scholarly journals Pesticides, insecticides and male infertility

2017 ◽  
Vol 6 (8) ◽  
pp. 3387 ◽  
Author(s):  
Priyanka Roy ◽  
Pranay Kumar Phukan ◽  
Debojit Changmai ◽  
Surajeet Boruah
Keyword(s):  
Semen Analysis ◽  
Statistical Significance ◽  
Endocrine Disrupting Chemicals ◽  
Sperm Concentration ◽  
Serum Testosterone ◽  
Exposed Group ◽  
Control Group ◽  
Infertile Male ◽  
Insecticide Exposure ◽  
Male Patients

Background: Pesticides, insecticides can damage the male reproductive system in a number of ways. They may cause reproductive toxicity with direct damage to the structure of the cells or as a result of biotransformation into metabolites. They can alter DNA structure. They may also act like hormones in the endocrine system and disrupt the function of the natural endogenous hormones, when doing so they are often called endocrine disrupting chemicals. The objective of the study was to evaluate the association of infertility with pesticide and insecticide exposure among the infertile male patients attending Out Patient Department of Assam Medical College and Hospital.Methods: The pesticides and insecticides used by the population were cypermethrin, thiaclopride, acetamiprid, emmacetin benzoate A total of 55 oligospermic infertile male patients were taken for the study. Twenty-seven among them were exposed to pesticides and rest twenty-eight unexposed cases were taken as control group. Semen analysis was done along with serum FSH, LH and Testosterone. Scrotal ultrasonography of the subjects was also done. One way ANOVA test and t-test assuming two unequal variances were applied to find out the statistical significance of the association of pesticides with their infertility. p<0.05 was taken to be significant.Results: A significant decrease in sperm concentration was found in the exposed group. Also, a significant increase in serum LH was found in the exposed group. A significant decrease in sperm concentration and serum testosterone along with a significant increase in serum FSH and LH was found with increase in duration of exposure to pesticides and insecticides.Conclusions: The gonadotoxic effect of pesticides and insecticides was reflected from the study and it was concluded that pesticide and insecticide exposure has got a definite relation with the infertility of the subjects evaluated in the study.

scholarly journals Effect of aqueous extract of Date Palm Pollen (DPP) on the sperm characteristic and Serum Testosterone, FSH and LH Values in albino male rats treated with sodium floride

2014 ◽  
Vol 38 (2) ◽  
pp. 41-47
Author(s):  
Salah M. M. AL-Chalabi
Keyword(s):  
Aqueous Extract ◽  
Date Palm ◽  
Sperm Concentration ◽  
Serum Testosterone ◽  
Male Rats ◽  
Maximum Effect ◽  
Control Group ◽  
Abnormal Sperm ◽  
Group 2 ◽  
Date Palm Pollen

     The present study was undertaken to evaluate the effect of aqueous extract of Date Palm Pollen DPP on the testicular function and serum testosterone, FSH and LH hormones value. Thirty five male rats were divided randomly into five equal groups. Group 1: received 0.5 ml of distilled water (control group), group 2: was treated orally 0.250 p.p.m of sodium florid (NaF) (with volume of 0.5 ml / rat), Group 3: was treated with 0.250 p.p.m of NaF and 50 mg/kg. B.W. of DPP extract (0.5ml D.W \rat), Group 4: was treated with 0.250 p.p.m of NaF and 100 mg/kg. B.W. of DPP extract and Group 5: was treated with 0.250 p.p.m of NaF and 150 mg/kg. B.W. of DPP extract. The results showed  significant (P< 0.05) decrease in sperm concentration, motility and significant (P< 0.05) increases in dead and abnormal sperm in the group 2 in comparison to control, while all groups of  DPP extract showed significant (P< 0.05) increase in  sperm concentration, motility and decrease in dead and abnormal sperm. Maximum effect was observed in animals treated with a dose of 150 mg/kg of DPP extract, also the results revealed significant (P< 0.05) increase in testosterone, FSH and LH hormones in groups treated with DDP in comparison to G1andG2. Male rats received DPP for 50 days showed significant (P< 0.05) increases in body and testes weight as compared to G1andG2. In conclusion the results revealed that the aqueous extract of DPP pollen can be used as a sex enhancer and seems to cure male infertility.

scholarly journals Anthropometric Assessment after Slow Breathing Exercise in Type 2 Diabetic Male Patients

2020 ◽  
Vol 5 (2) ◽  
Keyword(s):  
Statistical Significance ◽  
Control Group ◽  
Study Group ◽  
Physical And Mental Health ◽  
Anthropometric Parameters ◽  
Breathing Exercise ◽  
Male Patients ◽  
Slow Breathing ◽  
The Impact

