High-dose ranitidine for the prevention of recurrent peptic ulcer disease in rheumatoid arthritis patients taking NSAIDs.

1996 ◽  
Vol 10 (3) ◽  
pp. 347-351 ◽  
Author(s):  
S Ten Wolde ◽  
BA Dijkmans ◽  
M Janssen ◽  
J Hermans ◽  
CB Lamers
Keyword(s):  
Rheumatoid Arthritis ◽  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
High Dose ◽  
Ulcer Disease

Peptic ulcer disease

2020 ◽  
pp. 2849-2861
Author(s):  
Joseph Sung
Keyword(s):  
Peptic Ulcer ◽  
Proton Pump Inhibitor ◽  
Peptic Ulcer Disease ◽  
Proton Pump ◽  
Gastric Ulcers ◽  
High Dose ◽  
Recurrent Bleeding ◽  
Ulcer Disease ◽  
H Pylori ◽  
Line Of Therapy

Helicobacter pylori infection, use of nonsteroidal anti-inflammatory drugs (NSAIDs) including aspirin, and smoking are the most important causes of peptic ulcer disease. Peptic ulcer disease is characterized by a history of waxing and waning symptoms of localized, dull, aching pain in the upper abdomen. Bleeding is the most common complication; free perforation of the stomach or duodenum into the peritoneal cavity is uncommon but serious. The diagnosis of peptic ulcer disease is made by endoscopy, which offers an opportunity for biopsy of gastric ulcers (which may be malignant) and reveals important prognostic indicators in patients with bleeding ulcers. A single daily dose of a proton pump inhibitor gives quick relief of symptoms and effective healing of peptic ulcers in 4 to 6 weeks. The management of patients with upper gastrointestinal haemorrhage requires a multidisciplinary medical and surgical approach. Early risk stratification based on clinical and endoscopic criteria allows delivery of appropriate care, with endoscopic intervention now widely accepted as the first line of therapy. This should be followed by administration of a high dose of an intravenous proton pump inhibitor to further reduce recurrent bleeding. Treatment of H. pylori is a cure for peptic ulcer disease in most patients. This usually requires at least two antimicrobial agents, with the most popular triple therapy combining a proton pump inhibitor with any two of amoxicillin, metronidazole, and clarithromycin for 7 to 14 days. Eradication of H. pylori infection, avoidance of high-dose NSAIDs or aspirin, and the maintenance use of proton pump inhibitors in high-risk individuals are the best ways to prevent recurrence of ulcer and ulcer complications.

Chronic Salicylate Administration in Juvenile Rheumatoid Arthritis: Aspirin "Hepatitis" and Its Clinical Significance

PEDIATRICS ◽  
1978 ◽  
Vol 62 (5s) ◽  
pp. 916-925
Author(s):  
Jane G. Schaller
Keyword(s):  
Rheumatoid Arthritis ◽  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Juvenile Rheumatoid Arthritis ◽  
Clinical Significance ◽  
Clinical Signs ◽  
Hypersensitivity Reactions ◽  
Ulcer Disease ◽  
Gastric Irritation

Salicylates provide the backbone of therapy in juvenile rheumatoid arthritis. They are effective in controlling the disease approximately 75% of the time if they are properly used. Salicylate administration is relatively safe if carefully done. Serum salicylate levels should not exceed 30 mg/dl routinely. Patients, physicians, and parents should be alert to early clinical signs of toxicity. Chief hazards of chronic salicylate administration other than salicylism (which should be uniformly preventable) include gastric irritation with questionable relationship to peptic ulcer disease, and rare serious hepatotoxicity, bleeding diatheses, or hypersensitivity reactions.

Role of herpes simplex virus type 1 (HSV-1) in the pathogenesis of peptic ulcer disease

2001 ◽  
Vol 120 (5) ◽  
pp. A136-A137
Author(s):  
K TSAMAKIDES ◽  
E PANOTOPOULOU ◽  
D DIMITROULOPOULOS ◽  
M CHRISTOPOULO ◽  
D XINOPOULOS ◽  
...  
Keyword(s):  
Peptic Ulcer ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Peptic Ulcer Disease ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Ulcer Disease ◽  
Simplex Virus

Poor outcome and quality of life in female patients undergoing secondary surgery for recurrent peptic ulcer disease

2001 ◽  
Vol 120 (5) ◽  
pp. A491-A491
Author(s):  
G GONZALEZSTAWINSKI ◽  
J ROVAK ◽  
H SEIGLER ◽  
J GRANT ◽  
T PAPPAS
Keyword(s):  
Quality Of Life ◽  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Secondary Surgery ◽  
Ulcer Disease ◽  
Female Patients ◽  
Poor Outcome

The Clinical Significance of Penetration and Confined Perforation in Peptic Ulcer Disease

1953 ◽  
Vol 25 (2) ◽  
pp. 173-201 ◽  
Author(s):  
William S. Haubbich ◽  
James L.A. Roth ◽  
H.L. Bockus
Keyword(s):  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Clinical Significance ◽  
Ulcer Disease

Temporal Trends of Peptic Ulcer Disease in Kashmir, India

JMS SKIMS ◽  
2012 ◽  
Vol 15 (2) ◽  
pp. 136-140
Author(s):  
G M Gulzar ◽  
Showkat A Zargar ◽  
Muzaffar Nazir ◽  
Gul Javid ◽  
Bashir A Khan ◽  
...  
Keyword(s):  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Gastric Outlet Obstruction ◽  
Temporal Trends ◽  
Outlet Obstruction ◽  
Life Time ◽  
Point Prevalence ◽  
Asymptomatic Group ◽  
Ulcer Disease ◽  
Ulcer Perforation

BACKGROUND: Since late 1960s, the prevalence of peptic ulcer disease and its complications has been steadily decreasing. OBJECTIVE: To ascertain the changing trends in the prevalence and complications of peptic ulcer in Kashmir. METHODS: A cohort of 10474 people aged 15-60 years in district Baramulla of Kashmir was interviewed about symptoms, complications, and surgery related to peptic ulcer. People were enquired about smoking, use of NSAIDs, H2 Receptor antagonists, proton pump inhibitors and endoscopies. All symptomatic and randomly selected group of asymptomatic people underwent esophago-gastro-cluodenoscopy. RESULTS: In symptomatic group, 286 (41.45%) people hod peptic ulcer and in asymptomatic group 24 (5.35%) had peptic ulcer. There were 71 already diagnosed cases of peptic ulcer; totaling 381. Thirty three people had surgery for peptic ulcer. The point prevalence of peptic ulcer was 3.54% and lifetime prevalence 8.96%. The highest prevalence was in 4th decade. Bleeding was seen in 23.63%, gastric outlet obstruction 4.20%, ulcer perforation 0.52%. 9.39% of peptic ulcer patients had undergone surgery. When compared to previous study in 1985 in Kashmir, there was decrease in point prevalence of 25%, in life-time prevalence of 20.14%, Gastric outlet obstruction by 51.7%, ulcer perforation by 87%, surgery rate by 60% and bleeding by a marginal 2%. CONCLUSION: Prevalence of peptic ulcerand its complications (except bleeding) are showing downward trend in Kashmir over the last 20 years. JMS 2012;15(2):136-40

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