Calcium-binding protein secretagogin-expressing neurones in the human hippocampus are largely resistant to neurodegeneration in Alzheimer's disease

2007 ◽  
Vol 0 (0) ◽  
pp. 071026235340001-??? ◽  
Author(s):  
J. Attems ◽  
M. Preusser ◽  
M. Grosinger-Quass ◽  
L. Wagner ◽  
F. Lintner ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Calcium Binding ◽  
Binding Protein ◽  
Calcium Binding Protein ◽  
Human Hippocampus

scholarly journals A Myristoylated Calcium-binding Protein that Preferentially Interacts with the Alzheimer's Disease Presenilin 2 Protein

1999 ◽  
Vol 145 (6) ◽  
pp. 1277-1292 ◽  
Author(s):  
Stacy M. Stabler ◽  
Lisa L. Ostrowski ◽  
Susan M. Janicki ◽  
Mervyn J. Monteiro
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cell Death ◽  
Hela Cells ◽  
Calcium Binding ◽  
Binding Protein ◽  
Calcium Binding Protein ◽  
Cellular Functions ◽  
Disease States ◽  
Presenilin 2

It is well established that mutations in the presenilin 1 and 2 genes cause the majority of early onset Alzheimer's disease (AD). However, our understanding of the cellular functions of the proteins they encode remains rudimentary. Knowledge of proteins with which the presenilins interact should lead to a better understanding of presenilin function in normal and disease states. We report here the identification of a calcium-binding protein, calmyrin, that interacts preferentially with presenilin 2 (PS2). Calmyrin is myristoylated, membrane-associated, and colocalizes with PS2 when the two proteins are overexpressed in HeLa cells. Yeast two-hybrid liquid assays, affinity chromatography, and coimmunoprecipitation experiments confirm binding between PS2 and calmyrin. Functionally, calmyrin and PS2 increase cell death when cotransfected into HeLa cells. These results allude to several provocative possibilities for a dynamic role of calmyrin in signaling, cell death, and AD.

scholarly journals Alterations of neurocalcin, a calcium-binding protein, in Alzheimer’s disease.

1996 ◽  
Vol 71 ◽  
pp. 282
Author(s):  
Motohiko Chachin ◽  
Takashi Taniguchi ◽  
Hiroyoshi Hidaka ◽  
Shun Shimohama
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Calcium Binding ◽  
Binding Protein ◽  
Calcium Binding Protein

Immunoreactivity of calcium binding protein secretagogin in the human hippocampus is restricted to pyramidal neurons

2007 ◽  
Vol 42 (3) ◽  
pp. 215-222 ◽  
Author(s):  
J ATTEMS ◽  
M QUASS ◽  
W GARTNER ◽  
A NABOKIKH ◽  
L WAGNER ◽  
...  
Keyword(s):  
Calcium Binding ◽  
Pyramidal Neurons ◽  
Binding Protein ◽  
Calcium Binding Protein ◽  
Human Hippocampus

Calcium-binding protein (calbindin-D28K) and parvalbumin immunocytochemistry in the normal and epileptic human hippocampus

1991 ◽  
Vol 308 (3) ◽  
pp. 381-396 ◽  
Author(s):  
Robert S. Sloviter ◽  
Anne L. Sollas ◽  
Nicholas M. Barbaro ◽  
Kenneth D. Laxer
Keyword(s):  
Calcium Binding ◽  
Binding Protein ◽  
Calcium Binding Protein ◽  
Human Hippocampus ◽  
Calbindin D28k

P3-183: Cellular immunoreactivity of calcium-binding protein secretagogin in human hippocampus is restricted to pyramidal neurons

2006 ◽  
Vol 2 ◽  
pp. S428-S428
Author(s):  
Johannes Attems ◽  
Magdalena Quass ◽  
Wolfgang Gartner ◽  
Ludwig Wagner ◽  
Kurt A. Jellinger ◽  
...  
Keyword(s):  
Calcium Binding ◽  
Pyramidal Neurons ◽  
Binding Protein ◽  
Calcium Binding Protein ◽  
Human Hippocampus
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