Insulin-like growth factor-l blood levels in severely burned patients: effects of time post injury, age of patient and severity of burn

Despite extensive research it has proved difficult to establish the role of diet in the aetiology of common types of cancer. Obesity and alcohol definitely increase the risk for several types of cancer, but the importance of particular foods and nutrients is not clear. Part of the difficulty is our poor understanding of the physiological changes that might mediate the effect of diet on cancer risk. Recent research in prospective studies with biobanks of stored blood samples has shown that the serum concentration of insulin-like growth factor-1 (IGF-1) is positively associated with the risk for both breast cancer in women and prostate cancer in men. It is also known that circulating IGF-1 concentrations can change in response to nutritional changes including energy and protein restriction, and some studies suggest that, even within well-nourished western populations, men and women with relatively high intakes of protein from dairy products have higher blood levels of IGF-1. These observations have led to the hypothesis that high intakes of protein from dairy products might increase the risk for some cancers by increasing the endogenous production of IGF-1. Further evaluation of this hypothesis requires clinical nutritional studies of the effects of diet on IGF-1 metabolism, and large epidemiological studies of cancer risk incorporating reliable measures of diet and serum IGF-1 concentrations.

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About evaluation of nutritive state in premature infants

CHILDREN INFECTIONS ◽

10.22627/2072-8107-2021-20-1-23-27 ◽

2021 ◽

Vol 20 (1) ◽

pp. 23-27

Author(s):

K. V. Dashichev ◽

N. V. Olendar ◽

T. G. Pukhova ◽

E. P. Sitnikova

Keyword(s):

Growth Factor ◽

High Risk ◽

Premature Infants ◽

Neonatal Period ◽

Blood Levels ◽

Insulin Like Growth Factor ◽

Fetal Hypoxia ◽

Premature Newborns ◽

Neonatal Adaptation ◽

Fetal Stage

Insulin-like growth factor 1 (IGF-1) plays an important role in the energy balance of the newborn baby's body, is associated with protein stores, which allows us to consider its level as an indicator of nutritional status.Objective: to study the value of insulin-like growth factor 1 and basic nutrients in the blood in premature infants in the process of neonatal adaptation.Materials and methods. Dynamics blood levels of insulin-like growth factor 1 in premature newborns included two trends: decrease (1 group) and increase (2 group). During a pregnancy most mothers of newborns from 1 group had been nonspecific respiratory and urinary-sexual organs’sinfectious diseases, in mothers of newborns from 2 group prevailed disorders which carried high risk of fetal hypoxia. During a neonatal period blood levels of albumen of newborns from 1 group decreased and blood levels of glucose increased; blood levels of nutrients in newborns from 2 group did not change.Conclusions. Dynamics blood levels of insulin-like growth factor 1 in premature newborns are markers of metabolism’s processes which were originated in fetal stage and continue in the neonatal period.

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Maternal and cord blood levels of Insulin-like Growth Factors-I and -II and Insulin-Like Growth Factor Binding Protein-1: correlation with birth weight and maternal anthropometric indices

Ceylon Medical Journal ◽

10.4038/cmj.v52i2.1019 ◽

2009 ◽

Vol 52 (2) ◽

pp. 48 ◽

Cited By ~ 10

Author(s):

AN Pathmaperuma ◽

KH Tennekoon ◽

L Senanayake ◽

EH Karunanayake

Keyword(s):

Growth Factors ◽

Birth Weight ◽

Growth Factor ◽

Cord Blood ◽

Binding Protein ◽

Blood Levels ◽

Insulin Like Growth Factor ◽

Anthropometric Indices ◽

Factor Binding ◽

Insulin Like Growth Factors

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GLYCOSYLATED FIBRONECTIN AND INHIBIN ARE LOWER AND ANTI-MÜLLERIAN HORMONE IS HIGHER IN UMBILICAL CORD BLOOD WHEN MOTHERS HAVE PREECLAMPSIA

Endocrine Practice ◽

10.4158/ep-2019-0448 ◽

2020 ◽

Vol 26 (3) ◽

pp. 318-327

Author(s):

Bridget DiPrisco ◽

Ajay Kumar ◽

Bhanu Kalra ◽

Gopal V. Savjani ◽

Zoe Michael ◽

...

Keyword(s):

Growth Factor ◽

Cord Blood ◽

Umbilical Cord ◽

Immunosorbent Assay ◽

Plasma Protein ◽

Umbilical Cord Blood ◽

Enzyme Linked Immunosorbent Assay ◽

Blood Levels ◽

Insulin Like Growth Factor ◽

Tertiary Teaching

Objective: Preeclampsia is a common disorder of pregnancy, causing significant morbidity and mortality for mothers and infants. Several molecules, including glycosylated fibronectin (GlyFn), the inhibin-related proteins, anti-müllerian hormone (AMH), and the insulin-like growth factor axis, are altered in maternal plasma in the setting of preeclampsia; however, these molecules have not been previously measured in cord blood of infants born to mothers with preeclampsia, which may represent changes in fetal physiology. We evaluated potential biomarkers of preeclampsia in umbilical cord blood to fill the gap in knowledge. Methods: This is a case-control study of 196 neonates born at a tertiary teaching hospital in Boston from 2010–2017. Forty-nine neonates born to mothers with preeclampsia were matched 1:3 by gestational age, sex, and birth weight z-score with 147 controls. Eleven analytes were measured in cord blood by enzyme-linked immunosorbent assay. Binary logistic regression analyses were performed to evaluate associations between preeclampsia and analytes. Results: Mean cord blood levels of GlyFn and total inhibin were significantly lower in neonates born to mothers with preeclampsia compared to controls, and AMH levels were significantly higher in males born to mothers with preeclampsia than male controls. Associations remained significant after controlling for maternal and neonatal characteristics. Conclusion: Cord blood levels of GlyFn and inhibin are decreased and AMH (male) levels are increased in infants of preeclamptic mothers, which is opposite the pattern these biomarkers show in serum of mothers with preeclampsia. These molecules may be important in the pathophysiology and long-term effects of preeclampsia on the developing fetus. Abbreviations: AMH = anti-müllerian hormone; ELISA = enzyme-linked immunosorbent assay; GlyFn = glycosylated fibronectin; IGF = insulin-like growth factor; IGFBP5 = insulin-like growth factor binding protein 5; LOD = limit of detection; PAPP-A = pregnancy-associated plasma protein A; PAPP-A2 = pregnancy-associated plasma protein A2

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