Leptin levels in infertile male patients are correlated with inhibin B, testosterone and SHBG but not with sperm characteristics

2007 ◽  
Vol 30 (5) ◽  
pp. 439-444 ◽  
Author(s):  
Branko Zorn ◽  
Joško Osredkar ◽  
Helena Meden-Vrtovec ◽  
Gregor Majdic
2014 ◽  
Vol 55 (2) ◽  
pp. 134 ◽  
Author(s):  
Dae Sung Hwang ◽  
Tae Gyeong Jeon ◽  
Hyun Jun Park ◽  
Nam Cheol Park

2021 ◽  
Vol 0 (0) ◽  
pp. 0
Author(s):  
Hong Huang ◽  
Xue-Jun Shang ◽  
Zhi-Gang Wu ◽  
Wei-Kang Chen ◽  
Qian-Jin Fei ◽  
...  

2015 ◽  
Vol 156 (3) ◽  
pp. 105-112
Author(s):  
Márta Erdei ◽  
Réka Eszter Cserepes ◽  
Antal Bugán

Introduction: The effectiveness of fertility treatments is influenced by the health care professionals’ knowledge regarding infertility as well as their empathy. Aim: The aim of the study was to examine infertility-related knowledge and perceptions of emotional and mind/body consequences of infertility among medical students. Methods: A questionnaire design was used. Data were obtained from 112 medical university students (76 women, 36 men) who participated involuntary and compensation-free. Results: Medical students’ knowledge concerning infertility proved to be incomplete and ambiguous. Subjects underestimated the presence of mind/body and emotional symptoms caused by infertility in men particularly, and overestimated some emotional concerns in women, e.g. sadness. Conclusions: Medical students have gaps in their subject-specific knowledge, so that they need more (even practical) information regarding infertility during their studies. Students’ conceptions about emotional and physical consequences of infertility are distorted by stereotypes. The risk of these biases is that it could make it difficult to perceive patients in a non-distorted way, especially infertile male patients. Orv. Hetil., 2015, 156(3), 105–112.


Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. 4105-4105
Author(s):  
Khalil Al Farsi ◽  
Murtadha K. Al-Khabori ◽  
Fehmida Zia ◽  
Moez Abdul-Rahim ◽  
Yusra Al-Habsi ◽  
...  

Abstract Abstract 4105 Introduction: Conditioning chemotherapy prior to allogeneic bone marrow transplantation (BMT) can induce impairment in gonadal function. Patients with beta-thalassemia major generally undergo BMT at a young age and long-term data on its effects on gonadal function in this patient population are limited. Aims and objectives: To address the effect of BMT on gonadal function in long term survivors with beta-thalassemia major following successful BMT. Materials and methods: The hormonal profiles of gonadotrophins (LH and FSH), sex hormones (total and free testosterone in males, and 17 beta-estradiol in females) and inhibin B were assayed yearly after BMT. We analyzed data on patients who underwent BMT between January 1996 and June 2009 in whom the pubertal process should have started. Results: A total of 84 patients received BMT for thalassemia major; 51 (20 females and 31 males) have reached the age of puberty at the time of this analysis. Median age at transplant was 10 years (range: 3 – 17). With a median follow-up of 8 years (range: 2–15), the median age at last follow-up was 18 years (range: 13 – 26). All transplants were from matched sibling donors. Conditioning was myeloablative and consisted of: Busulfan, total dose of 600mg/m2 and Cyclophosphamide, total dose 200mg/kg (BuCy) before January 2005 and Busulfan, total dose 520mg/m2, Fludarabine, total dose 180mg/m2 and ATG, total dose 40mg/kg (BuFluATG) from January 2005 onwards. The impact of BMT appears to be different in the two sexes. 18 of 20 (80%) female patients had evidence of primary ovarian failure. Leydig cell failure was seen in only two male patients. However, injury to the germinal epithelium (as shown by low inhibin B levels which is predictive of oligo- or azoospermia) was seen in 22 of 31 (70%) male patients. A correlation was not found between the low inhibin B levels and age at BMT or type of conditioning regimen. Conclusion: Our data confirm that gonads in male and female thalassemic patients are affected by the cytotoxic effects of the preparative regimens of BMT, albeit at different levels. These findings emphasize the need for vigilant long term follow up of thalassemic patients post-BMT so that those requiring hormone replacement therapy can be identified and treated early. These findings are also important for pre- and post-BMT counseling. Disclosures: No relevant conflicts of interest to declare.


2013 ◽  
Vol 5 (2) ◽  
pp. 76-79
Author(s):  
KP Biswas ◽  
Jayesh Amin ◽  
Asit Kumar Dutta ◽  
Kumud Kunwar ◽  
Veena G Shinde ◽  
...  

ABSTRACT Rising number of infertile males in India provokes the need of evidence-based comprehensive formula addressing unattended causes of male infertility. There is an innovative product*, a combikit available in Indian market, containing 30 tablets of antioxidant, multivitamin, amino acid and mineral tablets, with documented evidence on ingredients in treatment of male infertility, and 25 tablets of clomiphene citrate which is a timetested drug in treatment of male infertility (in particular oligospermia and/or asthenospermia). In order to assess efficacy of the product in Indian infertile male patients, we undertook phase IV multicentric clinical study, at 18 centers across India in 100 patients. Very high couple pregnancy rate of 53% was reported. As first line treatment of male infertility (in particular oligospermia and/or asthenospermia), the use of this innovative product therefore holds a strong promise. How to cite this article Amin J, Mishra SK, Dutta AK, Kunwar K, Shinde VG, Chauhan A, Sud S, Maurya R, Nepal N, Sarode P, Biswas KP, Mazumder GP, Chitrabanshi M, Shibe S, Shukla R, Trivedi N, Dayal M, Sortey D, Shukla S, Gawade B. Indian Clinical Experience on Innovative Product in Treatment of Male Infertility. J South Asian Feder Obst Gynae 2013;5(2):76-79.


