Investigation of the male pattern baldness major genetic susceptibility loci AR/EDA2R and 20p11 in female pattern hair loss

2012 ◽  
Vol 166 (6) ◽  
pp. 1314-1318 ◽  
Author(s):  
S. Redler ◽  
F.F. Brockschmidt ◽  
R. Tazi-Ahnini ◽  
D. Drichel ◽  
M.P. Birch ◽  
...  
Keyword(s):  
Genetic Susceptibility ◽  
Hair Loss ◽  
Susceptibility Loci ◽  
Male Pattern Baldness ◽  
Female Pattern Hair Loss ◽  
Male Pattern

Hair loss: a clinical update

2019 ◽  
Vol 8 (9) ◽  
pp. 422-429
Author(s):  
Lucy Millar-Hume ◽  
Farah Ali
Keyword(s):  
Hair Loss ◽  
Androgenic Alopecia ◽  
Levels Of Evidence ◽  
Female Pattern Hair Loss ◽  
Male Pattern

Hair loss is classified into non-scarring and scarring alopecias, the latter being further subdivided into primary and secondary forms. These classifications are also referred to as non-cicatricial and cicatricial hair loss. This article focuses on androgenic alopecia (AGA) and will, at times, be referred to as male pattern hair loss (MPHL) or female pattern hair loss (FPHL). Essentially, AGA is a non-scarring, benign form of alopecia, generally related to ageing and where, on the whole, a proportion of hair can grow back. Aestheticians should be prepared to answer a patient's questions and concerns and be familiar with the current levels of evidence surrounding the myriad of treatments available.

Investigation of six novel susceptibility loci for male androgenetic alopecia in women with female pattern hair loss

2013 ◽  
Vol 72 (2) ◽  
pp. 186-188 ◽  
Author(s):  
Silke Redler ◽  
Kathy Dobson ◽  
Dmitriy Drichel ◽  
Stefanie Heilmann ◽  
Sabrina Wolf ◽  
...  
Keyword(s):  
Hair Loss ◽  
Androgenetic Alopecia ◽  
Susceptibility Loci ◽  
Female Pattern Hair Loss

scholarly journals Genetic Prediction of Male Pattern Baldness

2016 ◽  
Author(s):  
Saskia P Hagenaars ◽  
W David Hill ◽  
Sarah E Harris ◽  
Stuart J Ritchie ◽  
Gail Davies ◽  
...  
Keyword(s):  
Hair Loss ◽  
Genetic Architecture ◽  
Prediction Algorithm ◽  
Uk Biobank ◽  
Psychosocial Effects ◽  
Male Pattern Baldness ◽  
Adverse Health Outcomes ◽  
Common Genetic Variants ◽  
Using Data ◽  
Male Pattern

AbstractMale pattern baldness can have substantial psychosocial effects, and it has been phenotypically linked to adverse health outcomes such as prostate cancer and cardiovascular disease. We explored the genetic architecture of the trait using data from over 52,000 male participants of UK Biobank, aged 40-69 years. We identified over 250 independent novel genetic loci associated with severe hair loss. By developing a prediction algorithm based entirely on common genetic variants, and applying it to an independent sample, we could discriminate accurately (AUC = 0.82) between those with no hair loss from those with severe hair loss. The results of this study might help identify those at the greatest risk of hair loss and also potential genetic targets for intervention.

scholarly journals Author Correction: GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Nicola Pirastu ◽  
Peter K. Joshi ◽  
Paul S. de Vries ◽  
Marilyn C. Cornelis ◽  
Paul M. McKeigue ◽  
...  
Keyword(s):  
Susceptibility Loci ◽  
Male Pattern Baldness ◽  
Male Pattern

scholarly journals Epidemiological profile of patients presenting to dermatology department of a tertiary care hospital during nationwide lockdown due to COVID-19: a retrospective study from north India

2021 ◽  
Vol 9 (2) ◽  
pp. 443
Author(s):  
Faizan Younus Shah ◽  
Irfan Tasaduq ◽  
Yaqzata Bashir ◽  
Ifrah Shafat Kitab ◽  
Aaqib Aslam Shah ◽  
...  
Keyword(s):  
Herpes Zoster ◽  
Hair Loss ◽  
Seborrheic Dermatitis ◽  
Tertiary Care ◽  
P Value ◽  
Care Hospital ◽  
Dermatology Department ◽  
Female Pattern Hair Loss ◽  
Number Of Patients ◽  
Male Pattern

Background: The COVID-19 pandemic has seen an unprecedented lockdown with restrictions on human movement and interaction, imposed throughout the world to contain the spread of the disease. This gave us the unique opportunity to study the pattern of patients presenting to the dermatology out-patient department during this period.Methods: The study was a retrospective observational study involving the assessment of patient records from 25th March 2020 to 7th June 2020. This period corresponds to the duration of strictly imposed nationwide lockdown which was relaxed with phased resumption from 8th June 2020, termed as unlock 1.Results: A decrease in the absolute as well as proportional number of patients was seen in majority of the cases with a statistically significant proportional decline being seen in cases of allergic contact dermatitis (p-value =0.007), acne (p value <0.001), male pattern hair loss (p value <0.001) and female pattern hair loss (p value <0.001), verrucae (p value=0.01), seborrheic dermatitis (p value <0.001), ephelids (p value <0.001), melasma (p value<0.001), post-inflammatory hyperpigmentation (p value=0.006). However, there were certain disorders whose proportionate representation increased significantly during the lockdown period contrary to prevalent belief. These disorders included urticaria (p value <0.001), herpes zoster (p value <0.001), scabies (p value =0.01), generalized pruritus (p value <0.001) and prurigo (p value <0.001).Conclusions: Disorders like acne, male pattern hair loss, female pattern hair loss, verrucae, seborrheic dermatitis, ephelids, melasma and post-inflammatory hyperpigmentation which do not cause significant morbidity showed a significant decrease in proportional representation. The proportionate representation of disorders like urticaria, herpes zoster, scabies, generalized pruritus and prurigo increased significantly during the lockdown period.

