Hair loss: a clinical update

Hair loss is classified into non-scarring and scarring alopecias, the latter being further subdivided into primary and secondary forms. These classifications are also referred to as non-cicatricial and cicatricial hair loss. This article focuses on androgenic alopecia (AGA) and will, at times, be referred to as male pattern hair loss (MPHL) or female pattern hair loss (FPHL). Essentially, AGA is a non-scarring, benign form of alopecia, generally related to ageing and where, on the whole, a proportion of hair can grow back. Aestheticians should be prepared to answer a patient's questions and concerns and be familiar with the current levels of evidence surrounding the myriad of treatments available.

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Is Every Patient of Hair Loss a Candidate for Hair Transplant?—Deciding Surgical Candidacy in Pattern Hair Loss

Indian Journal of Plastic Surgery ◽

10.1055/s-0041-1739247 ◽

2021 ◽

Author(s):

Robert H. True

Keyword(s):

Hair Loss ◽

Body Dysmorphic Disorder ◽

Young Patients ◽

Androgenic Alopecia ◽

Hair Transplantation ◽

Detailed History ◽

Hair Transplant ◽

Female Pattern Hair Loss ◽

Unrealistic Expectations ◽

Male Pattern

AbstractPatterned hair loss which includes both male pattern hair loss (MPHL) or androgenic alopecia (AGA) and female pattern hair loss (FPHL) is the most common indication for hair transplant surgery. However, not all such patients are candidates for hair transplants. There are eight conditions that cause patients to not be appropriate candidates. These are: diffuse unpatterned alopecia (DUPA), cicatricial alopecia (CA), patients with unstable hair loss, patients with insufficient hair loss, very young patients, patients with unrealistic expectations, patients with psychologic disorders such as body dysmorphic disorder (BDD) and trichotillomania, and patients who are medically unfit. In addition, there are patients who are poor candidates and who should undergo hair transplantation only if they understand and accept limited results. The key to identifying these patients involves performing careful and detailed history and examination at the time of consultation.

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DEVELOPMENT OF THE EMULGE LFOR THE ANDROGENIC ALOPECIA TREATMENT

EUREKA Health Sciences ◽

10.21303/2504-5679.2020.001427 ◽

2020 ◽

Vol 5 ◽

pp. 82-91

Author(s):

Inna Yarema ◽

Marianа Fedorovska ◽

Natalia Polovko

Keyword(s):

Hair Loss ◽

Mechanical Stability ◽

Later Life ◽

Acid Value ◽

Potassium Sorbate ◽

Androgenic Alopecia ◽

Sophora Japonica ◽

Female Pattern Hair Loss ◽

Semi Solid ◽

Biopharmaceutical Properties

Androgenic alopecia (AGA) is the most common alopecia that is heritable, androgen-dependent and occurs in both sexes with defined patterns such as Male pattern hair loss in men and Female pattern hair loss in women. AGA affects at least 50 % of men by the age of 50 years, and up to 70 % of all males in later life. The aim.The research was aimed to substantiate the optimal concentration of excipients and active pharmaceutical ingredients (APIs) of the emulgel intended for the topical treatment of androgenic alopecia. Materials and methods. In this study the samples of the emulgel bases containing different carbomer Ultrez10 concentrationsin the range of 0.3–0.6 % and its neutralizers (0.1 % of potassium sorbate and 0 % or 0.2 % of triethanolamine) were used. Colloidal and thermal stability, pH, rheological properties (structural viscosity, mechanical stability, degree of thixotropy) of these samples were determined. The emulgel samples with different percentages of the Serenoa repens dry extract and the Sophora japonica tincture were used in the biopharmaceutical studies. The samples of the emulgel with the antioxidant butylhydroxytoluene different concentrations (0 %, 0.01 %, 0.02 %, 0.03 %) were used to determine acid value during 1 year of the emulgel storage. Results and discussion. It was experimentally substantiated the optimal ratio of the emulgel ingredients that provide good APIs release and necessary consumer properties of the semi-solid remedy like application compliance, safety and storage stability. Conclusions. Physicochemical, rheological and biopharmaceutical properties of emulgel bases have been studied. It was found that the base №2 (in which the concentrations of Carbomer Ultraz 10, potassium sorbate and triethanolamine are 0.3 %, 0.1 %, 0.2 % respectively) possessed the optimal properties. Considering the results of the complete range of experimental research it was developed the final formulation of the emulgel intended for AGA treatment which included the concentration of the APIs, neutralizers, preservatives, antioxidant and fragrance.

