Perinatal risk factors and coeliac disease in children and young adults: a record linkage study

ObjectiveTo describe the age pattern and temporal evolution of symptoms and signs of intracranial tumours in children and young adults before diagnosis.Design and settingA record linkage study using population-based data from the National Cancer Registry, linked to Clinical Practice Research Datalink (CPRD) and Hospital Episode Statistics (HES).Patient cohortPatients aged 0–24 years when diagnosed with a primary intracranial tumour between 1989 and 2006 in England.MethodsLinked records of relevant symptoms and signs in primary care and hospitals were extracted from CPRD (1989–2006, 181 patients) and HES (1997–2006, 3959 patients). Temporal and age-specific changes in presentation rates before diagnosis of an intracranial tumour, for each of eight symptom groups, were estimated in generalised additive models.ResultsAll symptoms presented with increasing frequency until eventual diagnosis. The frequency of presentation of raised intracranial pressure (ICP) to hospitals rose rapidly to 36.4 per 100 person-months (95% CI 34.6 to 38.4) in the final month before diagnosis in the entire cohort. Clinical features in primary care were less specific: the main features were visual disturbance (rate: 0.49 per 100 person-months; 95% CI 0.33 to 0.72) in newborns to 4-year-olds, headache in 5-year-olds to 11-year-olds (0.64; 0.47 to 0.88), 12-year-olds to 18-year-olds (1.59; 1.21 to 2.08) and 19-year-olds to 24-year-olds (2.44; 1.71 to 3.49). The predominant features at hospital admission were those of raised ICP: between 1.17 per 100 person-months (95% CI 1.08 to 1.26) in newborns to 4-year-olds and 0.77 (0.67 to 0.88) in 19-year-olds to 24-year-olds.ConclusionsNon-localising symptoms and signs were more than twice as common as focal neurological signs. An intracranial tumour should be considered in patients with relevant symptoms that do not resolve or that progress rapidly.

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Perinatal risk factors for suicide in young adults in Taiwan

International Journal of Epidemiology ◽

10.1093/ije/dyt129 ◽

2013 ◽

Vol 42 (5) ◽

pp. 1381-1389 ◽

Cited By ~ 9

Author(s):

Y.-Y. Chen ◽

D. Gunnell ◽

C.-L. Lu ◽

S.-S. Chang ◽

T.-H. Lu ◽

...

Keyword(s):

Risk Factors ◽

Young Adults ◽

Perinatal Risk Factors ◽

Perinatal Risk ◽

Risk Factors For Suicide

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Perinatal risk factors increase the risk of being affected by both type 1 diabetes and coeliac disease

Acta Paediatrica ◽

10.1111/apa.12836 ◽

2014 ◽

Vol 104 (2) ◽

pp. 178-184 ◽

Cited By ~ 31

Author(s):

Emma H. Adlercreutz ◽

Carl Johan Wingren ◽

Raquel P. Vincente ◽

Juan Merlo ◽

Daniel Agardh

Keyword(s):

Risk Factors ◽

Type 1 Diabetes ◽

Coeliac Disease ◽

Perinatal Risk Factors ◽

Perinatal Risk

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Preterm Birth and Disruptive Cerebellar Development: Assessment of Perinatal Risk Factors

Zeitschrift für Geburtshilfe und Neonatologie ◽

10.1055/s-2006-943143 ◽

2006 ◽

Vol 210 (S 5) ◽

Author(s):

A Messerschmidt ◽

D Prayer ◽

PC Brugger ◽

G Zoder ◽

W Sterniste ◽

...

Keyword(s):

Risk Factors ◽

Preterm Birth ◽

Cerebellar Development ◽

Perinatal Risk Factors ◽

Perinatal Risk ◽

Development Assessment

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Coeliac disease is associated with depression in children and young adults with type 1 diabetes: results from a multicentre diabetes registry

Acta Diabetologica ◽

10.1007/s00592-020-01649-8 ◽

2021 ◽

Author(s):

Sascha René Tittel ◽

◽

Désirée Dunstheimer ◽

Dörte Hilgard ◽

Burkhild Knauth ◽

...

Keyword(s):

Type 1 Diabetes ◽

Young Adults ◽

Coeliac Disease ◽

Diabetes Patient ◽

Routine Care ◽

Diabetes Registry ◽

Increased Risk ◽

Treatment Data ◽

Children And Young Adults

Abstract Aims To analyse the association between coeliac disease (CD) and depression in children, adolescents, and young adults with type 1 diabetes (T1D). Methods We included 79,067 T1D patients aged 6–20 years, with at least six months of diabetes duration, and treatment data between 1995 and 2019 were documented in the diabetes patient follow-up registry. We categorized patients into four groups: T1D only (n = 73,699), T1 + CD (n = 3379), T1D + depression (n = 1877), or T1D + CD + depression (n = 112). Results CD and depression were significantly associated (adjusted OR: 1.25 [1.03–1.53]). Females were more frequent in both the depression and the CD group compared with the T1D only group. Insulin pumps were used more frequently in T1D + CD and T1D + depression compared with T1D only (both p < .001). HbA1c was higher in T1D + depression (9.0% [8.9–9.0]), T1D + CD + depression (8.9% [8.6–9.2]), both compared with T1D only (8.2% [8.2–8.2], all p < .001). We found comorbid autism, attention deficit hyperactivity disorder, anxiety, schizophrenia, and eating disorders more frequently in the T1D + CD + depression group compared with T1D only (all p < .001). Conclusions CD and depression are associated in young T1D patients. The double load of T1D and CD may lead to an increased risk for depression. Depression was associated with additional psychological and neurological comorbidities. Aside from imperative CD screening after T1D diagnosis and regular intervals, depression screening might be helpful in routine care, especially in patients with diagnosed CD.

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Low Birth Weight Prevalence in Children Diagnosed with Neurodevelopmental Disorders in Dubai

Global Pediatric Health ◽

10.1177/2333794x211031782 ◽

2021 ◽

Vol 8 ◽

pp. 2333794X2110317

Author(s):

Faisal A. Nawaz ◽

Meshal A. Sultan

Keyword(s):

Risk Factors ◽

Birth Weight ◽

Mental Disorders ◽

Low Birth Weight ◽

Neurodevelopmental Disorders ◽

Autism Spectrum ◽

High Birth Weight ◽

Perinatal Risk Factors ◽

Perinatal Risk ◽

The Impact

The aim of this study is to evaluate the prevalence of low birth weight and other perinatal risk factors in children diagnosed with neurodevelopmental disorders. This is one of the first studies in the Arabian Gulf region focused on the contribution of these factors toward the development of various disorders such as attention-deficit/hyperactivity disorder, autism spectrum disorder, and other mental disorders. This descriptive study was based on qualitative data analysis. We reviewed retrospective information from the electronic medical records of 692 patients in Dubai, United Arab Emirates. The prevalence of low birth weight in children with mental disorders was significantly higher as compared to the general population (16% vs 6% respectively). Furthermore, other risk factors, including high birth weight and preterm birth were noted to have a significant association with neurodevelopmental disorders. Future research on the impact of perinatal risk factors will contribute to advancement of early intervention guidelines.

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