scholarly journals Knowledge about hypertension and factors associated with the non-adherence to drug therapy

2014 ◽  
Vol 22 (3) ◽  
pp. 491-498 ◽  
Author(s):  
Mayckel da Silva Barreto ◽  
Annelita Almeida Oliveira Reiners ◽  
Sonia Silva Marcon
Keyword(s):  
Drug Therapy ◽  
Healthcare Service ◽  
Cross Sectional Study ◽  
Medication Regimen ◽  
Cross Sectional ◽  
Poor Knowledge ◽  
Factors Associated ◽  
Medication Regimen Complexity ◽  
Hypertensive Drug ◽  
Complex Drug

OBJECTIVES: to identify the degree of knowledge of people with hypertension concerning the disease and to verify the factors associated with the non-adherence to anti-hypertensive drug therapy.METHOD: Cross sectional study, involving 422 people. Data collection took place at their homes, between December 2011 and March 2012, through interviews using the following instruments: Medication Adherence Questionnaire (MAQ-Q), Medication Regimen Complexity Index (MRCI) and a guide with questions related to sociodemographic profile, satisfaction with healthcare service and knowledge about the disease.RESULTS: 42.6% did not adhere to the drug therapy and 17.7% had poor knowledge about the disease. Factors associated with the non-adherence were: complex drug therapy, poor knowledge about the disease and dissatisfaction with the healthcare service.CONCLUSION: The findings reinforce that the complex drug therapy prescriptions, little knowledge about the disease and dissatisfaction with the healthcare service have influence on the process of non-adherence to anti-hypertensive drug therapy.

Factors associated with medication regimen complexity in older people: a cross-sectional population-based study

2015 ◽  
Vol 71 (9) ◽  
pp. 1099-1108 ◽  
Author(s):  
Barbara Caecilia Wimmer ◽  
Kristina Johnell ◽  
Johan Fastbom ◽  
Michael David Wiese ◽  
J. Simon Bell
Keyword(s):  
Older People ◽  
Population Based ◽  
Medication Regimen ◽  
Cross Sectional ◽  
Population Based Study ◽  
Factors Associated ◽  
Medication Regimen Complexity ◽  
Regimen Complexity

scholarly journals Risk factors associated with drug therapy among elderly people with Alzheimer’s disease: a cross-sectional study

2020 ◽  
Vol 138 (3) ◽  
pp. 216-218
Author(s):  
Marcela Forgerini ◽  
Maria Teresa Herdeiro ◽  
José Carlos Fernandes Galduróz ◽  
Patrícia de Carvalho Mastroianni
Keyword(s):  
Risk Factors ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Drug Therapy ◽  
Elderly People ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Factors Associated

scholarly journals Respiratory-tract infections among geriatrics: prevalence and factors associated with the treatment outcomes

2021 ◽  
Vol 15 ◽  
pp. 175346662097114
Author(s):  
Ali Akhtar ◽  
Mohamed Azmi Ahmad Hassali ◽  
Hadzliana Zainal ◽  
Irfhan Ali ◽  
Muhammad Shahid Iqbal ◽  
...  
Keyword(s):  
Respiratory Tract ◽  
Treatment Outcomes ◽  
Respiratory Tract Infections ◽  
Community Acquired Pneumonia ◽  
Chronic Obstructive ◽  
Medication Regimen ◽  
Cross Sectional ◽  
Factors Associated ◽  
Medication Regimen Complexity ◽  
Tract Infections