Background: Yoga based slow breathing exercise (SBE) has several beneficial effects on physical and mental health. Objectives: To observe the impact of slow breathing exercise on anthropometric parameters in male patients with type 2 diabetes mellitus (T2DM). Methods: This prospective interventional study was conducted on sixty (60) male diagnosed T2DM patients aged 45-55 years with duration of disease 5-10 years enrolled from Out Patients Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University, and Dhaka. By simple random technique the subjects were divided into control group (n=30) and study group (n=30). Yoga based slow breathing exercise was practiced by the study group for 30 minutes twice daily for 3 months. Height, weight, body mass index (BMI), waist circumference, hip circumference and waist/hip ratio were assessed at the start of the study and after 3 months. Independent sample and paired t-test were used for statistical analysis and p<0.05was considered as statistical significance. Results: In this study the value of mean BMI was significantly (p=<0.05) reduced after 3 months of SBE. Again, all the anthropometric parameters were significantly (p=>0.05) increased after 3 months in the group who did not undergo SBE. Conclusion: Anthropometric parameters were improved after slow breathing exercise for 3 months.

The Effects of Combined Oral Antioxidants on Male Infertility

2018 ◽  
Vol 9 (SPL1) ◽  
Author(s):  
Ali Hadi Sabhan
Keyword(s):  
Male Infertility ◽  
Semen Analysis ◽  
Single Agent ◽  
Sperm Concentration ◽  
Membrane Integrity ◽  
Semen Parameters ◽  
Duration Of Treatment ◽  
Male Patients ◽  
Initiation Of Therapy

High reactive oxygen species (ROS) levels was considered as an important factor of male infertility that can result in DNA damage, decrease motility and damage membrane integrity. The role of antioxidants is to maintain the balance between ROS production and their clearance which improve sperm parameters and enhance male fertility. Sixty six male patients with median age of 29 years with a mean period of infertility of 1.5 year that attend the infertility clinic in Al-Diwaniya Maternity and Pediatric Hospital were selected randomly in this study which extend from January 2013 to October 2014 (22 months).The patients were selected to have idiopathic oligo-astheno-teratozoospermia,they underwent a detailed history,general and genital physical examination,Two semen analyses,baseline hormone profile and scrotal Doppler ultrasound examination. All patients were given a combination of oral antioxidants including vitamin E (400 IU. once daily),coenzyme Q10 (75 mg. tablet twice a day),zinc sulphate (15 mg. tablet three time a day) and L-carnitine (1000 mg. twice a day) for three months duration of treatment. Semen analysis was repeated after three months from initiation of therapy and was evaluated for changes in volume,concentration,motility and morphology in comparison with baseline semen analyses and any pregnancy was also documented. Thirteen patients (19%) get pregnancy after a period of 2 to 3 months,other patients show variable changes in their seminal analysis after 3 months. Thirty patients (45%) show increasing in seminal volume of 0.5 to 2 ml., while the sperm concentration was increased in 28 patients (42%). Twenty two patients (33%) show increasing in motility, morphology was increased in 34 patients (51%).From all 66 patients; 6 patients (9 %) get improvement in all four parameters,while 9 patients (14 %) get improvement in only 3 parameters,20 patients (30 %) get improvement in only 2 parameters,23 patients (35 %) get improvement in only one parameter and 8 patients (12 %) had no improvement in any parameter. This study demonstrates a possible role of combined oral antioxidants in the improvement of semen parameters and pregnancy rate for selected infertile men with superiority for the use of combination of antioxidants rather than single agent treatment.

Seminal fluid analysis changes after testicular varicocelectomy in a sample of Iraqi patients

2021 ◽  
Vol 3 (1) ◽  
pp. 13-25
Author(s):  
Anwar Majed ◽  
Manal Rasheed ◽  
Mohammed Jasim
Keyword(s):  
Seminal Fluid ◽  
Sperm Count ◽  
Semen Analysis ◽  
Statistical Significance ◽  
Sperm Concentration ◽  
P Value ◽  
Factors Affecting ◽  
Fluid Analysis ◽  
Medical City ◽  
Fluid Parameters

