scholarly journals QUANTITATIVE MEASUREMENTS OF PEPSIN IN GASTRIC JUICE BEFORE AND AFTER HISTAMINE STIMULATION

1929 ◽  
Vol 7 (1) ◽  
pp. 57-74 ◽  
Author(s):  
W. Scott Polland ◽  
Arthur L. Bloomfield
1987 ◽  
Vol 26 (05) ◽  
pp. 192-197 ◽  
Author(s):  
T. Kreisig ◽  
P. Schmiedek ◽  
G. Leinsinger ◽  
K. Einhäupl ◽  
E. Moser

Using the 133Xe-DSPECT technique, quantitative measurements of regional cerebral blood flow (rCBF) were performed before and after provocation with acetazolamide (Diamox) i. v. in 32 patients without evidence of brain disease (normals). In 6 cases, additional studies were carried out to establish the time of maximal rCBF increase which was found to be approximately 15 min p. i. 1 g of Diamox increases the rCBF from 58 ±8 at rest to 73±5 ml/100 g/min. A Diamox dose of 2 g (9 cases) causes no further rCBF increase. After plotting the rCBF before provocation (rCBFR) and the Diamox-induced rCBF increase (reserve capacity, Δ rCBF) the regression line was Δ rCBF = −0,6 x rCBFR +50 (correlation coefficient: r = −0,77). In normals with relatively low rCBF values at rest, Diamox increases the reserve capacity much more than in normals with high rCBF values before provocation. It can be expected that this concept of measuring rCBF at rest and the reserve capacity will increase the sensitivity of distinguishing patients with reversible cerebrovascular disease (even bilateral) from normals.


1960 ◽  
Vol XXXIII (III) ◽  
pp. 417-427 ◽  
Author(s):  
John Kristoffersen

ABSTRACT By means of chromatographic and spectrophotometric methods progesterone and a substance closely similar to 20β-hydroxy-pregn-4-ene-3-one has been detected in luteal tissue from non-pregnant and pregnant cows. In 21 animals quantitative measurements based on a method giving an average net recovery of 56 per cent showed that in pregnancy the average progesterone content in the corpus luteum reached a maximum in the third to fifth month, with low values before and after this period. For 6 nonpregnant cows, the average value was 20.2 μg/g tissue, which is considerably higher than previous values reported in the literature. The relation between these findings and the bovine dependence on a functional corpus luteum in pregnancy is discussed, and it is pointed out that more information about the metabolism of progesterone in cattle is highly desirable.


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jeong Woo Kang ◽  
Yeoun Sook Chun ◽  
Nam Ju Moon

Abstract Background To evaluate the change of accommodation and ocular discomfort according to the display size, using quantitative measurements of accommodation and ocular discomfort through subjective and objective metrics. Methods Forty six subjects without any ophthalmic disease history were asked to watch the documentary movie, using two different sizes of smart devices; smartphones and tablets. Before and after using devices, the near point accommodation (NPA) and the near point convergence (NPC) were measured, and objective accommodation was measured using an auto refractometer/keratometer. The subjective ocular discomfort was assessed through a survey. Results Both devices showed a decrease in post-use NPA and NPC, and the change after use of the smartphone was significantly severe, 1.8 and 2.5 folds respectively, compared to tablet (p = 0.044, p = 0.033, respectively). Neither smartphone nor tablet showed significant changes in the accommodative response induced by dynamic accommodative stimulus of auto refractometer/keratometer (p = 0.240 and p = 0.199, respectively). Subjects showed a more severe increase in ocular discomfort after using smartphones (p = 0.035) and reported feeling tired even with shorter use times (p = 0.012). Conclusions Both devices showed significant decreases in NPA and NPC, and the larger changes were seen when using the small display smartphone. Even within 20minutes of using, subjects start to feel ocular discomfort, and it was more severe and faster after smartphones than tablets. Therefore, the smaller the display size, the greater the adverse impact on eyes, and thus, appropriate display size will need to be selected depending on the time and purpose of use.


1964 ◽  
Vol 9 (4) ◽  
pp. 246-255 ◽  
Author(s):  
Jack D. Welsh ◽  
Joe T. Hartzog ◽  
June C. May ◽  
Lois Russell

2018 ◽  
Vol 06 (07) ◽  
pp. E830-E837 ◽  
Author(s):  
Kazumi Togo ◽  
Tetsuya Ueo ◽  
Kenshi Yao ◽  
Kurato Wada ◽  
Hideho Honda ◽  
...  

