scholarly journals Role of Human Telomerase Reverse Transcriptase and Telomeric-repeat Binding Factor Proteins 1 and 2 in Human Hematopoietic Cells

2000 ◽  
Vol 91 (12) ◽  
pp. 1278-1284 ◽  
Author(s):  
Koji Yamada ◽  
Tomomi Yajima ◽  
Atsuhito Yagihashi ◽  
Daisuke Kobayashi ◽  
Yoko Koyanagi ◽  
...  
Keyword(s):  
Reverse Transcriptase ◽  
Hematopoietic Cells ◽  
Telomeric Repeat ◽  
Telomerase Reverse Transcriptase ◽  
Human Telomerase Reverse Transcriptase ◽  
Binding Factor ◽  
Human Telomerase

scholarly journals The Regulation of ROS- and BECN1-Mediated Autophagy by Human Telomerase Reverse Transcriptase in Glioblastoma

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Xuelu Ding ◽  
Ziyang Nie ◽  
Zhaoyuan She ◽  
Xue Bai ◽  
Qiuhui Yang ◽  
...  
Keyword(s):  
Reverse Transcriptase ◽  
Telomere Maintenance ◽  
High Morbidity ◽  
Telomerase Reverse Transcriptase ◽  
Human Telomerase Reverse Transcriptase ◽  
Telomere Shortening ◽  
Targeting Therapy ◽  
Anticancer Treatment ◽  
Human Telomerase

Glioblastoma (GBM) is the most common and aggressive malignant brain tumor with high morbidity and mortality. Human telomerase reverse transcriptase (hTERT), the catalytic subunit of human telomerase, is overexpressed in most cancers including GBM. It is well known that hTERT can compensate telomere shortening to immortalize cells. However, in addition to the canonical function, hTERT has the roles beyond canonical telomere maintenance. To further understand the effects of hTERT on glioblastoma progression, we investigated the role of hTERT in regulating autophagy—a conserved pathway, by which cells deliver cellular organic material and impaired organelles to the lysosomes for degradation and recycle these cargos to produce energy under a stressful condition. Our results showed that downregulation of hTERT impaired autophagy levels by suppressing BECN1/beclin-1 and induced an increase of reactive oxygen species (ROS), which resulted in cell death ultimately. On the contrary, overexpression of BECN1 or treating cells with the antioxidant N-acetylcysteine (NAC) could restore the survival of hTERT knockdown cells. Our study will provide an additional basis of telomerase-targeting therapy for future clinical anticancer treatment.

CHEMOSENSITIZATION OF BLADDER CANCER CELL LINES BY HUMAN TELOMERASE REVERSE TRANSCRIPTASE ANTISENSE TREATMENT

2004 ◽  
Vol 172 (5) ◽  
pp. 2023-2028 ◽  
Author(s):  
KAI KRAEMER ◽  
SUSANNE FUESSEL ◽  
MATTHIAS KOTZSCH ◽  
SHUANGLI NING ◽  
UTA SCHMIDT ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Reverse Transcriptase ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Bladder Cancer Cell ◽  
Telomerase Reverse Transcriptase ◽  
Human Telomerase Reverse Transcriptase ◽  
Human Telomerase

Detection of human telomerase reverse transcriptase mRNA in urine of patients with bladder cancer: evaluation of an emerging tumor marker

Urology ◽  
2003 ◽  
Vol 62 (2) ◽  
pp. 362-367 ◽  
Author(s):  
N Melissourgos ◽  
N.G Kastrinakis ◽  
I Davilas ◽  
P Foukas ◽  
A Farmakis ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Reverse Transcriptase ◽  
Tumor Marker ◽  
Telomerase Reverse Transcriptase ◽  
Human Telomerase Reverse Transcriptase ◽  
Human Telomerase
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