Background: Semen analysis measures ejaculate volume, pH, sperm count, motility, forward progression, and morphology. Although semen analysis is not a test for infertility, it is considered the most important laboratory test in the evaluation of male fertility. There are many factors affecting the seminal fluid parameters and testicular varicocele is one of them. Varicoceles are the most commonly seen and correctable male infertility factor. Varicocelectomy is a common operation performed for infertile males with clinical varicocele. The aim of study to evaluate the seminal fluid parameters changes after testicular varicocelectomy. Patients and Method: A prospective cohort study was done at the Al Sader Medical City in Najaf during the period from (March-October 2019). The study include 30 males with age between 18 and 32 years old who had a clinical varicocele. Seminal fluid analysis was done one before surgery and another one three months after surgery and compare between the two tests to evaluate the changes in the parameters was done, which include seminal fluid liquefaction, volume, color, PH, sperm concentration, motility and morphology. Results: There were 30 patients enrolled in this study with a mean age of 23.8 ± 3.36. Seminal fluid concentration was 19.1 ± 7.2 million/ml and it was significantly increased postoperatively by almost 84% than preoperative concentration to reach 35.1 ± 11.3 (P ≤ 0.001). The changes in progressive motile sperms’ percent improved after varicocelectomy but not reach the statistical significance (P≥0.935). The mean ± SD percent of normal morphology sperms percent preoperatively was 46.9 ± 22.9 %, and after operation, it elevated to 50.9 ± 18.6 (p value≥ 0.336 ).The patients is divided in to two subgroups (normospermic and oligospermic subgroup). Conclusion: There is a significant improvement in sperm concentration. While there is significant improvement in sperm concentration in oligospermic subgroup, so the infertile patient who has oligospermia with varicocele will get better outcome after varicocelectomy. Keywords: Seminal fluid, analysis changes, testicular varicocelectomy.

scholarly journals Ligation of the left renal vein in epm1-wistar rats: functional and morphologic alterations in the kidneys, testes and suprarenal glands

1997 ◽  
Vol 115 (4) ◽  
pp. 1475-1484 ◽  
Author(s):  
José Carlos Costa Baptista-Silva ◽  
Miriam Sterman Dolnikoff ◽  
Luiz Antonio Ribeiro Moura ◽  
José Osmar Medina Pestana ◽  
Jose Gilberto Henriques Vieira ◽  
...  
Keyword(s):  
Renal Vein ◽  
Wistar Rats ◽  
Normal Values ◽  
Statistical Significance ◽  
Left Renal Vein ◽  
Serum Testosterone ◽  
Control Group ◽  
Male Adult ◽  
Initial Surgery ◽  
Suprarenal Glands

OBJECTIVE: The ligation of the left renal vein (LLVR) in man is a contraversial procedure in view of the risks of lesion to the renal parenchyma. With the objective of studying the morphologic and functional alterations caused by these lesions, we conducted experimental research with rats. MATERIAL AND METHODS: 64 male adult EPM1-WISTAR rats were used, divided into 8 groups - 4 for LLRV and four for control. Each LLRV group and corresponding control group were sacrificed progressively on the 7th, 15th, 30th and 60th day after the initial surgery. RESULTS: We found morphofunctional alterations only in animals that underwent LLRV in the four periods of sacrifice.The proteinuria creatinine in serum, testosterone in serum and serum corticosterone in serum showed practically no alteration in relation to the normal values for rats. Statistically significant severe histological lesions were found in the kidneys and testes of the LLRV groups. Lesions in the suprarenal glands were also present in these groups, but no sufficient to demonstrate statistical significance CONCLUSION: Based on these results we can conclude that the ligation of the left renal vein is a procedure of high risk in these animals.

scholarly journals NEGATIVE EFFECTS OF SMOKING ON SEMEN PARAMETERS AFTER VARICOCELECTOMY

2021 ◽  
Author(s):  
Muhammet Buğday ◽  
ersoy öksüz ◽  
murat dursun ◽  
serhan çimen ◽  
Muhammet sulukaya ◽  
...  
Keyword(s):  
Semen Analysis ◽  
Healing Process ◽  
Sperm Concentration ◽  
Recovery Process ◽  
World Health ◽  
Semen Parameters ◽  
Negative Effects ◽  
Quitting Smoking ◽  
Negative Role ◽  
Male Patients