Abstract Background and study aims The presence of white opaque substance (WOS) is an endoscopic marker of intestinal metaplasia. Considering that the nature of WOS is absorbed lipid droplets, lipase plays an important role in the lipid absorption process and is inactivated at strong acidity. WOS may only be present in a hypochlorhydria state following Helicobacter pylori infection, and, thus, may not be highly sensitive marker, especially in H. pylori-eradicated patients. We investigated the relationship between WOS and gastric acid conditions. Patients and methods A total of 501 patients were retrospectively evaluated for the presence of WOS at 2 regions of interest using magnifying narrow-band imaging. The pH level of collected gastric juice was also measured. Study end points were (1) prevalence of WOS and its relationship with gastric juice pH in 3 groups: H. pylori-uninfected, H. pylori-infected, and H. pylori-eradicated; (2) the relationship between prevalence of WOS and gastric juice pH before and after proton pump inhibitor (PPI) administration in 29 H. pylori-eradicated cases. Results Prevalence of WOS was 0 % (0 /206), 28.4 % (31/109), and 3.2 % (6/186) in the H. pylori-uninfected, H. pylori-infected, and H. pylori-eradicated groups, respectively. Mean gastric juice pH was significantly higher in WOS-positive cases than in WOS-negative cases in the H. pylori-infected and H. pylori-eradicated groups (P < 0.0001). Mean gastric juice pH increased from 1.1 to 6.9 after PPI administration and WOS prevalence increased from 0 % (0/29) to 45 % (13/29) of cases. Conclusion The prevalence of WOS is closely associated with the neutralization of intragastric pH.


2011 ◽  
Vol 393-395 ◽  
pp. 972-975
Author(s):  
Yong Peng ◽  
Jian Li

The effect and mechanism on gastric juice secretion by electroacupuncturing at Zusanli points on rabbits with modern apparatuses were studied. Zusanli points were stimulated with electroacupunctures to observe the flux of gastric juice in the study. Before and after Cimetidine being injected by the pathway of points, Zusanli points were respectively stimulated with electroacupunctures to observe the flux of gastric juice secretion. The results showed that the flux of gastric juice slowered (P0.05) when the stopping acupuncture group for 10 minutes compared with the during acupuncturing group, but after Cimetidine being injected, the flux of gastric juice secretion did not increase obviously (P>0.05) during acupuncturing for 10 minutes compared with the no acupuncturing group, and also did not increase (P>0.05) stopping acupuncture for 10 minutes compared with no acupuncture. So the study showed that the flux of gastric juice secretion could be increased by electroacupuncturing at Zusanli points, and the mechanism may be come true by the gastric H2 receptor pathway.


2021 ◽  
Vol 15 ◽  
Author(s):  
Anubhav Jain ◽  
Kian Abedinpour ◽  
Ozgur Polat ◽  
Mine Melodi Çalışkan ◽  
Afsaneh Asaei ◽  
...  

Humans' voice offers the widest variety of motor phenomena of any human activity. However, its clinical evaluation in people with movement disorders such as Parkinson's disease (PD) lags behind current knowledge on advanced analytical automatic speech processing methodology. Here, we use deep learning-based speech processing to differentially analyze voice recordings in 14 people with PD before and after dopaminergic medication using personalized Convolutional Recurrent Neural Networks (p-CRNN) and Phone Attribute Codebooks (PAC). p-CRNN yields an accuracy of 82.35% in the binary classification of ON and OFF motor states at a sensitivity/specificity of 0.86/0.78. The PAC-based approach's accuracy was slightly lower with 73.08% at a sensitivity/specificity of 0.69/0.77, but this method offers easier interpretation and understanding of the computational biomarkers. Both p-CRNN and PAC provide a differentiated view and novel insights into the distinctive components of the speech of persons with PD. Both methods detect voice qualities that are amenable to dopaminergic treatment, including active phonetic and prosodic features. Our findings may pave the way for quantitative measurements of speech in persons with PD.


1964 ◽  
Vol 207 (4) ◽  
pp. 868-872 ◽  
Author(s):  
Don W. Powell ◽  
Basil I. Hirschowitz

A study was made of the effects of intravenous infusions of 100-ml hypertonic (ca. 2,400 mosmoles/kg) solutions of NaCl, mannitol, and glucose on blood and gastric juice of five dogs during histamine stimulation. These were compared to control studies in the same dogs in which no infusion was given or in which isotonic NaCl was infused. Hypertonic solutions, regardless of chemical nature, acutely elevated plasma osmolality by 18–24 mosmoles/kg, raised gastric juice [H+] by 7–10 mEq/liter and [Cl–] by 6–9 mEq/liter. The output of volume, H+, Cl–, and pepsin, however, was unaffected. In the light of these findings the osmolality of the gastric mucosa is judged to be isotonic with plasma and extremely sensitive to external osmotic changes.


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