Chapter VI:CONCENTRATION OF POTASSIUM IN GASTRIC JUICE RECOVERED AFTER HISTAMINE STIMULATION FOLLOWED BY INSULIN STIMULATION

2009 ◽  
Vol 130 (S208) ◽  
pp. 78-113
1964 ◽  
Vol 9 (4) ◽  
pp. 246-255 ◽  
Author(s):  
Jack D. Welsh ◽  
Joe T. Hartzog ◽  
June C. May ◽  
Lois Russell

1964 ◽  
Vol 207 (4) ◽  
pp. 868-872 ◽  
Author(s):  
Don W. Powell ◽  
Basil I. Hirschowitz

A study was made of the effects of intravenous infusions of 100-ml hypertonic (ca. 2,400 mosmoles/kg) solutions of NaCl, mannitol, and glucose on blood and gastric juice of five dogs during histamine stimulation. These were compared to control studies in the same dogs in which no infusion was given or in which isotonic NaCl was infused. Hypertonic solutions, regardless of chemical nature, acutely elevated plasma osmolality by 18–24 mosmoles/kg, raised gastric juice [H+] by 7–10 mEq/liter and [Cl–] by 6–9 mEq/liter. The output of volume, H+, Cl–, and pepsin, however, was unaffected. In the light of these findings the osmolality of the gastric mucosa is judged to be isotonic with plasma and extremely sensitive to external osmotic changes.


1983 ◽  
Vol 244 (4) ◽  
pp. G416-G420
Author(s):  
B. I. Hirschowitz ◽  
E. Molina

Intravenous administration of cimetidine (0.25-2.0 mg X kg-1 X h-1) inhibited histamine-stimulated gastric acid secretion in both intact (Ki = 1.0 mg X kg-1 X h-1) and vagotomized (Ki = 1.75 mg X kg-1 X h-1) dogs. During histamine infusion, all doses of cimetidine reduced gastric volume output; high doses increased gastric juice pepsin and [Na+] and reduced [H+] and [Cl-]. Gastric juice [K+] was not affected during cimetidine infusion. The cimetidine-induced changes in electrolyte concentrations were qualitatively comparable with those observed on withdrawal of histamine stimulation. On termination of cimetidine infusion with continued histamine administration, gastric [K+] and volume output increased immediately, followed 30 min later by an increase in [H+] and a reciprocal decrease in [Na+]; [Cl-] did not recover. The changes in gastric juice electrolytes after termination of cimetidine, with the exception of [Cl-], mimicked the changes observed on initiation of histamine stimulation. These data indicate that the effects of cimetidine may be totally explained by its antagonism of histamine binding to the parietal cell H2-receptor, that vagotomy reduces cimetidine binding to the H2-receptor, and that cimetidine antagonism of histamine is rapidly reversed on removal of the antagonist.


1928 ◽  
Vol 5 (4) ◽  
pp. 611-637 ◽  
Author(s):  
W. Scott Polland ◽  
A. M. Roberts ◽  
Arthur L. Bloomfield

2001 ◽  
Vol 120 (5) ◽  
pp. A588-A588
Author(s):  
R ORTIZ ◽  
L ABREU ◽  
S CALLAFATTI ◽  
A CORAZZA ◽  
M DEGUER ◽  
...  

1955 ◽  
Vol 29 (6) ◽  
pp. 1017-1023 ◽  
Author(s):  
Virginia Richmond ◽  
Ranwel Caputto ◽  
Stewart Wolf

1954 ◽  
Vol 27 (1) ◽  
pp. 98-112 ◽  
Author(s):  
E. Heinz ◽  
K.J. Öbrink ◽  
H. Ulffendahl
Keyword(s):  

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