2022 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Mariela Holzer ◽  
Estefanía Massa ◽  
Sergio Ghersevich

2020 ◽  
Author(s):  
Angelika Szatmári

Célok A tanulmány célja a Magyarországon eddig alig, vagy nem használt betegvezetési technikák alkalmazása meddőségi zavarokkal küzdő férfi betegek körében. A kezelés időszakában ¬az információk nyújtása mellett – az egyéni támogatás keretében hozzájárulni a keletkező hatások, tapasztalatok, ismeretek feldolgozásához, továbbá a stresszel való adaptív megküzdési stratégiák kialakításához, valamint a reproduktivitást befolyásoló egészségmagatartás változók közvetlen vagy közvetett módosításához. Közvetett célként tekintjük a kezelések, valamint a biztonságos betegellátás hatékonyságának támogatását az ellátottak ismereteinek bővítésével, továbbá a betegelégedettségi mutatók kedvező irányú változásának elősegítését. A rendelkezésre álló pszichológiai vizsgálóeszközök segítségével felmérni az általunk kidolgozott betegvezetési program hatékonyságát. Módszerek A vizsgálatot kizárólag férfi faktoros meddőséggel küzdők körében, kísérleti (N=57) és kontrollcsoport (N=51) keretében végeztük. A betegek részletes kivizsgálását, valamint a veszteségre adott válaszreakcióinak és a betegségükkel kapcsolatos tájékozottság felmérését követően a kísérleti csoport tagjai 5 alkalommal betegvezetésben részesültek. A kontrollcsoportnál a pszichológiai önjellemző diagnosztikai kérdőívek felvételére a kutatás elején és végén, a célcsoportoknál a foglalkozásokat megelőzően, majd azt követően került sor. Eredmények Az intervenciós csoport nagyfokú tudatossággal rendelkezett a diagnózisokról, valamint a javasolt kezelések természetéről és céljairól. Az intervenciós csoport szignifikánsan célirányos probléma fókuszú megküzdési stratégát alkalmazott a meddőségi kezelés során. A betegek a beavatkozással szembeni elégedettségről számoltak be, ami a kísérleti csoport BDI és STAI pontszámainak csökkenésében is tükröződik. Következtetés: A fertilitásproblémákkal küzdők számára paramedikális tanácsadással kedvezőbb pszichés jóllét biztosítható a professzionális segítők aktív közreműködésével. A páciensek hatékony, célzott és problémaspecifikus segítségnyújtásban részesülhetnek. A férfi-meddőség ellátásában kiemelt szerepet kell biztosítani az egészségügyi ellátók; az ápolók, a reproduktív orvoslás, a mentálhigiénés szakember által nyújtott paramedikális tanácsadásnak.


2018 ◽  
Vol 16 (7) ◽  
pp. 469-474 ◽  
Author(s):  
Aylin Esmailkhani ◽  
Mohammad Taghi Akhi ◽  
Javid Sadeghi ◽  
Behrooz Niknafs ◽  
Abed Zahedi Bialvaei ◽  
...  

Author(s):  
Priyanka Roy ◽  
Pranay Kumar Phukan ◽  
Debojit Changmai ◽  
Surajeet Boruah

Background: Pesticides, insecticides can damage the male reproductive system in a number of ways. They may cause reproductive toxicity with direct damage to the structure of the cells or as a result of biotransformation into metabolites. They can alter DNA structure. They may also act like hormones in the endocrine system and disrupt the function of the natural endogenous hormones, when doing so they are often called endocrine disrupting chemicals. The objective of the study was to evaluate the association of infertility with pesticide and insecticide exposure among the infertile male patients attending Out Patient Department of Assam Medical College and Hospital.Methods: The pesticides and insecticides used by the population were cypermethrin, thiaclopride, acetamiprid, emmacetin benzoate A total of 55 oligospermic infertile male patients were taken for the study. Twenty-seven among them were exposed to pesticides and rest twenty-eight unexposed cases were taken as control group. Semen analysis was done along with serum FSH, LH and Testosterone. Scrotal ultrasonography of the subjects was also done. One way ANOVA test and t-test assuming two unequal variances were applied to find out the statistical significance of the association of pesticides with their infertility. p<0.05 was taken to be significant.Results: A significant decrease in sperm concentration was found in the exposed group. Also, a significant increase in serum LH was found in the exposed group. A significant decrease in sperm concentration and serum testosterone along with a significant increase in serum FSH and LH was found with increase in duration of exposure to pesticides and insecticides.Conclusions: The gonadotoxic effect of pesticides and insecticides was reflected from the study and it was concluded that pesticide and insecticide exposure has got a definite relation with the infertility of the subjects evaluated in the study.


2005 ◽  
Vol 7 (2) ◽  
pp. 121-126 ◽  
Author(s):  
Tamer M. Said ◽  
Nabil Aziz ◽  
Rakesh K. Sharma ◽  
Iwan Lewis-Jones ◽  
Anthony J. Thomas ◽  
...  

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