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Investigation of the male pattern baldness major genetic susceptibility loci AR/EDA2R and 20p11 in female pattern hair loss

British Journal of Dermatology ◽

10.1111/j.1365-2133.2012.10877.x ◽

2012 ◽

Vol 166 (6) ◽

pp. 1314-1318 ◽

Cited By ~ 26

Author(s):

S. Redler ◽

F.F. Brockschmidt ◽

R. Tazi-Ahnini ◽

D. Drichel ◽

M.P. Birch ◽

...

Keyword(s):

Genetic Susceptibility ◽

Hair Loss ◽

Susceptibility Loci ◽

Male Pattern Baldness ◽

Female Pattern Hair Loss ◽

Male Pattern

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Epidemiological profile of patients presenting to dermatology department of a tertiary care hospital during nationwide lockdown due to COVID-19: a retrospective study from north India

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20210421 ◽

2021 ◽

Vol 9 (2) ◽

pp. 443

Author(s):

Faizan Younus Shah ◽

Irfan Tasaduq ◽

Yaqzata Bashir ◽

Ifrah Shafat Kitab ◽

Aaqib Aslam Shah ◽

...

Keyword(s):

Herpes Zoster ◽

Hair Loss ◽

Seborrheic Dermatitis ◽

Tertiary Care ◽

P Value ◽

Care Hospital ◽

Dermatology Department ◽

Female Pattern Hair Loss ◽

Number Of Patients ◽

Male Pattern

Background: The COVID-19 pandemic has seen an unprecedented lockdown with restrictions on human movement and interaction, imposed throughout the world to contain the spread of the disease. This gave us the unique opportunity to study the pattern of patients presenting to the dermatology out-patient department during this period.Methods: The study was a retrospective observational study involving the assessment of patient records from 25th March 2020 to 7th June 2020. This period corresponds to the duration of strictly imposed nationwide lockdown which was relaxed with phased resumption from 8th June 2020, termed as unlock 1.Results: A decrease in the absolute as well as proportional number of patients was seen in majority of the cases with a statistically significant proportional decline being seen in cases of allergic contact dermatitis (p-value =0.007), acne (p value <0.001), male pattern hair loss (p value <0.001) and female pattern hair loss (p value <0.001), verrucae (p value=0.01), seborrheic dermatitis (p value <0.001), ephelids (p value <0.001), melasma (p value<0.001), post-inflammatory hyperpigmentation (p value=0.006). However, there were certain disorders whose proportionate representation increased significantly during the lockdown period contrary to prevalent belief. These disorders included urticaria (p value <0.001), herpes zoster (p value <0.001), scabies (p value =0.01), generalized pruritus (p value <0.001) and prurigo (p value <0.001).Conclusions: Disorders like acne, male pattern hair loss, female pattern hair loss, verrucae, seborrheic dermatitis, ephelids, melasma and post-inflammatory hyperpigmentation which do not cause significant morbidity showed a significant decrease in proportional representation. The proportionate representation of disorders like urticaria, herpes zoster, scabies, generalized pruritus and prurigo increased significantly during the lockdown period.

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Frequency of Different Pattern of Hair Loss in Pakistani Men Using BASP Classification

10.53350/pjmhs211551187 ◽

2021 ◽

Vol 15 (5) ◽

pp. 1187-1189

Author(s):

S. Nasreen ◽

T. Malik ◽

H. S. Memon ◽

M. Izhar ◽

S. M. S. Shah ◽

...

Keyword(s):

Hair Loss ◽

Cross Sectional Study ◽

Androgenic Alopecia ◽

Cross Sectional ◽

Treatment Plans ◽

Suitable Treatment ◽

Surgical Treatments ◽

Study Setting ◽

Written Informed Consent ◽

Male Pattern

Objective: To determine the frequency of different hair loss using BASP classification in Pakistani men. Study Design: Cross-Sectional Study. Setting: Study was conducted at Department of Dermatology, Abbasi Shaheed Hospital, Karachi. Duration: Six months starting 6th August 2019 till 5th January 2020 Material and Methods: Total 157 diagnosed patients with hair loss who met the diagnostic criteria were included. Brief history was taken and demographic information was recorded after taking written informed consent. Male pattern of hair loss (MPHL) was checked and categorized using BASP classification. Data was analyzed by SPSS 24.0. Results: In this study out of 157 patients, mean and standard deviation of age and duration of hair loss were 33.14±12.49 years and 1.89± 0.44 years, respectively. The Pattern of hair loss distribution showed that 34 (21.7%) were L type, 66 (42%) were M type, 35 (22.3%) were C type, and 22 (14%) were U type patterned hair loss. Conclusion: Assessment of male pattern hair loss using BASP classification found that M type hair loss was more prevalent. Currently, there are effective medical and surgical treatments available for men. However, the knowledge of pattern of hair loss in our population would help in choosing suitable treatment plans. Keywords: Male Pattern hair loss, Androgenic alopecia and BASP classification