Proscar and Propecia: the Gary and Jerry show

2020 ◽  
pp. 7-24
Author(s):  
Eugene H. Cordes
Keyword(s):  
Hair Loss ◽  
Genetic Disease ◽  
Single Gene ◽  
Prostate Gland ◽  
Genetic Defect ◽  
Male Pattern Baldness ◽  
Functional Equivalent ◽  
Male Sex ◽  
Metabolic Basis ◽  
Male Pattern

Tracking down the metabolic basis of a remarkable human single-gene genetic disease provided the insight required to discover drugs to prevent prostate gland growth in aging men (benign prostatic hyperplasia, BPH) and prevent hair loss in men (male pattern baldness). Victims of this genetic disease are born with the appearance of females and are recognized as such. However, at puberty, they undergo a transformation and develop the characteristics of males. The underlying genetic defect is a mutation in the gene that codes for the enzyme 5-alpha reductase (5AR), which promotes conversion of testosterone (T) into the more potent male sex hormone dihydrotestosterone (DHT). Lack of sufficient DHT in utero prevents the full expression of male anatomy at birth, an issue that is corrected at the time of puberty when a surge of male sex hormones occurs. These men have a very small prostate gland that never grows, do not lose their hair, and do not get acne. This strongly suggests that DHT is the causative agent of BPH, male pattern baldness, and acne. An inhibitor of 5AR would create the functional equivalent of the genetic defect and would be expected to be effective in shrinking an enlarged prostate gland and slowing or preventing hair loss and acne in men. Finasteride is such an inhibitor and has met expectations. It is marketed as Proscar for BPH and Propecia for male pattern baldness. Finasteride is a teratogen (can cause birth defects) and has not been developed for acne for that reason.

Endoscopic Forehead and Brow-Lift Surgery for Male Patients

1996 ◽  
Vol 13 (4) ◽  
pp. 315-319
Author(s):  
Anthony J. Geroulis ◽  
Bryan J. Kemker
Keyword(s):  
Wound Healing ◽  
Hair Loss ◽  
Endoscopic Technique ◽  
Nerve Injuries ◽  
Male Pattern Baldness ◽  
Brow Lift ◽  
Chief Complaints ◽  
Male Patients ◽  
Orbital Rim ◽  
Male Pattern

We describe endoscopic forehead and brow-lift surgery for male patients. The endoscopic approach to the male forehead and brow-lift differs distinctly from the female lift. One difference is the consideration for placement of the incisions with respect to male pattern baldness. Another is the elevation of the brow on the orbital rim. Men often possess deeper forehead rhytids which are resistant to flattening out. The approach described allows for an easy solution by scoring of the tissue parallel to the rhytid in the subgaleal plane endoscopically. Our endoscopic technique uses both subgaleal and subperiosteal planes in a composite dissection. With this approach, the surgeon has the ability to regulate the elevation of the brow and deal with rhytids. Our experience with this method involves five male patients aged 44–56 years. Their chief complaints were excessive wrinkles of the forehead and a scowl appearance. To date, there have been no complications including infections, hair loss, or nerve injuries. All of the scars are well camouflaged within the hairline, with good wound healing. All patients have been pleased with the results of their surgery.

scholarly journals GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Nicola Pirastu ◽  
Peter K. Joshi ◽  
Paul S. de Vries ◽  
Marilyn C. Cornelis ◽  
Paul M. McKeigue ◽  
...  
Keyword(s):  
Susceptibility Loci ◽  
Male Pattern Baldness ◽  
Male Pattern

scholarly journals Is Every Patient of Hair Loss a Candidate for Hair Transplant?—Deciding Surgical Candidacy in Pattern Hair Loss

2021 ◽  
Author(s):  
Robert H. True
Keyword(s):  
Hair Loss ◽  
Body Dysmorphic Disorder ◽  
Young Patients ◽  
Androgenic Alopecia ◽  
Hair Transplantation ◽  
Detailed History ◽  
Hair Transplant ◽  
Female Pattern Hair Loss ◽  
Unrealistic Expectations ◽  
Male Pattern

AbstractPatterned hair loss which includes both male pattern hair loss (MPHL) or androgenic alopecia (AGA) and female pattern hair loss (FPHL) is the most common indication for hair transplant surgery. However, not all such patients are candidates for hair transplants. There are eight conditions that cause patients to not be appropriate candidates. These are: diffuse unpatterned alopecia (DUPA), cicatricial alopecia (CA), patients with unstable hair loss, patients with insufficient hair loss, very young patients, patients with unrealistic expectations, patients with psychologic disorders such as body dysmorphic disorder (BDD) and trichotillomania, and patients who are medically unfit. In addition, there are patients who are poor candidates and who should undergo hair transplantation only if they understand and accept limited results. The key to identifying these patients involves performing careful and detailed history and examination at the time of consultation.

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