Background: The negative effects of varicocele and smoking on infertility are known. In our study, we aimed to evaluate the effect of smoking on the healing process after varicocelectomy. Methods and Materials: 378 male patients who have undergone varicocelectomy operation were included in the study. Patients were divided into three groups as non-smokers, patients who smoke less than 10 cigarettes per day and patients who smoke 10 or more cigarettes per day. Semen analysis of the patients before varicocelectomy operation and three months after varicocelectomy operation were evaluated and semen volume, sperm concentration and sperm motility were evaluated according to WHO (World Health Organizations) guidelines. NCSS (Number Cruncher Statistical System) 2007 (Kaysville, Utah, USA) program was used for statistical analysis. Results: Patient age changed between 16 and 52 and the mean age is 27,20±6,74. When cigarette usage was evaluated, it was determined that 52,82% of patients (n=220) were non-smokers, 13,8% of patients (n=52) smoke less than 10 cigarettes per day and 28,0% of patients (n=106) smoke 10 or more cigarettes per day Improvement in sperm concentration and motility rates after varicocelectomy was determined to be lower in 10 or more cigarette smoking group compared to other groups. Conclusions: It is shown that cigarettes play a negative role in recovery process after varicocelectomy operation. Knowing that smoking negatively affects the success of the operation may contribute to patients’ quitting smoking.

scholarly journals Evaluation of the Spermatogenic Activity of Polyherbal Formulation in Oligospermic Males

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Syed Ammar Hussain ◽  
Ahsan Hameed ◽  
Furqan Nasir ◽  
Yang Wu ◽  
Hafiz Ansar Rasul Suleria ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Semen Analysis ◽  
Sperm Concentration ◽  
Pharmacological Properties ◽  
Polyherbal Formulation ◽  
Fertility Status ◽  
Semen Volume ◽  
Serum Hormone ◽  
Male Patients

The therapeutic use of natural herbs is an ancient human civilization act and the numbers of people have reliance on their pharmacological properties and preferred to use the natural herbs. People also use to consume these herbs as supplements to energize, bolster, and eventually enhance sexual ability. Polyherbal formulation (PHF) is one of these herbal amalgams that can be used to treat sexual dysfunction including erectile dysfunction, impotence, ejaculation dysfunction, and hypogonadism. The pilot study was aimed at evaluating the capacity of PHF in enhancing the spermatogenic potential of oligospermic patients. Thirty-six male patients with oligospermia were enrolled and randomized either to treatment (n = 23) with PHF (750 mg/d in three doses for 90 days) or to placebo (n = 13) in the same protocol. The preintervention semen analysis was compared with posttreatment semen analysis. Based on the postintervention semen analysis, patients were advised to undergo eitherin vitrofertilization (IVF) or intracytoplasmic sperm injection (ICSI) to assess their fertility status. After polyherbal treatment, there was a 256% increase in sperm concentration (9.59±4.37×106/mL to25.61±8.6×106/mL; P ≤0.001), 154% increase in semen volume (1.7±0.14 mL to4.32±0.38 mL; P ≤0.001), and 215% increase in sperm motility (15.43±2.40% to48.65±5.10%; P ≤ 0.001) on day 90 from baseline. Furthermore, a significant improvement and regulation were also observed in serum hormone levels with PHF treatment as compared to the placebo group. The present study demonstrated the evidence on synergistic spermatogenic effect of PHF as attributed in ayurveda for the treatment of oligospermia leading to infertility.

scholarly journals Use of Biosimilar Follicle-Stimulating Hormone in Asthenozoospermic Infertile Patients: A Multicentric Study

2020 ◽  
Vol 9 (5) ◽  
pp. 1478
Author(s):  
Maurizio De Rocco Ponce ◽  
Carlo Foresta ◽  
Rocco Rago ◽  
Alessandro Dal Lago ◽  
Giancarlo Balercia ◽  
...  
Keyword(s):  
Dna Fragmentation ◽  
Sperm Count ◽  
Semen Analysis ◽  
Follicle Stimulating Hormone ◽  
Sperm Concentration ◽  
Comparable Efficacy ◽  
Control Group ◽  
Multicentric Study ◽  
Progressive Motility ◽  
Stimulating Hormone

There is increasing data in favour of follicle-stimulating hormone (FSH) therapy in patients with oligo-asthenozoospermia and normal-range gonadotropins in order to increase sperm count and above all sperm motility. Some studies showed an improvement in DNA fragmentation and spontaneous pregnancy. Recently, biosimilar FSH has been marketed with the same indications. We performed a retrospective multicentric case-control study involving 147 asthenozoospermic patients between 18 and 45 years of age. A total of 97 patients were treated with biosimilar FSH 150 UI three times a week for 3 months, while 50 control subjects received no treatment. Patients were evaluated at baseline and after 3 months with semen analysis including DNA fragmentation, testicular colour Doppler ultrasound, and blood tests. Spontaneous pregnancies were recorded during a further follow-up period of 6 months. Treated patients showed after treatment a statistically significant increase in sperm concentration, total sperm count, and total motile sperm, as well as improved progressive motility and non-progressive motility. DNA fragmentation showed a significant reduction. Conversely, in the control group, no significant change was found. Pregnancy rate was significantly higher in treated patients. These data suggest comparable efficacy of biosimilar FSH in the treatment of male infertility; however, larger studies are needed to confirm our results.