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Changes in the sebaceous gland in patients with male pattern hair loss (androgenic alopecia)

Journal of Cosmetic Dermatology ◽

10.1111/jocd.12153 ◽

2015 ◽

Vol 14 (3) ◽

pp. 178-184 ◽

Cited By ~ 10

Author(s):

Katsuhiro Kure ◽

Tsukasa Isago ◽

Takeshi Hirayama

Keyword(s):

Hair Loss ◽

Sebaceous Gland ◽

Androgenic Alopecia ◽

Male Pattern

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The potential of androgenic alopecia management from plant derivatives

Food Research ◽

10.26656/fr.2017.4(s2).s09 ◽

2020 ◽

Vol 4 (S2) ◽

pp. 1-13

Author(s):

N.M. Noor ◽

N.Z. Nazri ◽

N.A. Mohamad-Salam ◽

Z.I. Abdul-Rasid ◽

R. Hasham ◽

...

Keyword(s):

Hair Loss ◽

Hair Growth ◽

Self Esteem ◽

Androgenetic Alopecia ◽

Depression And Anxiety ◽

Androgenic Alopecia ◽

Growth Cycles ◽

Male Pattern Baldness ◽

Male Pattern

Hair loss or alopecia is a common dermatological issue that can affect millions of human population of all ages and both gender, male and female. Frequently, alopecia has been found to be associated with significant adverse effects or reduction of psychological and self-esteem. Consequently, this may lead to psychological problems such as depression and anxiety, thus it may negatively impact the quality of life as well. There are several types of hair loss including androgenetic alopecia (AGA), alopecia areata (AA), alopecia totalis (AT), Alopecia Universalis (AU), cicatricial alopecia (CA), senescent alopecia (SA), traction alopecia (TA) and telogen effluvium. However, this review will focus on the androgenic alopecia only. Androgenic alopecia (AGA) also known as male pattern baldness is referred to as hair loss that often occurs in men after puberty caused by the androgen. In addition, this review will discuss on the hair growth cycles and their mechanism on the androgenic alopecia and lastly the management of androgenic alopecia using plant derivatives and methods used in order to prolong the efficacy of androgenetic alopecia treatment.

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Comparative study between the efficacy of topical sildenafil and topical minoxidil in the treatment of male androgenic alopecia

QJM ◽

10.1093/qjmed/hcab093.007 ◽

2021 ◽

Vol 114 (Supplement_1) ◽

Author(s):

Ali Abdulkareem Al-Shabkhon ◽

Adel Ahmed Halim Emam ◽

Ahmed Abd Elfattah Afify

Keyword(s):

Hair Loss ◽

Treated Group ◽

Treatment Modalities ◽

Androgenic Alopecia ◽

Men And Women ◽

Female Pattern Hair Loss ◽

Topical Minoxidil ◽

Temporal Side ◽

Male Patients ◽

Incidence Increase

Abstract Background Androgenic alopecia is the most common form of alopecia in men and women. Its incidence increase with age, many treatment modalities are available but results are variable. Androgenetic alopecia is a hereditary thinning of the hair induced by androgens in genetically susceptible men and women. Also known as male-pattern hair loss or common baldness in men and female-pattern hair loss in women. Thinning of hair usually begins between 12 and 40 years old in males and females. Inheritance is polygenic. Aim of the study To evaluate and compare the efficacy, safety and side effects of topical sildenafil and topical minoxidil in the treatment of androgenic alopecia Patients and methods This exploratory pilot study included 30 male patients suffering from androgenic alopecia. Included patients were divided into 2 equal groups based on treatment received; one group received 1% topical sildenafil and the other group received 55 topical minoxidil. Assessment of treatment response was done using trichoscopy. Results Sildenafil treated group showed statistically significant increase in VH and TH count at 18 cm point, 24 cm point after treatment compared to before treatment. While, temporal side showed statistically significant increase in VH only. minoxidil treated group showed statistically significant increase in TH count, T/V hair ratio and hair thickness at 18 cm point and temporal side after treatment compared to before treatment. VH count was significantly decreased after treatment compared to before treatment at 18 cm point. At 24 cm point, only TH was significantly increased after treatment compared to before treatment.

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