Background: Geriatric individuals are more susceptible to different infections, especially respiratory-tract infections (RTIs) due to their compromised immune system. Hence, the objectives of the present study were to evaluate the prevalence, medication regimen complexity and factors associated with the treatment outcomes of different RTIs among geriatrics. Methods: A retrospective cross-sectional study (5 years) was conducted at the respiratory department, Hospital Pulau Pinang. Patients aged ⩾65 years with confirmed diagnosis of RTI were included in the study. Results: A total of 474 patients were included, and the most prevalent RTIs were community-acquired pneumonia (65.6%) followed by chronic obstructive pulmonary disease (20.7%), bronchitis (8.2%) and hospital-acquired pneumonia (5.5%). Amoxicillin/clavulanate (69.8%), ampicillin/sulbactam (9.1%) and cefuroxime (6.5%) are the most common antibiotics prescribed to treat RTIs among geriatrics. Smoking, alcohol consumption, polypharmacy and presence of other co-morbidities are statistically significant factors associated with treatment outcomes of RTIs among geriatrics. Conclusion: Prevalence of community-acquired pneumonia (65.6%) among older patients aged 65 years and older higher than other RTIs. Smoking, alcohol use, presence of polypharmacy and other co-morbidities are important factors associated with the treatment outcomes of RTIs. The reviews of this paper are available via the supplemental material section.

scholarly journals A Cross-Sectional Assessment of Urinary Tract Infections Among Geriatric Patients: Prevalence, Medication Regimen Complexity, and Factors Associated With Treatment Outcomes

2021 ◽  
Vol 9 ◽  
Author(s):  
Ali Akhtar ◽  
Mohamed Azmi Ahmad Hassali ◽  
Hadzliana Zainal ◽  
Irfhan Ali ◽  
Amer Hayat Khan
Keyword(s):  
Older Adults ◽  
Urinary Tract ◽  
Treatment Outcomes ◽  
Medication Regimen ◽  
Cross Sectional ◽  
Factors Associated ◽  
Medication Regimen Complexity ◽  
Regimen Complexity ◽  
Study Population ◽  
Tract Infections

Background: Urinary tract infections (UTIs) are the second most prevalent infection among the elderly population. Hence, the current study aimed to evaluate the prevalence of UTIs among older adults, medication regimen complexity, and the factors associated with the treatment outcomes of elderly patients infected with UTIs.Methods: A retrospective cross-sectional study was conducted at the Department of Urology, Hospital Pulau Pinang, Malaysia. The patients ≥65 years of age were included in the present study with a confirmed diagnosis of UTIs from 2014 to 2018 (5 years).Results: A total of 460 patients met the inclusion criteria and were included in the present study. Cystitis (37.6%) was the most prevalent UTI among the study population followed by asymptomatic bacteriuria (ASB) (31.9%), pyelonephritis (13.9%), urosepsis (10.2%), and prostatitis (6.4%). Unasyn (ampicillin and sulbactam) was used to treat the UTIs followed by Bactrim (trimethoprim/sulfamethoxazole), and ciprofloxacin. The factors associated with the treatment outcomes of UTIs were gender (odd ratio [OR] = 1.628; p = 0.018), polypharmacy (OR = 0.647; p = 0.033), and presence of other comorbidities (OR = 2.004; p = 0.002) among the study population.Conclusion: Cystitis is the most common UTI observed in older adults. Gender, the burden of polypharmacy, and the presence of comorbidities are the factors that directly affect the treatment outcomes of UTIs among the study population.

scholarly journals Complexity of pharmacotherapeutic regimens for older adults in primary care in Brazil: a cross-sectional study

2021 ◽  
Author(s):  
Mariana Carvalho Bilac ◽  
Luiz Santana Passos ◽  
Romana Santos Gama ◽  
Renato Morais Souza ◽  
Welma Wildes Amorim ◽  
...  
Keyword(s):  
Primary Care ◽  
Older People ◽  
Care Setting ◽  
Primary Care Setting ◽  
Cross Sectional Study ◽  
Medication Regimen ◽  
Cross Sectional ◽  
Medication Regimen Complexity ◽  
Complexity Index ◽  
Regimen Complexity