scholarly journals Association of erectile dysfunction and urolithiasis

2014 ◽  
Vol 86 (3) ◽  
pp. 215 ◽  
Author(s):  
Alper Otunctemur ◽  
Emin Ozbek ◽  
Suleyman Sami Cakir ◽  
Murat Dursun ◽  
Emre Can Polat ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Metabolic Disorders ◽  
Serum Testosterone ◽  
Urinary Stone ◽  
Stone Disease ◽  
Control Group ◽  
Urinary Stone Disease ◽  
Urinary Tract Calculi ◽  
Male Patients ◽  
The Relationship

Objectives: In recent years, it has been shown that there is association between metabolic syndrome and urinary stone disease. Stone disease and erectile dysfunction (ED) are considered as systemic diseases which are associated with hormonal and metabolic disorders. Therefore we investigated the relationship between ED and urinary tract calculi. Material and methods: 98 male patients with urolithiasis and 59 randomly selected male patients without stone disease were included in the study. Serum testosterone (T) levels were measured and International Index of Erectile Function (IIEF)-15 questionnaire forms were used to assess ED. Results: The prevalence of ED was found 29% (29 patients) in the urolithiasis group. Sixty-nine patients (71%) had no ED; 16 (16.3%) had mild, 5 (5.1%) had moderate and 8 (8.2%) had severe ED. None of the patients in the control group had severe or modarete ED, six patients (10.2%) had mild ED. Serum T levels were detected at the level of biochemical hypogonadism on 13 patients with stones (13.3%) and T levels were detected at the lower limit in 18 (18.3%) patients. Conclusion: In our study we have shown that ED and low T levels are significantly associated with urolithiasis. We propose that the patients with urolitiasis should be evaluated for ED and hypogonadism.

scholarly journals A Comparative Analysis of the Altered Levels of Human Seminal Plasma Constituents as Contributing Factors in Different Types of Male Infertility

2021 ◽  
Vol 43 (3) ◽  
pp. 1307-1324
Author(s):  
Ashutosh Vashisht ◽  
Pankaj Kumar Ahluwalia ◽  
Gagandeep Kaur Gahlay
Keyword(s):  
Male Infertility ◽  
Seminal Plasma ◽  
Clinical Stage ◽  
Control Group ◽  
Obstructive Azoospermia ◽  
Infertile Male ◽  
Contributing Factors ◽  
Immunological Markers ◽  
Different Types ◽  
Male Patients

(1) Background: The relationships between the biochemical and immunological components in seminal plasma and their physiological effects on male reproductive system have been underreported. In this study, we evaluated the potential of several seminal plasma biochemical and immunological markers in the pathophysiological developments of the infertile male patients. The study was designed to identify and assess different markers that may be associated with semen functions in different types of male infertility. (2) Methods: A total of 50 infertile male patients who underwent checkup for fertility assessment and 50 fertile controls were included in this study. The complete medical history of each recruited participant was reviewed. The infertile sub-groups (non-obstructive azoospermia (NOA), asthenozoospermia (AS), normozoospermic infertile (NI), and oligozoospermia (OZ)) were characterized based on sperm motility and concentration, while NI patients were included after a thorough check up of their female partners as well. We investigated each sample for 21 different analytes, enzymes, trace elements, and immunological markers to find crucial markers posing as contributing factors to a specific type of male infertility. (3) Results: The levels of 15 out of 21 markers, assayed from the seminal plasma of infertile males, were significantly altered in comparison to fertile controls (p < 0.05). For the first time, microprotein levels were also analyzed. The presence of monocytes, lymphocytes, and granulocytes was limited to semen from NOA patients, while a significant increase in the level of platelets was observed in AS. Hierarchical clustering and ROC-AUC analysis identified the three most significant markers (zinc, LDH, and TG) for the healthy control group and asthenozoospermic group (AUC, of 0.92 and 0.81, respectively). (4) Conclusions: The altered levels of biochemical and immunological markers in seminal plasma might be associated with the different male infertility profiles and could be required for the sperm metabolism and maintenance. However, a larger sample size and follow up analysis is required for establishing the hypothesized panel of markers as biomarkers at clinical stage.

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