Deregulation of the tumour suppressor genes p14ARF, p15INK4b, p16INK4aand p53 in basal cell carcinoma

2009 ◽  
Vol 160 (6) ◽  
pp. 1215-1221 ◽  
Author(s):  
P. Kanellou ◽  
A. Zaravinos ◽  
M. Zioga ◽  
D.A. Spandidos
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Tumour Suppressor ◽  
Tumour Suppressor Genes ◽  
Suppressor Genes

scholarly journals The gene for the naevoid basal cell carcinoma syndrome acts as a tumour-suppressor gene in medulloblastoma

1997 ◽  
Vol 76 (2) ◽  
pp. 141-145 ◽  
Author(s):  
R Cowan ◽  
P Hoban ◽  
A Kelsey ◽  
JM Birch ◽  
R Gattamaneni ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor

scholarly journals Identification of candidate tumour suppressor genes frequently methylated in renal cell carcinoma

Oncogene ◽  
2010 ◽  
Vol 29 (14) ◽  
pp. 2104-2117 ◽  
Author(s):  
M R Morris ◽  
C Ricketts ◽  
D Gentle ◽  
M Abdulrahman ◽  
N Clarke ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Tumour Suppressor ◽  
Tumour Suppressor Genes ◽  
Suppressor Genes ◽  
Candidate Tumour Suppressor

971: Tumour Suppressor Genes in Transitional Cell Carcinoma of Bladder: The Expression of Maspin and P53

2004 ◽  
Vol 171 (4S) ◽  
pp. 257-257
Author(s):  
Shalom J. Srirangam ◽  
Sue Curtis ◽  
Daniel Burke ◽  
Richard J. Hale ◽  
C.R. Hunt ◽  
...  
Keyword(s):  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Transitional Cell ◽  
Tumour Suppressor ◽  
Tumour Suppressor Genes ◽  
Suppressor Genes

scholarly journals Novel SUFU Frameshift Variant Leading to Meningioma in Three Generations in a Family with Gorlin Syndrome

2019 ◽  
Vol 2019 ◽  
pp. 1-5
Author(s):  
Gustav Askaner ◽  
Ulrikke Lei ◽  
Birgitte Bertelsen ◽  
Alessandro Venzo ◽  
Karin Wadt
Keyword(s):  
Basal Cell ◽  
Regulatory Genes ◽  
Tumour Suppressor ◽  
Hedgehog Pathway ◽  
Tumour Suppressor Genes ◽  
Gorlin Syndrome ◽  
Suppressor Genes ◽  
Pathogenic Variants ◽  
Basal Cell Carcinomas ◽  
Multiple Basal Cell Carcinomas

Gorlin syndrome is mainly caused by pathogenic germline variants in the tumour suppressor genes PTCH1 and SUFU, both regulatory genes in the hedgehog pathway. However, the phenotypes of patients with PTCH1 and SUFU pathogenic variants seem to differ. We present a family with a frameshift variant in the SUFU gene c.954del, p.Asn319Thrfs∗42 leading to meningiomas and multiple basal cell-carcinomas.

Sign in / Sign up

Export Citation Format

Share Document