Factors associated with the successful or unsuccessful withdrawal of antipsychotic drug therapy prescribed for people with learning disabilities

1996 ◽  
Vol 40 (4) ◽  
pp. 322-329 ◽  
Author(s):  
D. Branford
Keyword(s):  
Learning Disabilities ◽  
Drug Therapy ◽  
Antipsychotic Drug ◽  
Factors Associated

Review of Clinical Handbook of Antipsychotic Drug Therapy.

1981 ◽  
Vol 26 (3) ◽  
pp. 225-225
Author(s):  
Oakley S. Ray
Keyword(s):  
Drug Therapy ◽  
Antipsychotic Drug

scholarly journals Knowledge about hypertension and factors associated with the non-adherence to drug therapy

2014 ◽  
Vol 22 (3) ◽  
pp. 491-498 ◽  
Author(s):  
Mayckel da Silva Barreto ◽  
Annelita Almeida Oliveira Reiners ◽  
Sonia Silva Marcon
Keyword(s):  
Drug Therapy ◽  
Healthcare Service ◽  
Cross Sectional Study ◽  
Medication Regimen ◽  
Cross Sectional ◽  
Poor Knowledge ◽  
Factors Associated ◽  
Medication Regimen Complexity ◽  
Hypertensive Drug ◽  
Complex Drug

OBJECTIVES: to identify the degree of knowledge of people with hypertension concerning the disease and to verify the factors associated with the non-adherence to anti-hypertensive drug therapy.METHOD: Cross sectional study, involving 422 people. Data collection took place at their homes, between December 2011 and March 2012, through interviews using the following instruments: Medication Adherence Questionnaire (MAQ-Q), Medication Regimen Complexity Index (MRCI) and a guide with questions related to sociodemographic profile, satisfaction with healthcare service and knowledge about the disease.RESULTS: 42.6% did not adhere to the drug therapy and 17.7% had poor knowledge about the disease. Factors associated with the non-adherence were: complex drug therapy, poor knowledge about the disease and dissatisfaction with the healthcare service.CONCLUSION: The findings reinforce that the complex drug therapy prescriptions, little knowledge about the disease and dissatisfaction with the healthcare service have influence on the process of non-adherence to anti-hypertensive drug therapy.

scholarly journals Understanding epigenetics of schizophrenia in the backdrop of its antipsychotic drug therapy

Epigenomics ◽  
2017 ◽  
Vol 9 (5) ◽  
pp. 721-736 ◽  
Author(s):  
Babu Swathy ◽  
Moinak Banerjee
Keyword(s):  
Drug Therapy ◽  
Antipsychotic Drug

scholarly journals Factors associated with COVID-19 related hospitalisation, critical care admission and mortality using linked primary and secondary care data

2021 ◽  
Author(s):  
Lisa Cummins ◽  
Irene Ebyarimpa ◽  
Nathan Cheetham ◽  
Victoria Tzortziou Brown ◽  
Katie Brennan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Learning Disabilities ◽  
Secondary Care ◽  
Multivariate Logistic Regression Analysis ◽  
Additional Patient ◽  
Factors Associated ◽  
Icu Admission ◽  
Risk Of Death ◽  
North East ◽  
Increased Risk

AbstractBackgroundTo identify risk factors associated with increased risk of hospitalisation, intensive care unit (ICU) admission and mortality in inner North East London (NEL) during the first UK COVID-19 wave.MethodsMultivariate logistic regression analysis on linked primary and secondary care data from people aged 16 or older with confirmed COVID-19 infection between 01/02/2020-30/06/2020 determined odds ratios (OR), 95% confidence intervals (CI) and p-values for the association between demographic, deprivation and clinical factors with COVID-19 hospitalisation, ICU admission and mortality.ResultsOver the study period 1,781 people were diagnosed with COVID-19, of whom 1,195 (67%) were hospitalised, 152 (9%) admitted to ICU and 400 (23%) died. Results confirm previously identified risk factors: being male, or of Black or Asian ethnicity, or aged over 50. Obesity, type 2 diabetes and chronic kidney disease (CKD) increased the risk of hospitalisation. Obesity increased the risk of being admitted to ICU. Underlying CKD, stroke and dementia in-creased the risk of death. Having learning disabilities was strongly associated with increased risk of death (OR=4.75, 95%CI=(1.91,11.84), p=0.001). Having three or four co-morbidities increased the risk of hospitalisation (OR=2.34,95%CI=(1.55,3.54),p<0.001;OR=2.40, 95%CI=(1.55,3.73), p<0.001 respectively) and death (OR=2.61, 95%CI=(1.59,4.28), p<0.001;OR=4.07, 95% CI= (2.48,6.69), p<0.001 respectively).ConclusionsWe confirm that age, sex, ethnicity, obesity, CKD and diabetes are important determinants of risk of COVID-19 hospitalisation or death. For the first time, we also identify people with learning disabilities and multi-morbidity as additional patient cohorts that need to be actively protected during COVID-19 waves.

The Scottish First Episode Schizophrenia Study

1992 ◽  
Vol 161 (4) ◽  
pp. 496-500 ◽  
Author(s):  
Robin G. McCreadie ◽  
David H. Wiles ◽  
Martin G. Livingston ◽  
James A. G. Watt ◽  
J. G. Greene ◽  
...  
Keyword(s):  
Psychological Distress ◽  
Drug Therapy ◽  
Psychological Stress ◽  
Antipsychotic Drug ◽  
First Episode ◽  
Poor Outcome ◽  
Schizophrenic Patients ◽  
First Episode Schizophrenia ◽  
First Admission

Forty-four schizophrenic patients were followed up for five years after their first admission to hospital for a first episode of illness. Thirteen (30%) of 43 patients had not relapsed; 28 of the 30 patients who did relapse did so within the first 42 months. The relapses occurred despite antipsychotic drug therapy. Also, 24% of patients had at least one course of ECT. Only 19% of the patients at five years were in open employment; unemployment was strongly associated with relapse. Eighteen per cent had neither relapses nor schizophrenic symptoms at follow-up. Poor outcome at five years was associated with greater psychological distress among relatives at first admission. At five years 43% of relatives continued to show case level psychological stress.

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