radiotherapy as surgery in this case was contraindicated due to history of excision of the parotid tail. Risk factors for developing BCCs include intermittent sun exposure, ionising radiation, genetic predisposition and immunosuppression. Metastases occurs via the lymphatic system or haematogenously. Surgery is the main form of treatment and aims to be curative.

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Trends in basal cell carcinoma incidence rates: a 16-year retrospective study of a population in central Poland

Advances in Dermatology and Allergology ◽

10.5114/ada.2018.73164 ◽

2018 ◽

Vol 35 (1) ◽

pp. 47-52 ◽

Cited By ~ 1

Author(s):

Magdalena Ciążyńska ◽

Joanna Narbutt ◽

Anna Woźniacka ◽

Aleksandra Lesiak

Keyword(s):

Retrospective Study ◽

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Incidence Rates ◽

Central Poland

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Trends in Basal Cell Carcinoma Incidence Rates: A 37-Year Dutch Observational Study

Journal of Investigative Dermatology ◽

10.1038/jid.2012.431 ◽

2013 ◽

Vol 133 (4) ◽

pp. 913-918 ◽

Cited By ~ 75

Author(s):

Sophie C. Flohil ◽

Inge Seubring ◽

Michelle M. van Rossum ◽

Jan-Willem W. Coebergh ◽

Esther de Vries ◽

...

Keyword(s):

Basal Cell Carcinoma ◽

Observational Study ◽

Cell Carcinoma ◽

Basal Cell ◽

Incidence Rates

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Rapid and Continuous Increases in Incidence Rates of Basal Cell Carcinoma in the Southeast Netherlands Since 1973

Journal of Investigative Dermatology ◽

10.1111/j.0022-202x.2004.23306.x ◽

2004 ◽

Vol 123 (4) ◽

pp. 634-638 ◽

Cited By ~ 103

Author(s):

Esther de Vries ◽

Marieke Louwman ◽

Maarten Bastiaens ◽

Frank de Gruijl ◽

Jan Willem Coebergh

Keyword(s):

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Incidence Rates

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Metastatic Basal Cell Carcinoma: A Rare Manifestation of a Common Disease

Case Reports in Medicine ◽

10.1155/2017/8929745 ◽

2017 ◽

Vol 2017 ◽

pp. 1-4 ◽

Cited By ~ 6

Author(s):

Paola Piva de Freitas ◽

César Galusni Senna ◽

Mayara Tabai ◽

Carlos Takahiro Chone ◽

Albina Altemani

Keyword(s):

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Incidence Rates ◽

Common Disease ◽

Submandibular Region ◽

Positron Emission ◽

High Prevalence ◽

Metastatic Basal Cell Carcinoma ◽

Level I

Introduction. Basal cell carcinoma (BCC) is considered the most common malignancy in Caucasians. It constituted about 80% of all nonmelanoma skin tumors and, despite its high prevalence, is an extremely rare occurrence of metastases, with incidence rates varying from 0.0028% to 0.55%.Case Report. A 58-year-old male patient with BCC on the left nasolabial sulcus for 17 years, reporting 3 previous excisions, evolved with local recurrence. A new procedure was performed, and anatomopathological study confirmed sclerosing BCC. Seven months later, he presented with a mass in the left submandibular region. Combined positron-emission tomography and computed tomography (PET-CT) showed cervical hypercaptation in the left cervical level I and vertebral body of L5. Excision of the cervical lesion was performed with diagnosis of sclerosing BCC compromising the submandibular gland. Biopsy of the lumbar lesion was found to be compatible with bone metastasis.Conclusion. BCC represents a very common entity, and the presence of metastasis, although infrequent, must be proposed because of the greater morbidity and mortality of this complication. This case shows the importance of early diagnosis and intervention in BCC as a way to avoid unfavorable outcomes.

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Ultrastructure of Mouse Basal Cell Carcinoma Exhibiting Sebaceous Differentiation

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s1431927600003214 ◽

1980 ◽

Vol 38 ◽

pp. 738-739

Author(s):

Victoria L. Wade ◽

Winslow G. Sheldon ◽

James W. Townsend ◽

William Allaben

Keyword(s):

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Topical Application ◽

Basal Cell ◽

Sebaceous Gland ◽

Rats And Mice ◽

Mixed Tumors

Sebaceous gland tumors and other tumors exhibiting sebaceous differentiation have been described in humans (1,2,3). Tumors of the sebaceous gland can be induced in rats and mice following topical application of carcinogens (4), but spontaneous mixed tumors of basal cell origin rarely occur in mice.

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