Aims: Adherence to prescribed treatment is important for obtaining the desired outcomes in older people care. Polypharmacy is strictly associated with adherence, and complex pharmacotherapy can lead to poor adherence and unexpected outcomes, which are aggravated by older age. The medication regimen complexity index has been proven to be a valid and reliable tool for quantifying the complexity of medication regimens. The objective of the present study was to evaluate the therapeutic complexity of drugs used by older people in a primary care setting in Brazil. Methods: This was a cross-sectional study conducted in 22 basic health units in Brazil. Older people from this sample who were treated in a primary care setting were interviewed after a consultation with a family practice physician. Data were collected from September 2016 to March 2019. Patients aged ≥ 60 years who visited the primary care units were included in the study. Pharmacotherapeutic complexity was assessed according to the medication regimen complexity index. Results: In all, 675 individuals with a mean age of 70 years (±7.1 years) were included. The mean number of drugs prescribed per capita was 2.9 (±1.8). The median medication regimen complexity index for the sample was 8.0, and 26.1% of the patients interviewed had a high medication regimen complexity index. Conclusion: The complexity of the drug regimen was high in almost one-third of the prescriptions analysed. This high complexity might contribute to non-adherence to medication regimens, leading to safety- and effectiveness-related issues. Key words: drug prescriptions, geriatrics, pharmaceutical preparations, polypharmacy, primary health care, older patient.

scholarly journals Drug therapy and other factors associated with the development of acute kidney injury in critically ill patients: a cross-sectional study

PeerJ ◽  
2018 ◽  
Vol 6 ◽  
pp. e5405
Author(s):  
Danielly Botelho Soares ◽  
Juliana Vaz de Melo Mambrini ◽  
Gabriela Rebouças Botelho ◽  
Flávia Fialho Girundi ◽  
Fernando Antonio Botoni ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Logistic Regression ◽  
Intensive Care ◽  
Drug Therapy ◽  
Kidney Injury ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Factors Associated ◽  
Nephrotoxic Drugs

Background Acute kidney injury (AKI) is associated with a significant increase in morbidity, mortality, and health care costs. In intensive care units (ICU), AKI is commonly multifactorial and frequently involves diverse factors, such as hypovolemia, sepsis, and the use of nephrotoxic drugs. We aimed to investigate drug therapy and other factors associated with the development of AKI in a Brazilian public hospital. Methods This is a cross-sectional study involving critically ill patients at an ICU of a tertiary hospital. All data on sequential serum creatinine (SCr) level, glomerular filtration rate (GFR), and urine output were collected during ICU stay. The primary outcome was the occurrence of AKI assessed by the Acute Kidney Injury Network (AKIN) criterion. Sociodemographics, clinical data and drug therapy were considered as covariates. Factors associated with AKI were assessed using logistic regression. Results Overall, 122 participants were included in the study. Median age was 46.0 (interquartile range, IQ = 29.0–69.0) years, with a predominance of men (58.2%). Mean number of prescribed drugs throughout ICU stay was 22.0 ± 9.4. The number of potentially nephrotoxic drugs ranged from two to 24 per patient. A total of 29 (23.8%) ICU patients developed AKI. In the AKI-group, patients were older and showed higher Acute Physiology and Chronic Health Evaluation II (APACHE II) scores at admission, higher rates of sedation, mechanical ventilation, and infection. More drugs in general and specifically more vasoactive drugs were prescribed for AKI group. Patients who developed AKI tended to have extended stays in the ICU and a lower probability of being discharged alive than patients with no AKI development. Model adjustments of logistic regression showed that the number of medications (OR 1.15; 95% CI [1.05–1.27]) was the only factor associated with AKI in this study. This association was independent of drug nephrotoxicity. Discussion Intensive care is characterized by its complexity that combines unstable patients, severe diseases, high density of medical interventions, and drug use. We found that typical risk factors for AKI showed statistical association on bivariate analysis. The contribution of drug therapy in the occurrence of AKI in medical ICUs reinforces the need for prevention strategies focused on early recognition of renal dysfunction and interventions in drug therapy. These actions would help improve the quality of patient care and ensure progress towards medication safety.

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